Correlation Between Melphalan Pharmacokinetics and Hepatic Toxicity Following Hyperthermic Isolated Liver Perfusion for Unresectable Metastatic Disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

Simone Mocellin, Pierluigi Pilati, Pierpaolo Da Pian, Marco Forlin, Susanna Corazzina, Carlo Riccardo Rossi, Federico Innocente, Carlo Ori, Dario Casara, Francesca Ujka, Donato Nitti, Mario Lise

ABSTRACT

BACKGROUND: In the present work, we report on the results of our pilot study of hyperthermic isolated hepatic perfusion (IHP) with melphalan alone for patients with unresectable metastatic liver tumors refractory to conventional treatments, with particular regard to the correlation between pharmacokinetic findings and hepatic toxicity. PATIENTS AND METHODS: Inclusion criteria were unresectable liver metastases, hepatic parenchyma replacement More... »

PAGES

802-809

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/s10434-006-9108-7

DOI

http://dx.doi.org/10.1245/s10434-006-9108-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043043471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17103263


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemical and Drug Induced Liver Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Cancer, Regional Perfusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperthermia, Induced", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melphalan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mocellin", 
        "givenName": "Simone", 
        "id": "sg:person.01370531503.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531503.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy", 
            "Clinica Chirurgica 2, Dipartimento di Scienze Oncologiche e Chirurgiche, Universit\u00e0 di Padova, Via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pilati", 
        "givenName": "Pierluigi", 
        "id": "sg:person.01013644041.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013644041.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pian", 
        "givenName": "Pierpaolo Da", 
        "id": "sg:person.01366203007.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366203007.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forlin", 
        "givenName": "Marco", 
        "id": "sg:person.01062207331.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062207331.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corazzina", 
        "givenName": "Susanna", 
        "id": "sg:person.01274724106.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274724106.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Carlo Riccardo", 
        "id": "sg:person.013321165112.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Anesthesiology and Pharmacology, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Innocente", 
        "givenName": "Federico", 
        "id": "sg:person.0655241320.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655241320.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Anesthesiology and Pharmacology, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ori", 
        "givenName": "Carlo", 
        "id": "sg:person.01343671545.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343671545.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Department of Radiotherapy, Section of Nuclear Medicine, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casara", 
        "givenName": "Dario", 
        "id": "sg:person.01357415215.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357415215.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Laboratory and Clinical Medicine, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ujka", 
        "givenName": "Francesca", 
        "id": "sg:person.0617320670.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617320670.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nitti", 
        "givenName": "Donato", 
        "id": "sg:person.0664577705.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664577705.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Padua", 
          "id": "https://www.grid.ac/institutes/grid.5608.b", 
          "name": [
            "Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lise", 
        "givenName": "Mario", 
        "id": "sg:person.01247543214.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247543214.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00008390-199606000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010757623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199606000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010757623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-199606000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010757623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cytogfr.2004.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012999016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/msy.2001.110365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014846419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(00)00419-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017555993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020070016", 
          "https://doi.org/10.1054/bjoc.2000.1175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-80460-1_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020581706", 
          "https://doi.org/10.1007/978-3-642-80460-1_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006231-200401000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021581015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006231-200401000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021581015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.gassur.2003.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022808153", 
          "https://doi.org/10.1016/j.gassur.2003.11.005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.surg.2004.06.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024128658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/aso.2005.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024944491", 
          "https://doi.org/10.1245/aso.2005.05.003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026375950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200402000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029066423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200402000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029066423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0039-6109(03)00233-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033694278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/1120009x.2004.11782381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037658470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.4308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039475841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.5-5-416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042423370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.2002.1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042988920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.2002.1328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042988920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/ejso.1998.0623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047410057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-004-7430-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047963884", 
          "https://doi.org/10.1007/s00268-004-7430-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.9-6-653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052088364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2004.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052553380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2388(199804/05)14:3<262::aid-ssu11>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052958224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/1761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070914045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074689110", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076617274", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1992.10.1.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077366746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.4.1479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083246644"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-02", 
    "datePublishedReg": "2007-02-01", 
    "description": "BACKGROUND: In the present work, we report on the results of our pilot study of hyperthermic isolated hepatic perfusion (IHP) with melphalan alone for patients with unresectable metastatic liver tumors refractory to conventional treatments, with particular regard to the correlation between pharmacokinetic findings and hepatic toxicity.\nPATIENTS AND METHODS: Inclusion criteria were unresectable liver metastases, hepatic parenchyma replacement 
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/s10434-006-9108-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/s10434-006-9108-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/s10434-006-9108-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/s10434-006-9108-7'


