Ontology type: schema:ScholarlyArticle
2007-08
AUTHORSSherry J. Lim, Janice N. Cormier, Barry W. Feig, Paul F. Mansfield, Robert S. Benjamin, Janet R. Griffin, Judy L. Chase, Peter W. T. Pisters, Raphael E. Pollock, Kelly K. Hunt
ABSTRACTBACKGROUND: Treatment of peritoneal recurrence following surgical resection of intra-abdominal sarcomas presents a significant challenge to clinicians. Historically, treatment with systemic chemotherapy has been ineffective and surgical resection alone has not been durable. We prospectively evaluated the feasibility of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin (CDDP) alone or in combination with mitoxantrone (MITOX) for the treatment of sarcomatosis. METHODS: Two phase I trials of HIPEC were conducted (1998-2003). Eligible patients with evidence of sarcomatosis underwent cytoreductive surgery followed by HIPEC. In the first trial, CDDP dosing was established as 90 mg/m2 with a perfusate time of 90 minutes and temperature of 41 degrees C. In the second trial, MITOX (20 mg/m2) was instilled following perfusion with CDDP. Toxicity, efficacy, and quality of life (QOL) were evaluated. RESULTS: A total of 28 patients were enrolled in the two trials. We noted a higher overall toxicity score and complication rate with combination CDDP/MITOX versus CDDP alone and shorter overall survival duration (5.5 months vs 16.9 months, respectively). In addition, local recurrence rates were similar in both groups (CDDP 79% vs CDDP/MITOX 68%). As expected, QOL scores at 6-8 weeks following HIPEC were 15-25% lower than the baseline scores; however, they returned to baseline at 3-6 months. CONCLUSIONS: Although the HIPEC technique is feasible for patients with sarcomatosis, it is associated with significant toxicity and limited clinical benefit. Combination CDDP/MITOX failed to demonstrate any benefit over CDDP alone; moreover, there was an increase in toxicity. More... »
PAGES2309-2318
http://scigraph.springernature.com/pub.10.1245/s10434-007-9463-z
DOIhttp://dx.doi.org/10.1245/s10434-007-9463-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1025743805
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17541691
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemotherapy, Cancer, Regional Perfusion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cisplatin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clinical Trials, Phase I as Topic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Combined Modality Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Disease-Free Survival",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Therapy, Combination",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Feasibility Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Follow-Up Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hyperthermia, Induced",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mitoxantrone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Peritoneal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quality of Life",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sarcoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Lim",
"givenName": "Sherry J.",
"id": "sg:person.014102034207.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014102034207.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Cormier",
"givenName": "Janice N.",
"id": "sg:person.0730564335.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730564335.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Feig",
"givenName": "Barry W.",
"id": "sg:person.0634233332.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634233332.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Mansfield",
"givenName": "Paul F.",
"id": "sg:person.01155004373.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155004373.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Benjamin",
"givenName": "Robert S.",
"id": "sg:person.01200333274.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200333274.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Griffin",
"givenName": "Janet R.",
"id": "sg:person.01075127213.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075127213.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Division of Pharmacy, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Chase",
"givenName": "Judy L.",
"id": "sg:person.0660127632.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660127632.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Pisters",
"givenName": "Peter W. T.",
"id": "sg:person.01075456557.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075456557.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Pollock",
"givenName": "Raphael E.",
"id": "sg:person.07756432137.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07756432137.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "The University of Texas MD Anderson Cancer Center",
"id": "https://www.grid.ac/institutes/grid.240145.6",
"name": [
"Department of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA"
],
"type": "Organization"
},
"familyName": "Hunt",
"givenName": "Kelly K.",
"id": "sg:person.01340214713.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340214713.66"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/jso.20597",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000497965"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2003.03.067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003121272",
"https://doi.org/10.1245/aso.2003.03.067"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2003.03.067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003121272",
"https://doi.org/10.1245/aso.2003.03.067"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-2388(199804/05)14:3<254::aid-ssu10>3.0.co;2-u",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003924707"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199201000-00010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004262128"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199201000-00010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004262128"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2003.01.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005309899",
"https://doi.org/10.1245/aso.2003.01.018"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2003.01.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005309899",
"https://doi.org/10.1245/aso.2003.01.018"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2004.10.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007908968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19910715)68:2<321::aid-cncr2820680219>3.0.co;2-b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008329866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21264",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009613889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21264",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009613889"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.138.1.26",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010550017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199007000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010706730"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199007000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010706730"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199007000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010706730"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.20192",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011717958"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19930715)72:2<486::aid-cncr2820720226>3.0.co;2-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013447745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(97)08165-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014870691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.139.1.20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014998894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/02656739609022512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015724266"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2004.07.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016233423",
"https://doi.org/10.1245/aso.2004.07.002"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2004.07.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016233423",
"https://doi.org/10.1245/aso.2004.07.002"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.22239",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016779009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000197702.46394.16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019731745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000197702.46394.16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019731745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000197702.46394.16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019731745"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00003088-199018050-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022455282",
