Prognostic Value of Perineural Invasion in Patients with Stage II Colorectal Cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-08

AUTHORS

Jung Wook Huh, Hyeong Rok Kim, Young Jin Kim

ABSTRACT

BACKGROUND: Perineural invasion (PNI) may influence the prognosis after resection of colorectal cancer (CRC); whether this is a definite prognostic factor remains controversial. This study determined the clinicopathologic factors associated with oncologic outcome after radical resection of stage II CRC, focusing on PNI. MATERIALS AND METHODS: We retrospectively reviewed 341 consecutive patients who underwent curative surgery for stage II CRC between January 2001 and December 2006. Of these, 278 patients (81.5%) received postoperative 5-fluorouracil-based chemotherapy. The oncologic outcomes and the risk factors for recurrence were analyzed. RESULTS: PNI was detected in 57 of 341 patients (16.7%) and was significantly associated with depth of tumor invasion (P = .035) and positive lymphovascular invasion (P < .001). Multivariate analyses revealed that PNI was a significant independent prognostic factor for disease-free survival, not for overall survival. With a median follow-up period of 57.6 months, the 5-year disease-free and overall survival rates of the patients were 80.2 and 82.6%, respectively. The 5-year disease-free survival of the PNI-negative group was significantly higher than that of the PNI-positive group (P < .001). Within the PNI-positive patients, those receiving chemotherapy had significantly higher 5-year disease-free survival than the others (P = .023). CONCLUSION: This study illustrates the value of PNI as a prognostic factor for stage II CRC. Moreover, PNI-positive patients should be considered for postoperative chemotherapy. More... »

PAGES

2066-2072

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-010-0982-7

DOI

http://dx.doi.org/10.1245/s10434-010-0982-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046882569