 

This table displays all metadata directly associated to this object as RDF triples.

290 TRIPLES      21 PREDICATES      70 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1245/s10434-006-9108-7 schema:about N05f73534e70e47608c806f6dc173323e
2 N2153422498af4f5da554ce8a649082ba
3 N4c80d8434a074a5e8386b936591c0689
4 N6dd9fd06c7804d5286cc2317acd2a482
5 N72ff3bbee895456d8273d1b4dde3b110
6 N7a25eaf88a274bc68c11381eb70b80d7
7 Na41d6ab20ac44b6aad89b7475e705b62
8 Naab3b9bd839a4ef89a4757508468d49a
9 Nabd91cc56b274898ad4aa5831dc67065
10 Nb34812e8762844868e804b82492d8980
11 Ncc33b052e0684c50abaa24bebeb344ae
12 Ndc32e13448324cfdb41fc488ef7eede8
13 Ned4878f0c6a54073ada36a7295d67aa9
14 Nf2c949999de2491ebb73c118d6afd34e
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author Nf086a05e16e64f3086fe321c5cda9651
18 schema:citation sg:pub.10.1007/978-3-642-80460-1_11
19 sg:pub.10.1007/s00268-004-7430-4
20 sg:pub.10.1016/j.gassur.2003.11.005
21 sg:pub.10.1054/bjoc.2000.1175
22 sg:pub.10.1245/aso.2005.05.003
23 https://app.dimensions.ai/details/publication/pub.1074689110
24 https://app.dimensions.ai/details/publication/pub.1076617274
25 https://doi.org/10.1002/(sici)1098-2388(199804/05)14:3<262::aid-ssu11>3.0.co;2-w
26 https://doi.org/10.1002/bjs.4308
27 https://doi.org/10.1002/cncr.10686
28 https://doi.org/10.1016/j.cytogfr.2004.11.001
29 https://doi.org/10.1016/j.ejca.2004.04.009
30 https://doi.org/10.1016/j.surg.2004.06.044
31 https://doi.org/10.1016/s0039-6109(03)00233-0
32 https://doi.org/10.1016/s1470-2045(00)00419-8
33 https://doi.org/10.1053/ejso.1998.0623
34 https://doi.org/10.1053/ejso.2002.1328
35 https://doi.org/10.1067/msy.2001.110365
36 https://doi.org/10.1080/1120009x.2004.11782381
37 https://doi.org/10.1097/00006231-200401000-00009
38 https://doi.org/10.1097/00008390-199606000-00010
39 https://doi.org/10.1097/00008390-200402000-00011
40 https://doi.org/10.1200/jco.1992.10.1.52
41 https://doi.org/10.1200/jco.1998.16.4.1479
42 https://doi.org/10.1634/theoncologist.5-5-416
43 https://doi.org/10.1634/theoncologist.9-6-653
44 https://doi.org/10.2741/1761
45 schema:datePublished 2007-02
46 schema:datePublishedReg 2007-02-01
47 schema:description BACKGROUND: In the present work, we report on the results of our pilot study of hyperthermic isolated hepatic perfusion (IHP) with melphalan alone for patients with unresectable metastatic liver tumors refractory to conventional treatments, with particular regard to the correlation between pharmacokinetic findings and hepatic toxicity. PATIENTS AND METHODS: Inclusion criteria were unresectable liver metastases, hepatic parenchyma replacement <or=50%, normal liver function, and previous failure of at least one conventional treatment. IHP was performed under hyperthermic conditions with melphalan (1.5 mg/kg body weight). Completeness of vascular isolation of the liver and drug distribution volumes of the perfusion circuit were assessed by a radiolabeled albumin-based method. Drug concentrations in perfusate and plasma were measured by means of high-performance liquid chromatography (HPLC). RESULTS: Twenty patients with unresectable liver metastases underwent IHP. No intraoperative mortality occurred. Treatment-related systemic toxicity was minimal and reversible. Three patients (15%) experienced grade 4 hepatic toxicity and died due to liver failure and subsequent multiorgan failure. Other six patients had significant (grade 3-4) but transitory hepatic toxicity. Complete and partial responses were observed in three and nine out of 17 evaluable patients, respectively (overall response rate = 70%). The pharmacokinetics study showed a 3% mean perfusate-to-plasma drug leakage (range 1-6%). Logistic regression analysis showed that drug concentration in the perfusate circuit, but not preoperative tests, significantly and independently correlated with hepatic toxicity (P = 0.028). CONCLUSIONS: Following melphalan-based IHP, objective tumor regression could be observed in a remarkable percentage of patients refractory to standard treatments. However, hepatic toxicity and related mortality were significant. Our findings suggest that drug dosage personalization based on the measurement of drug distribution volumes might minimize hepatic toxicity.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf Na8b72961025a4ead86fb154f87902a21
