Ontology type: schema:ScholarlyArticle
2007-07-14
AUTHORSYong Wha Moon, Hei-Cheul Jeung, Sun Young Rha, Nae Choon Yoo, Jae Kyung Roh, Sung Hoon Noh, Byung Soo Kim, Hyun Cheol Chung
ABSTRACTBackgroundWe evaluated the long-term natural history of gastric cancer after radical gastrectomy and adjuvant chemotherapy through a 15-year follow-up study at a single institute.MethodsFive hundred patients with advanced gastric adenocarcinoma who received radical gastrectomy and adjuvant chemotherapy were included in this long-term follow-up study. Patients were evaluated by imaging studies and upper gastrointestinal series or endoscopy every 6 months until the 10th year after surgery. Since then, the patients have been followed yearly in the same manner.ResultsThe median follow-up period was 190.5 months. The recurrence rate in 5-year survivors was 10.8%. The dominant recurrence pattern was peritoneal carcinomatosis within 5 years and distant metastasis after 5 years post gastrectomy. Tumor stage was a clear-cut prognosticator within 5 years post gastrectomy, but was no longer informative in 5–10 years. At this period, only stage IV (IB–IIIB vs IVM0) was a significantly poor prognosticator. After 10 years, second primary cancer (seven cases) became as important an issue as recurrence of primary gastric cancer (six cases).ConclusionsIn patients with gastric carcinoma treated with radical gastrectomy and adjuvant chemotherapy, late recurrence after 5 years post gastrectomy was not rare. Prognosticators were varied depending on the length of time after surgery. Tumor factors including stage were prognosticators within 5 years post gastrectomy, but tumor factors except stage IV had no prognostic value after 5 years. In the 5–10 years post gastrectomy, only stage IV (IB–IIIB vs IVM0) was a poor prognosticator. Also, after 10 years, there were no prognosticators. More... »
PAGES2730-2737
http://scigraph.springernature.com/pub.10.1245/s10434-007-9479-4
DOIhttp://dx.doi.org/10.1245/s10434-007-9479-4
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17632757
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