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20182809


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Nerves", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huh", 
        "givenName": "Jung Wook", 
        "id": "sg:person.01310235260.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyeong Rok", 
        "id": "sg:person.0726026302.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726026302.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Jin", 
        "id": "sg:person.01042531610.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042531610.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10350-007-9072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000004696", 
          "https://doi.org/10.1007/s10350-007-9072-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-007-9072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000004696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-007-9072-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000004696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.04.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000536361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-007-9024-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002743865", 
          "https://doi.org/10.1007/s10350-007-9024-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-007-9024-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002743865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s005200050080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008309252", 
          "https://doi.org/10.1007/s005200050080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02234390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012493434", 
          "https://doi.org/10.1007/bf02234390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012493434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02234390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012493434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1827.2009.02357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013153041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1827.2009.02357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013153041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0752-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013524235", 
          "https://doi.org/10.1007/s00428-009-0752-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0752-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013524235", 
          "https://doi.org/10.1007/s00428-009-0752-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-009-0752-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013524235", 
          "https://doi.org/10.1007/s00428-009-0752-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000077348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015196599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.20942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018981922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djh275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019244817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-004-6423-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020204794", 
          "https://doi.org/10.1007/s10350-004-6423-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-004-6423-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020204794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-004-6423-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020204794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0424-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021285289", 
          "https://doi.org/10.1245/s10434-009-0424-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-009-0424-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021285289", 
          "https://doi.org/10.1245/s10434-009-0424-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10350-008-9246-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023365584", 
          "https://doi.org/10.1007/s10350-008-9246-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/s10350-008-9246-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023365584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025416621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032122246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.21495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032122246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02050424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035474813", 
          "https://doi.org/10.1007/bf02050424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02050424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035474813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02050424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035474813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038295854", 
          "https://doi.org/10.1038/sj.bjc.6690033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038295854", 
          "https://doi.org/10.1038/sj.bjc.6690033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200204000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044540186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200204000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044540186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjsurg.2008.09.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044902972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02237122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045311532", 
          "https://doi.org/10.1007/bf02237122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02237122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045311532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02237122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045311532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.05.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047793732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<274::aid-cncr5>3.0.co;2-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049587882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950815)76:4<564::aid-cncr2820760405>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050678700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010915)92:6<1435::aid-cncr1467>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050867221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200104193441603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051987393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.09.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052883048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.0007-1323.2001.01810.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053554461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.5.1349", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074460851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2005.0024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077087189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2005.0024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077087189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.22.14_suppl.4142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084614152"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-08", 