52 Ne4560aacf13242328cb9d6be6a757e03
53 sg:journal.1105545
54 schema:name Correlation Between Melphalan Pharmacokinetics and Hepatic Toxicity Following Hyperthermic Isolated Liver Perfusion for Unresectable Metastatic Disease
55 schema:pagination 802-809
56 schema:productId N38f80c9cf3a34e0397268b8c1e92c04a
57 N392ea59d59d94f72ab24ce2798e8d751
58 N3cb11a2e71644acfa3d3fee9225ce390
59 N7876b83aedd54cb58e52911d5a414600
60 Nd4162236b87a40c3a468eaa43f8caae5
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043043471
62 https://doi.org/10.1245/s10434-006-9108-7
63 schema:sdDatePublished 2019-04-10T17:29
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nd576ca9ed84140c594b79623aa9f8588
66 schema:url http://link.springer.com/10.1245/s10434-006-9108-7
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N05f73534e70e47608c806f6dc173323e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Chemical and Drug Induced Liver Injury
72 rdf:type schema:DefinedTerm
73 N2153422498af4f5da554ce8a649082ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Liver Neoplasms
75 rdf:type schema:DefinedTerm
76 N38f80c9cf3a34e0397268b8c1e92c04a schema:name doi
77 schema:value 10.1245/s10434-006-9108-7
78 rdf:type schema:PropertyValue
79 N392ea59d59d94f72ab24ce2798e8d751 schema:name readcube_id
80 schema:value cd07d059dce4922160f1f42fd6e44ded0405f81605eb6dcbd41cc0a588b47826
81 rdf:type schema:PropertyValue
82 N3cb11a2e71644acfa3d3fee9225ce390 schema:name nlm_unique_id
83 schema:value 9420840
84 rdf:type schema:PropertyValue
85 N45a56810e0854f7ea992071dcbc00c8c rdf:first sg:person.01343671545.60
86 rdf:rest N72e2dcc61f774ad69862e58f5af3faeb
87 N4a8ffba2044a49eebd110ff6e0294a30 rdf:first sg:person.01013644041.08
88 rdf:rest N6466325d206a433cb32c770f68907295
89 N4bdad35b62994b8ca1c50cb612970ed5 rdf:first sg:person.01062207331.49
90 rdf:rest Nd63c3c7228fc41e7a136e0ac9fb9de8d
91 N4c80d8434a074a5e8386b936591c0689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Chemotherapy, Cancer, Regional Perfusion
93 rdf:type schema:DefinedTerm
94 N58dd3228dda547f19088a39c180eedac rdf:first sg:person.0617320670.24
95 rdf:rest Nd72b24b4f59b4f83a8764088bff0e38d
96 N6466325d206a433cb32c770f68907295 rdf:first sg:person.01366203007.04
97 rdf:rest N4bdad35b62994b8ca1c50cb612970ed5
98 N6dd9fd06c7804d5286cc2317acd2a482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Male
100 rdf:type schema:DefinedTerm
101 N72e2dcc61f774ad69862e58f5af3faeb rdf:first sg:person.01357415215.32
102 rdf:rest N58dd3228dda547f19088a39c180eedac
103 N72ff3bbee895456d8273d1b4dde3b110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Feasibility Studies
105 rdf:type schema:DefinedTerm
106 N7876b83aedd54cb58e52911d5a414600 schema:name pubmed_id
107 schema:value 17103263
108 rdf:type schema:PropertyValue
109 N7a25eaf88a274bc68c11381eb70b80d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Middle Aged
111 rdf:type schema:DefinedTerm
112 N83149f0e11754e1b88864c2c1bfade1a rdf:first sg:person.013321165112.41
113 rdf:rest Nd4593f2c4cec4ad3bf5299e209d8628b
114 Na1c18273bf81424da86283a8e42100ac rdf:first sg:person.01247543214.38
115 rdf:rest rdf:nil
116 Na41d6ab20ac44b6aad89b7475e705b62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Antineoplastic Agents, Alkylating
118 rdf:type schema:DefinedTerm
119 Na8b72961025a4ead86fb154f87902a21 schema:issueNumber 2
120 rdf:type schema:PublicationIssue
121 Naab3b9bd839a4ef89a4757508468d49a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Melphalan
123 rdf:type schema:DefinedTerm
124 Nabd91cc56b274898ad4aa5831dc67065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Pilot Projects
126 rdf:type schema:DefinedTerm
127 Nb34812e8762844868e804b82492d8980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 Ncc33b052e0684c50abaa24bebeb344ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Hyperthermia, Induced
132 rdf:type schema:DefinedTerm
133 Nd4162236b87a40c3a468eaa43f8caae5 schema:name dimensions_id
134 schema:value pub.1043043471
135 rdf:type schema:PropertyValue
136 Nd4593f2c4cec4ad3bf5299e209d8628b rdf:first sg:person.0655241320.76
