Surgical Treatments and Prognoses of Patients with Combined Hepatocellular Carcinoma and Cholangiocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01-06

AUTHORS

Ki Hun Kim, Sung Gyu Lee, Eun Hwa Park, Shin Hwang, Chul Soo Ahn, Deok Bog Moon, Tae Yong Ha, Gi Won Song, Dong Hwan Jung, Kang Mo Kim, Young Suk Lim, Han Chu Lee, Young Hwa Chung, Yung Sang Lee, Dong Jin Suh

ABSTRACT

BackgroundCombined hepatocellular carcinoma and cholangiocarcinoma is a very rare form of primary liver cancer containing components of both tumor types. We evaluated the effectiveness of surgical treatment and factors related to survival and recurrence.Patients and MethodsOf the 2427 patients who underwent hepatectomy or liver transplantation because of a primary hepatic malignancy from January 1989 to July 2006 at the Asan Medical Center, Seoul, Korea, 29 had hepatocellular carcinoma and cholangiocarcinoma as a single mixed or transitional tumor. Their medical records were retrospectively reviewed.ResultsDisease-free survival rates at 6 months, 1 year, and 3 years were 51.1%, 38.3%, and 25.6%, respectively. Univariate analysis showed that CA 19–9 above 37 U/ml was predictive of low overall survival (P = .03) and that TNM stage was significantly associated with disease-free survival (P = .04).ConclusionsPatients with combined hepatocellular carcinoma and cholangiocarcinoma had poor postoperative survival rates. High CA 19–9 level was associated with poorer survival, suggesting that the cholangiocarcinoma portion may be a major determining factor for patient prognosis. Aggressive surgical treatment, including lymph node dissection, may improve survival in patients suspected of or diagnosed with these tumors. More... »

PAGES

623-629

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-008-0278-3

DOI

http://dx.doi.org/10.1245/s10434-008-0278-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030121265

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19130133


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33 schema:description BackgroundCombined hepatocellular carcinoma and cholangiocarcinoma is a very rare form of primary liver cancer containing components of both tumor types. We evaluated the effectiveness of surgical treatment and factors related to survival and recurrence.Patients and MethodsOf the 2427 patients who underwent hepatectomy or liver transplantation because of a primary hepatic malignancy from January 1989 to July 2006 at the Asan Medical Center, Seoul, Korea, 29 had hepatocellular carcinoma and cholangiocarcinoma as a single mixed or transitional tumor. Their medical records were retrospectively reviewed.ResultsDisease-free survival rates at 6 months, 1 year, and 3 years were 51.1%, 38.3%, and 25.6%, respectively. Univariate analysis showed that CA 19–9 above 37 U/ml was predictive of low overall survival (P = .03) and that TNM stage was significantly associated with disease-free survival (P = .04).ConclusionsPatients with combined hepatocellular carcinoma and cholangiocarcinoma had poor postoperative survival rates. High CA 19–9 level was associated with poorer survival, suggesting that the cholangiocarcinoma portion may be a major determining factor for patient prognosis. Aggressive surgical treatment, including lymph node dissection, may improve survival in patients suspected of or diagnosed with these tumors.
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40 schema:keywords Asan Medical Center
41 CA 19
42 Combined Hepatocellular Carcinoma
43 ConclusionsPatients
44 Korea
45 Medical Center
46 ResultsDisease-free survival rates
47 Seoul
48 TNM stage
49 aggressive surgical treatment
50 analysis
51 cancer
52 carcinoma
53 center
54 cholangiocarcinoma
55 cholangiocarcinoma portion
56 components
57 determining factors
58 disease-free survival
59 dissection
60 effectiveness
61 factors
62 form
63 hepatectomy
64 hepatic malignancies
65 hepatocellular carcinoma
66 high CA 19
67 levels
68 liver cancer
69 liver transplantation
70 lower overall survival
71 lymph node dissection
72 major determining factor
73 malignancy
74 medical records
75 methodsof
76 months
77 node dissection
78 overall survival
79 patient prognosis
80 patients
81 poor postoperative survival rates
82 poor survival
83 portion
84 postoperative survival rate
85 primary hepatic malignancy
86 primary liver cancer
87 prognosis
88 prognosis of patients
89 rare form
90 rate
91 records
92 recurrence
93 stage
94 surgical treatment
95 survival
96 survival rate
97 transitional tumors
98 transplantation
99 treatment
100 tumor types
101 tumors
102 types
103 univariate analysis
104 years
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