Ontology type: schema:ScholarlyArticle
2009-01-06
AUTHORSViniyendra Pamecha, Georgios Glantzounis, Niel Davies, Giuseppe Fusai, Dinesh Sharma, Brian Davidson
ABSTRACTBackgroundPortal vein embolisation (PVE) can be used to increase the remnant liver parenchyma volume before major hepatectomy but may stimulate tumour growth. The pattern of disease recurrence and long-term survival has not been adequately addressed.MethodsOver a period of 7 years 36 patients underwent preoperative PVE before resection of four or more liver segments for colorectal cancer (CRC) liver metastases. PVE was performed when the future liver remnant (FLR) assessed by magnetic resonance imaging (MRI) scan volumetry was less than 30%. Disease-free and overall survival was compared with a control group (65 patients) undergoing extended right/right hepatectomy for CRC metastases without PVE during the same time period.ResultsPVE was successful in all patients. PVE increased the median FLR volume by 37% [295 ml (22%) to 404 ml (32%), p < 0.0001]. 61% of patients undergoing PVE proceeded to liver resection (n = 22). Twelve patients (33%) developed disease progression following PVE. The 5-year survival after liver resection with PVE was 25%, compared with 50% without PVE. The 5-year disease-free survival was 30% post PVE and 50% without PVE.ConclusionWe conclude that PVE significantly increases the future liver remnant. Only two-thirds of patients proceed to resection because of disease progression. Long-term survival is less than in patients who do not require PVE. The effect of PVE on tumour growth requires investigation. More... »
PAGES1202
http://scigraph.springernature.com/pub.10.1245/s10434-008-0269-4
DOIhttp://dx.doi.org/10.1245/s10434-008-0269-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1000291548
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19130138
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Embolization, Therapeutic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hepatectomy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Regeneration",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Recurrence, Local",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Portal Vein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Preoperative Care",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Pamecha",
"givenName": "Viniyendra",
"id": "sg:person.0773502171.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773502171.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Glantzounis",
"givenName": "Georgios",
"id": "sg:person.01316266261.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316266261.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Radiology, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Department of Radiology, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Davies",
"givenName": "Niel",
"id": "sg:person.01110634532.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110634532.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Fusai",
"givenName": "Giuseppe",
"id": "sg:person.0604676213.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604676213.31"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Sharma",
"givenName": "Dinesh",
"id": "sg:person.01041615371.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041615371.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK",
"id": "http://www.grid.ac/institutes/grid.83440.3b",
"name": [
"Hepato-Pancreatico-Biliary and Liver Transplant Surgery, Royal Free Hospital and University College Medical School, University College London, NW3 2QG, London, UK"
],
"type": "Organization"
},
"familyName": "Davidson",
"givenName": "Brian",
"id": "sg:person.010254215452.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010254215452.26"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.bjc.6603033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051210499",
"https://doi.org/10.1038/sj.bjc.6603033"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-008-9925-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008387685",
"https://doi.org/10.1245/s10434-008-9925-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603219",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000027816",
"https://doi.org/10.1038/sj.bjc.6603219"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01655244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021553028",
"https://doi.org/10.1007/bf01655244"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00268-007-9123-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000508059",
"https://doi.org/10.1007/s00268-007-9123-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00268-006-0103-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039331452",
"https://doi.org/10.1007/s00268-006-0103-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604093",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042659170",
"https://doi.org/10.1038/sj.bjc.6604093"
],
"type": "CreativeWork"
}
],
"datePublished": "2009-01-06",
"datePublishedReg": "2009-01-06",
"description": "BackgroundPortal vein embolisation (PVE) can be used to increase the remnant liver parenchyma volume before major hepatectomy but may stimulate tumour growth. The pattern of disease recurrence and long-term survival has not been adequately addressed.MethodsOver a period of 7\u00a0years 36 patients underwent preoperative PVE before resection of four or more liver segments for colorectal cancer (CRC) liver metastases. PVE was performed when the future liver remnant (FLR) assessed by magnetic resonance imaging (MRI) scan volumetry was less than 30%. Disease-free and overall survival was compared with a control group (65 patients) undergoing extended right/right hepatectomy for CRC metastases without PVE during the same time period.ResultsPVE was successful in all patients. PVE increased the median FLR volume by 37% [295\u00a0ml (22%) to 404\u00a0ml (32%), p\u00a0<\u00a00.0001]. 61% of patients undergoing PVE proceeded to liver resection (n\u00a0=\u00a022). Twelve patients (33%) developed disease progression following PVE. The 5-year survival after liver resection with PVE was 25%, compared with 50% without PVE. The 5-year disease-free survival was 30% post PVE and 50% without PVE.ConclusionWe conclude that PVE significantly increases the future liver remnant. Only two-thirds of patients proceed to resection because of disease progression. Long-term survival is less than in patients who do not require PVE. The effect of PVE on tumour growth requires investigation.",
"genre": "article",
"id": "sg:pub.10.1245/s10434-008-0269-4",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1105545",
"issn": [
"1068-9265",
"1534-4681"
],
"name": "Annals of Surgical Oncology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"keywords": [
"future liver remnant",
"long-term survival",
"major hepatectomy",
"disease recurrence",
"disease progression",
"tumor growth",
"colorectal cancer liver metastases",
"more liver segments",
"portal vein embolisation",
"cancer liver metastases",
"disease-free survival",
"effect of PVE",
"preoperative PVE",
"right hepatectomy",
"FLR volume",
"liver resection",
"future liver",
"colorectal metastases",
"liver metastases",
"overall survival",
"CRC metastasis",
"liver remnant",
"parenchyma volume",
"liver segments",
"term survival",
"patients",
"resection",
"control group",
"same time period",
"metastasis",
"hepatectomy",
"survival",
"embolisation",
"recurrence",
"two-thirds",
"progression",
"PVE",
"disease",
"liver",
"volumetry",
"time period",
"period",
"ConclusionWe",
"volume",
"group",
"effect",
"growth",
"segments",
"patterns",
"remnants",
"investigation"
],
"name": "Long-Term Survival and Disease Recurrence Following Portal Vein Embolisation Prior to Major Hepatectomy for Colorectal Metastases",
"pagination": "1202",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1000291548"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1245/s10434-008-0269-4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"19130138"
]
}
],
"sameAs": [
"https://doi.org/10.1245/s10434-008-0269-4",
"https://app.dimensions.ai/details/publication/pub.1000291548"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:26",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_498.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1245/s10434-008-0269-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-008-0269-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-008-0269-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-008-0269-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-008-0269-4'
This table displays all metadata directly associated to this object as RDF triples.
246 TRIPLES
22 PREDICATES
101 URIs
86 LITERALS
24 BLANK NODES