137 rdf:rest N45a56810e0854f7ea992071dcbc00c8c
138 Nd576ca9ed84140c594b79623aa9f8588 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Nd63c3c7228fc41e7a136e0ac9fb9de8d rdf:first sg:person.01274724106.53
141 rdf:rest N83149f0e11754e1b88864c2c1bfade1a
142 Nd72b24b4f59b4f83a8764088bff0e38d rdf:first sg:person.0664577705.70
143 rdf:rest Na1c18273bf81424da86283a8e42100ac
144 Ndc32e13448324cfdb41fc488ef7eede8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adult
146 rdf:type schema:DefinedTerm
147 Ne4560aacf13242328cb9d6be6a757e03 schema:volumeNumber 14
148 rdf:type schema:PublicationVolume
149 Ned4878f0c6a54073ada36a7295d67aa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Aged
151 rdf:type schema:DefinedTerm
152 Nf086a05e16e64f3086fe321c5cda9651 rdf:first sg:person.01370531503.96
153 rdf:rest N4a8ffba2044a49eebd110ff6e0294a30
154 Nf2c949999de2491ebb73c118d6afd34e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
161 schema:name Clinical Sciences
162 rdf:type schema:DefinedTerm
163 sg:journal.1105545 schema:issn 1068-9265
164 1534-4681
165 schema:name Annals of Surgical Oncology
166 rdf:type schema:Periodical
167 sg:person.01013644041.08 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
168 schema:familyName Pilati
169 schema:givenName Pierluigi
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013644041.08
171 rdf:type schema:Person
172 sg:person.01062207331.49 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
173 schema:familyName Forlin
174 schema:givenName Marco
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062207331.49
176 rdf:type schema:Person
177 sg:person.01247543214.38 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
178 schema:familyName Lise
179 schema:givenName Mario
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247543214.38
181 rdf:type schema:Person
182 sg:person.01274724106.53 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
183 schema:familyName Corazzina
184 schema:givenName Susanna
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274724106.53
186 rdf:type schema:Person
187 sg:person.013321165112.41 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
188 schema:familyName Rossi
189 schema:givenName Carlo Riccardo
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013321165112.41
191 rdf:type schema:Person
192 sg:person.01343671545.60 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
193 schema:familyName Ori
194 schema:givenName Carlo
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343671545.60
196 rdf:type schema:Person
197 sg:person.01357415215.32 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
198 schema:familyName Casara
199 schema:givenName Dario
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357415215.32
201 rdf:type schema:Person
202 sg:person.01366203007.04 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
203 schema:familyName Pian
204 schema:givenName Pierpaolo Da
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366203007.04
206 rdf:type schema:Person
207 sg:person.01370531503.96 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
208 schema:familyName Mocellin
209 schema:givenName Simone
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370531503.96
211 rdf:type schema:Person
212 sg:person.0617320670.24 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
213 schema:familyName Ujka
214 schema:givenName Francesca
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617320670.24
216 rdf:type schema:Person
217 sg:person.0655241320.76 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
218 schema:familyName Innocente
219 schema:givenName Federico
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655241320.76
221 rdf:type schema:Person
222 sg:person.0664577705.70 schema:affiliation https://www.grid.ac/institutes/grid.5608.b
223 schema:familyName Nitti
224 schema:givenName Donato
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664577705.70
226 rdf:type schema:Person
227 sg:pub.10.1007/978-3-642-80460-1_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020581706
228 https://doi.org/10.1007/978-3-642-80460-1_11
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s00268-004-7430-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047963884