    "datePublishedReg": "2010-08-01", 
    "description": "BACKGROUND: Perineural invasion (PNI) may influence the prognosis after resection of colorectal cancer (CRC); whether this is a definite prognostic factor remains controversial. This study determined the clinicopathologic factors associated with oncologic outcome after radical resection of stage II CRC, focusing on PNI.\nMATERIALS AND METHODS: We retrospectively reviewed 341 consecutive patients who underwent curative surgery for stage II CRC between January 2001 and December 2006. Of these, 278 patients (81.5%) received postoperative 5-fluorouracil-based chemotherapy. The oncologic outcomes and the risk factors for recurrence were analyzed.\nRESULTS: PNI was detected in 57 of 341 patients (16.7%) and was significantly associated with depth of tumor invasion (P = .035) and positive lymphovascular invasion (P < .001). Multivariate analyses revealed that PNI was a significant independent prognostic factor for disease-free survival, not for overall survival. With a median follow-up period of 57.6 months, the 5-year disease-free and overall survival rates of the patients were 80.2 and 82.6%, respectively. The 5-year disease-free survival of the PNI-negative group was significantly higher than that of the PNI-positive group (P < .001). Within the PNI-positive patients, those receiving chemotherapy had significantly higher 5-year disease-free survival than the others (P = .023).\nCONCLUSION: This study illustrates the value of PNI as a prognostic factor for stage II CRC. Moreover, PNI-positive patients should be considered for postoperative chemotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1245/s10434-010-0982-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105545", 
        "issn": [
          "1068-9265", 
          "1534-4681"
        ], 
        "name": "Annals of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Prognostic Value of Perineural Invasion in Patients with Stage II Colorectal Cancer", 
    "pagination": "2066-2072", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "df54cebd88b108925fe60f0d3521e34d1996edce2b2184e719e0e3305651f18e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20182809"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9420840"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1245/s10434-010-0982-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046882569"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1245/s10434-010-0982-7", 
      "https://app.dimensions.ai/details/publication/pub.1046882569"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89822_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1245/s10434-010-0982-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-0982-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-0982-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-0982-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-010-0982-7'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      90 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-010-0982-7 schema:about N05f805c4ce57495084a430d3d2fadb7a
2 N1a49332f314a49fe9e90efb63f00edd7
3 N1aa71298c28b43d5983c05f689e69590
4 N205fb0baa26d48a09a9562c406882b0b
5 N31c3df49524f46f1900fd6f25a4038c8
6 N33830714f7434160b80dd3544118f434
7 N344ade1dbb5b4e2698210a739bc046b0
8 N41ac278ae8d341f1ba09c2c8ccd27a5e
9 N5c3cf52d782949ea989d650fdd208959
10 N643d3a5ae57245ebb0e2c0045b097731
11 N6b0209587c8b40639fe9667c7be6e42e
12 N84f49b031b1e4184a6796216e0fb91d4
13 N88a19b67b40e4d07aa0b7e5e1f1c6b4e
14 N8c57d2b48b954d4e8c2dc7855b2a608b
15 Na70cac3a081c4c9888fcf4fe080f3a7e
16 Na821de079c92414c92a97814b889d3b7
17 Naedae699f5ea42c39ad466ecff616f66
18 Nbdd0b482b8a2444eb7408c49ab1464ec
19 Nc9b5d6c5daa84563b05b1440320b437a
20 Nc9c4e21dd9ee4223b2399a9df6064a2e
21 Ndae65a4387ff47fdb27dd938c38bae18
22 Ndd0df52d80d8492cac685240cce6f86f
23 Nff2f15da36fb44b1806d13ab821d7227
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author Na8223da4b488427287cd61509187fe28
27 schema:citation sg:pub.10.1007/bf02050424
28 sg:pub.10.1007/bf02234390
29 sg:pub.10.1007/bf02237122
30 sg:pub.10.1007/s00428-009-0752-8
31 sg:pub.10.1007/s005200050080
32 sg:pub.10.1007/s10350-004-6423-6
33 sg:pub.10.1007/s10350-007-9024-3
34 sg:pub.10.1007/s10350-007-9072-8
35 sg:pub.10.1007/s10350-008-9246-z
36 sg:pub.10.1038/sj.bjc.6690033
37 sg:pub.10.1245/s10434-009-0424-6
38 https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<274::aid-cncr5>3.0.co;2-r
39 https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i
40 https://doi.org/10.1002/1097-0142(19950815)76:4<564::aid-cncr2820760405>3.0.co;2-z
41 https://doi.org/10.1002/1097-0142(20010915)92:6<1435::aid-cncr1467>3.0.co;2-n
42 https://doi.org/10.1002/jso.20942
43 https://doi.org/10.1002/jso.21495
44 https://doi.org/10.1007/bf02050424
45 https://doi.org/10.1007/bf02234390
46 https://doi.org/10.1007/bf02237122
47 https://doi.org/10.1007/s10350-004-6423-6
48 https://doi.org/10.1007/s10350-007-9024-3
49 https://doi.org/10.1007/s10350-007-9072-8
50 https://doi.org/10.1007/s10350-008-9246-z
51 https://doi.org/10.1016/j.amjsurg.2008.09.027
52 https://doi.org/10.1046/j.0007-1323.2001.01810.x
53 https://doi.org/10.1056/nejm200104193441603
54 https://doi.org/10.1093/jnci/djh275
55 https://doi.org/10.1097/00000658-200204000-00002
56 https://doi.org/10.1111/j.1440-1827.2009.02357.x
57 https://doi.org/10.1159/000077348
58 https://doi.org/10.1200/jco.1999.17.5.1349
59 https://doi.org/10.1200/jco.2003.05.044
60 https://doi.org/10.1200/jco.2004.04.065
61 https://doi.org/10.1200/jco.2004.05.063
62 https://doi.org/10.1200/jco.2004.09.059
63 https://doi.org/10.1200/jco.2004.22.14_suppl.4142
64 https://doi.org/10.6004/jnccn.2005.0024
65 schema:datePublished 2010-08
66 schema:datePublishedReg 2010-08-01
