Chordoma of the Mobile Spine and Sacrum: A Retrospective Analysis of a Series of Patients Surgically Treated at Two Referral ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10-22

AUTHORS

Silvia Stacchiotti, Paolo Giovanni Casali, Salvatore Lo Vullo, Luigi Mariani, Elena Palassini, Mario Mercuri, Marco Alberghini, Silvana Pilotti, Licciana Zanella, Alessandro Gronchi, Piero Picci

ABSTRACT

BackgroundChordoma is a rare tumor, and its natural history is still not well known.Materials and MethodsAll patients affected by localized chordoma surgically treated at Istituto Ortopedico Rizzoli, Bologna, and Istituto Nazionale Tumori, Milan, Italy, between 1980 and 2008 were reviewed. Local recurrence, distant metastasis, and overall survival (OS) were analyzed both from time of diagnosis and from time of local recurrence/distant metastasis. A multivariable analysis to identify independent prognostic factors was carried out.ResultsA total of 138 consecutive patients were identified (sacrum 78%, lumbar spine 15%, cervical-dorsal spine 7%). Of these, 130 underwent surgical resection. Median follow-up was 142 months. The 5- and 10-year OS, local relapse-free survival (LRFS), and distant relapse-free survival (DRFS) were, respectively, 78% and 54%, 52% and 33%, and 86% and 72%. Size was an independent prognostic factor for OS (P value < .001), LRFS (P value: .038), and DRFS (P value: .004), while surgical margins independently predicted LRFS (P value: .003) with a trend for OS. The 5- and 10-year OS, LRFS, and DRFS after the first local relapse were 50% and 26%, 47% and 31%, and 64% and 61%. The size of the recurrence and quality of surgical margins did not influence postrelapse OS. The 5-year OS after the second local relapse was 19%. 22% of patients developed distant metastases with a 5-year post-metastases OS of 33%.ConclusionsTumor size and surgical margins affected outcome only on initial presentation. However, wide surgery was feasible in a minority of cases. Most patients died of local–regional disease even when metastases occurred. Indeed, long-term prognosis was such that disease-free survival at 10 years was only 26%. More... »

PAGES

211-219

References to SciGraph publications

  • 2008-08. Metastatic disease from chordoma in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2003-04. Chordoma: Natural History and Results in 28 Patients Treated at a Single Institution in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-009-0740-x

    DOI

    http://dx.doi.org/10.1245/s10434-009-0740-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053702622

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19847568


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