231 https://doi.org/10.1007/s00268-004-7430-4
232 rdf:type schema:CreativeWork
233 sg:pub.10.1016/j.gassur.2003.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022808153
234 https://doi.org/10.1016/j.gassur.2003.11.005
235 rdf:type schema:CreativeWork
236 sg:pub.10.1054/bjoc.2000.1175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020070016
237 https://doi.org/10.1054/bjoc.2000.1175
238 rdf:type schema:CreativeWork
239 sg:pub.10.1245/aso.2005.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024944491
240 https://doi.org/10.1245/aso.2005.05.003
241 rdf:type schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1074689110 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1076617274 schema:CreativeWork
244 https://doi.org/10.1002/(sici)1098-2388(199804/05)14:3<262::aid-ssu11>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1052958224
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/bjs.4308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039475841
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/cncr.10686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026375950
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.cytogfr.2004.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012999016
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.ejca.2004.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052553380
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.surg.2004.06.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024128658
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0039-6109(03)00233-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033694278
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s1470-2045(00)00419-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017555993
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1053/ejso.1998.0623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047410057
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1053/ejso.2002.1328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042988920
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1067/msy.2001.110365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014846419
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1080/1120009x.2004.11782381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037658470
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1097/00006231-200401000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021581015
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1097/00008390-199606000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010757623
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1097/00008390-200402000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029066423
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1200/jco.1992.10.1.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077366746
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1200/jco.1998.16.4.1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083246644
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1634/theoncologist.5-5-416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042423370
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1634/theoncologist.9-6-653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052088364
281 rdf:type schema:CreativeWork
282 https://doi.org/10.2741/1761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070914045
283 rdf:type schema:CreativeWork
284 https://www.grid.ac/institutes/grid.5608.b schema:alternateName University of Padua
285 schema:name Clinica Chirurgica 2, Dipartimento di Scienze Oncologiche e Chirurgiche, Università di Padova, Via Giustiniani 2, 35128, Padova, Italy
286 Department of Anesthesiology and Pharmacology, University of Padova, via Giustiniani 2, 35128, Padova, Italy
287 Department of Radiotherapy, Section of Nuclear Medicine, University of Padova, via Giustiniani 2, 35128, Padova, Italy
288 Laboratory and Clinical Medicine, University of Padova, via Giustiniani 2, 35128, Padova, Italy
289 Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, via Giustiniani 2, 35128, Padova, Italy
290 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...