67 schema:description BACKGROUND: Perineural invasion (PNI) may influence the prognosis after resection of colorectal cancer (CRC); whether this is a definite prognostic factor remains controversial. This study determined the clinicopathologic factors associated with oncologic outcome after radical resection of stage II CRC, focusing on PNI. MATERIALS AND METHODS: We retrospectively reviewed 341 consecutive patients who underwent curative surgery for stage II CRC between January 2001 and December 2006. Of these, 278 patients (81.5%) received postoperative 5-fluorouracil-based chemotherapy. The oncologic outcomes and the risk factors for recurrence were analyzed. RESULTS: PNI was detected in 57 of 341 patients (16.7%) and was significantly associated with depth of tumor invasion (P = .035) and positive lymphovascular invasion (P < .001). Multivariate analyses revealed that PNI was a significant independent prognostic factor for disease-free survival, not for overall survival. With a median follow-up period of 57.6 months, the 5-year disease-free and overall survival rates of the patients were 80.2 and 82.6%, respectively. The 5-year disease-free survival of the PNI-negative group was significantly higher than that of the PNI-positive group (P < .001). Within the PNI-positive patients, those receiving chemotherapy had significantly higher 5-year disease-free survival than the others (P = .023). CONCLUSION: This study illustrates the value of PNI as a prognostic factor for stage II CRC. Moreover, PNI-positive patients should be considered for postoperative chemotherapy.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf Na94bc958510d4d9e8d2a980d1ece7f76
72 Ne0d6ba84cf9449d5be778384b9037cd3
73 sg:journal.1105545
74 schema:name Prognostic Value of Perineural Invasion in Patients with Stage II Colorectal Cancer
75 schema:pagination 2066-2072
76 schema:productId N3929bb4e3f6543d2ad71376364c00c71
77 N5172dee65fbe45c28c0162fb039e2203
78 N65793ca561654b1ea9d8fd7cbc81ba84
79 N6bb4e6b7b8d34a219beb1a9cdb45b827
80 N9be69ddccc534cf6b574b9d261864791
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046882569
82 https://doi.org/10.1245/s10434-010-0982-7
83 schema:sdDatePublished 2019-04-11T10:02
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher Nd0f3c762277742a5b9a292316136f9a4
86 schema:url http://link.springer.com/10.1245/s10434-010-0982-7
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N05f805c4ce57495084a430d3d2fadb7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Peripheral Nerves
92 rdf:type schema:DefinedTerm
93 N1a49332f314a49fe9e90efb63f00edd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Follow-Up Studies
95 rdf:type schema:DefinedTerm
96 N1aa71298c28b43d5983c05f689e69590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Invasiveness
98 rdf:type schema:DefinedTerm
99 N205fb0baa26d48a09a9562c406882b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Risk Factors
101 rdf:type schema:DefinedTerm
102 N31c3df49524f46f1900fd6f25a4038c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Middle Aged
104 rdf:type schema:DefinedTerm
105 N33830714f7434160b80dd3544118f434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Multivariate Analysis
107 rdf:type schema:DefinedTerm
108 N344ade1dbb5b4e2698210a739bc046b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Retrospective Studies
110 rdf:type schema:DefinedTerm
111 N3929bb4e3f6543d2ad71376364c00c71 schema:name readcube_id
112 schema:value df54cebd88b108925fe60f0d3521e34d1996edce2b2184e719e0e3305651f18e
113 rdf:type schema:PropertyValue
114 N41ac278ae8d341f1ba09c2c8ccd27a5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Young Adult
116 rdf:type schema:DefinedTerm
117 N5172dee65fbe45c28c0162fb039e2203 schema:name dimensions_id
118 schema:value pub.1046882569
119 rdf:type schema:PropertyValue
120 N5c3cf52d782949ea989d650fdd208959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neoplasm Staging
122 rdf:type schema:DefinedTerm
123 N643d3a5ae57245ebb0e2c0045b097731 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 N65793ca561654b1ea9d8fd7cbc81ba84 schema:name doi
127 schema:value 10.1245/s10434-010-0982-7
128 rdf:type schema:PropertyValue
129 N6b0209587c8b40639fe9667c7be6e42e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Fluorouracil
131 rdf:type schema:DefinedTerm
132 N6bb4e6b7b8d34a219beb1a9cdb45b827 schema:name pubmed_id
133 schema:value 20182809
134 rdf:type schema:PropertyValue
135 N7410e0931055496d9feea4ca2caa29f3 rdf:first sg:person.01042531610.61
136 rdf:rest rdf:nil
137 N84f49b031b1e4184a6796216e0fb91d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Aged
139 rdf:type schema:DefinedTerm
140 N88a19b67b40e4d07aa0b7e5e1f1c6b4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Colorectal Neoplasms
142 rdf:type schema:DefinedTerm
143 N8c57d2b48b954d4e8c2dc7855b2a608b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Neoplasm Recurrence, Local
145 rdf:type schema:DefinedTerm
146 N9be69ddccc534cf6b574b9d261864791 schema:name nlm_unique_id
147 schema:value 9420840
148 rdf:type schema:PropertyValue
149 Na70cac3a081c4c9888fcf4fe080f3a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Survival Analysis
151 rdf:type schema:DefinedTerm
152 Na821de079c92414c92a97814b889d3b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Treatment Outcome
154 rdf:type schema:DefinedTerm
155 Na8223da4b488427287cd61509187fe28 rdf:first sg:person.01310235260.89
156 rdf:rest Ne791da6761bd46c6b5eea225d897ebf8
157 Na94bc958510d4d9e8d2a980d1ece7f76 schema:volumeNumber 17
158 rdf:type schema:PublicationVolume
159 Nae223df2ef584e7eb0619829df8518ac schema:name Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea
160 rdf:type schema:Organization
161 Naedae699f5ea42c39ad466ecff616f66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Chemotherapy, Adjuvant
163 rdf:type schema:DefinedTerm
164 Nbdd0b482b8a2444eb7408c49ab1464ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Prognosis
166 rdf:type schema:DefinedTerm
167 Nc7b411360e594f6295f760087204bab5 schema:name Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea
168 rdf:type schema:Organization
169 Nc9b5d6c5daa84563b05b1440320b437a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Humans
171 rdf:type schema:DefinedTerm
172 Nc9c4e21dd9ee4223b2399a9df6064a2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Aged, 80 and over
174 rdf:type schema:DefinedTerm
175 Nd0f3c762277742a5b9a292316136f9a4 schema:name Springer Nature - SN SciGraph project
176 rdf:type schema:Organization
177 Nd477abf1907e4cee8b812b787c7e11d1 schema:name Department of Surgery, Chonnam National University Hwasun Hospital and Medical School, Gwangju, Korea
178 rdf:type schema:Organization
179 Ndae65a4387ff47fdb27dd938c38bae18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Female
181 rdf:type schema:DefinedTerm
182 Ndd0df52d80d8492cac685240cce6f86f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Adult
184 rdf:type schema:DefinedTerm
185 Ne0d6ba84cf9449d5be778384b9037cd3 schema:issueNumber 8
186 rdf:type schema:PublicationIssue
187 Ne791da6761bd46c6b5eea225d897ebf8 rdf:first sg:person.0726026302.07
