High-Resolution Anoscopy in the Diagnosis of Anal Cancer Precursor Lesions in Renal Graft Recipients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-05

AUTHORS

Ivan Tramujas da Costa e Silva, Luiz Carlos de Lima Ferreira, Felicidad Santos Gimenez, Ricardo Alexandre Gonçalves Guimarães, Luciana Botinelly Fujimoto, Celso Rômulo Barbosa Cabral, Renzo Venturim Mozzer, Larissa de Souza Atala

ABSTRACT

BACKGROUND: Renal graft recipients are one of the population groups known to be at high risk of developing anal cancer. This study investigated the presence of subclinical anal squamous intraepithelial lesions and the diagnostic ability of high-resolution anoscopy in detecting these lesions in renal graft recipients followed-up in Manaus. METHODS: In a cross-sectional study, 50 renal graft recipients were interviewed and submitted to high-resolution anoscopy with biopsies of acetowhite lesions or of the anal transition zone mucosa when acetowhitening was absent. Considering the histopathological reports of the examined anal specimens as the gold standard, the diagnostic validation and precision measures of high-resolution anoscopy were calculated as well as the prevalence of anal squamous intraepithelial lesions in the studied population. RESULTS: In 42 renal graft recipients with satisfactory histopathological readings, prevalence of anal squamous intraepithelial lesions or condyloma acuminatum (ASIL-ACU) was 23.81%. Sensitivity of high-resolution anoscopy was 100%; specificity, 65.63%; positive predictive value, 47.62%; negative predictive value, 100%; and kappa coefficient, 0.48. CONCLUSIONS: With a prevalence of 23.81% of subclinical ASIL-ACU lesions, the studied renal graft recipients had all these lesions detected by high-resolution anoscopy, notwithstanding most anal transition zone acetowhitened biopsied areas did not reveal histopathological aspects of anal cancer precursor lesions or condyloma acuminatum. Therefore, greater experience with the diagnostic tool was felt necessary to enhance its positive predictive value, specificity and diagnostic precision. More... »

PAGES

1470-1475

References to SciGraph publications

  • 1997-08. Colposcopic appearance of anal squamous intraepithelial lesions in DISEASES OF THE COLON & RECTUM
  • 2007-01. Anal cancer in renal transplant patients in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1245/s10434-007-9750-8

    DOI

    http://dx.doi.org/10.1245/s10434-007-9750-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028624399

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18299937


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9750-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9750-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9750-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9750-8'


     

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