"https://doi.org/10.2165/00003088-199018050-00003"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejso.2004.02.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023782957"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.10176",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023852130"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/ejso.2000.0978",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024449582"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa052985",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025728214"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)00375-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028972994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.4609",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030024396"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005650-199206000-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030545431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005650-199206000-00002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030545431"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10434-999-0645-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030656828",
"https://doi.org/10.1007/s10434-999-0645-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejso.2005.04.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031124000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2006.03.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031355557",
"https://doi.org/10.1245/aso.2006.03.045"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/aso.2006.03.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031355557",
"https://doi.org/10.1245/aso.2006.03.045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(20000101)88:1<66::aid-cncr10>3.0.co;2-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033331661"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-7404(00)00026-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033808814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1055-3207(03)00030-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034568006"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000133183.15705.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035785933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000133183.15705.71",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035785933"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10434-006-9708-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035920713",
"https://doi.org/10.1007/s10434-006-9708-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10434-006-9708-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035920713",
"https://doi.org/10.1007/s10434-006-9708-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.10504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040463386"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0305-7372(83)90008-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042300572"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199504000-00010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042598431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-199504000-00010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042598431"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/annonc/mdf019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046351955"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/j.gassur.2005.06.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048953735",
"https://doi.org/10.1016/j.gassur.2005.06.016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/ejso.2000.1033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049110558"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21845",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050784429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.21845",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050784429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001813-200203000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052158691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00001813-200203000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052158691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/ejso.2000.1038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052551669"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00417837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052734196",
"https://doi.org/10.1007/bf00417837"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00417837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052734196",
"https://doi.org/10.1007/bf00417837"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(92)90712-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052747333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.138.3.248",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053165935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/092986706776872970",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069160687"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076364031",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081424686",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081948903",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082783224",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1993.11.3.570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082809601"
],
"type": "CreativeWork"
}
],
"datePublished": "2007-08",
"datePublishedReg": "2007-08-01",
"description": "BACKGROUND: Treatment of peritoneal recurrence following surgical resection of intra-abdominal sarcomas presents a significant challenge to clinicians. Historically, treatment with systemic chemotherapy has been ineffective and surgical resection alone has not been durable. We prospectively evaluated the feasibility of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin (CDDP) alone or in combination with mitoxantrone (MITOX) for the treatment of sarcomatosis.\nMETHODS: Two phase I trials of HIPEC were conducted (1998-2003). Eligible patients with evidence of sarcomatosis underwent cytoreductive surgery followed by HIPEC. In the first trial, CDDP dosing was established as 90 mg/m2 with a perfusate time of 90 minutes and temperature of 41 degrees C. In the second trial, MITOX (20 mg/m2) was instilled following perfusion with CDDP. Toxicity, efficacy, and quality of life (QOL) were evaluated.\nRESULTS: A total of 28 patients were enrolled in the two trials. We noted a higher overall toxicity score and complication rate with combination CDDP/MITOX versus CDDP alone and shorter overall survival duration (5.5 months vs 16.9 months, respectively). In addition, local recurrence rates were similar in both groups (CDDP 79% vs CDDP/MITOX 68%). As expected, QOL scores at 6-8 weeks following HIPEC were 15-25% lower than the baseline scores; however, they returned to baseline at 3-6 months.\nCONCLUSIONS: Although the HIPEC technique is feasible for patients with sarcomatosis, it is associated with significant toxicity and limited clinical benefit. Combination CDDP/MITOX failed to demonstrate any benefit over CDDP alone; moreover, there was an increase in toxicity.",
"genre": "research_article",
"id": "sg:pub.10.1245/s10434-007-9463-z",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1105545",
"issn": [
"1068-9265",
"1534-4681"
],
"name": "Annals of Surgical Oncology",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "Toxicity and Outcomes Associated with Surgical Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Patients with Sarcomatosis",
"pagination": "2309-2318",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"7aa56e5cffceff49294786d1ba3a7c15d668cf86449194390a78d75213ef96b9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"17541691"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9420840"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1245/s10434-007-9463-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1025743805"
]
}
],
"sameAs": [
"https://doi.org/10.1245/s10434-007-9463-z",
"https://app.dimensions.ai/details/publication/pub.1025743805"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T01:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000499.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1245/s10434-007-9463-z"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9463-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9463-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9463-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-007-9463-z'
This table displays all metadata directly associated to this object as RDF triples.
387 TRIPLES
21 PREDICATES
104 URIs
44 LITERALS
32 BLANK NODES