188 rdf:rest N7410e0931055496d9feea4ca2caa29f3
189 Nff2f15da36fb44b1806d13ab821d7227 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Antineoplastic Agents
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
196 schema:name Oncology and Carcinogenesis
197 rdf:type schema:DefinedTerm
198 sg:journal.1105545 schema:issn 1068-9265
199 1534-4681
200 schema:name Annals of Surgical Oncology
201 rdf:type schema:Periodical
202 sg:person.01042531610.61 schema:affiliation Nd477abf1907e4cee8b812b787c7e11d1
203 schema:familyName Kim
204 schema:givenName Young Jin
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042531610.61
206 rdf:type schema:Person
207 sg:person.01310235260.89 schema:affiliation Nae223df2ef584e7eb0619829df8518ac
208 schema:familyName Huh
209 schema:givenName Jung Wook
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310235260.89
211 rdf:type schema:Person
212 sg:person.0726026302.07 schema:affiliation Nc7b411360e594f6295f760087204bab5
213 schema:familyName Kim
214 schema:givenName Hyeong Rok
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726026302.07
216 rdf:type schema:Person
217 sg:pub.10.1007/bf02050424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035474813
218 https://doi.org/10.1007/bf02050424
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf02234390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012493434
221 https://doi.org/10.1007/bf02234390
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/bf02237122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045311532
224 https://doi.org/10.1007/bf02237122
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s00428-009-0752-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013524235
227 https://doi.org/10.1007/s00428-009-0752-8
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/s005200050080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008309252
230 https://doi.org/10.1007/s005200050080
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/s10350-004-6423-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020204794
233 https://doi.org/10.1007/s10350-004-6423-6
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/s10350-007-9024-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002743865
236 https://doi.org/10.1007/s10350-007-9024-3
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s10350-007-9072-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000004696
239 https://doi.org/10.1007/s10350-007-9072-8
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/s10350-008-9246-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023365584
242 https://doi.org/10.1007/s10350-008-9246-z
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/sj.bjc.6690033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038295854
245 https://doi.org/10.1038/sj.bjc.6690033
246 rdf:type schema:CreativeWork
247 sg:pub.10.1245/s10434-009-0424-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021285289
248 https://doi.org/10.1245/s10434-009-0424-6
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/(sici)1097-0142(19980115)82:2<274::aid-cncr5>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1049587882
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/(sici)1097-0142(19980815)83:4<666::aid-cncr6>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1025416621
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/1097-0142(19950815)76:4<564::aid-cncr2820760405>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1050678700
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/1097-0142(20010915)92:6<1435::aid-cncr1467>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1050867221
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/jso.20942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018981922
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/jso.21495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032122246
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1007/bf02050424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035474813
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1007/bf02234390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012493434
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1007/bf02237122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045311532
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1007/s10350-004-6423-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020204794
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1007/s10350-007-9024-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002743865
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1007/s10350-007-9072-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000004696
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1007/s10350-008-9246-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1023365584
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.amjsurg.2008.09.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044902972
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1046/j.0007-1323.2001.01810.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053554461
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1056/nejm200104193441603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051987393
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1093/jnci/djh275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019244817
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1097/00000658-200204000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044540186
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1111/j.1440-1827.2009.02357.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013153041
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1159/000077348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015196599
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1200/jco.1999.17.5.1349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074460851
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.2003.05.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203585
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2004.04.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000536361
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1200/jco.2004.05.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047793732
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1200/jco.2004.09.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052883048
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1200/jco.2004.22.14_suppl.4142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084614152
301 rdf:type schema:CreativeWork
302 https://doi.org/10.6004/jnccn.2005.0024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077087189
303 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...