Ontology type: schema:ScholarlyArticle
2004-11
AUTHORSOktar Asoglu, Mustafa M. Ugurlu, Kay Blanchard, Clive S. Grant, Carol Reynolds, Steven S. Cha, John H. Donohue
ABSTRACTBACKGROUND: Malignant phyllodes tumor (MPT) is a rare but aggressive breast malignancy. The aim of this study was to evaluate parameters that influence outcome in patients with MPT. METHODS: Fifty women were diagnosed with MPT of the breast and treated between August 1971 and July 2000. All medical records were reviewed retrospectively. The Cox regression model was used for multivariate analysis. RESULTS: Tumors were classified as borderline (6%), low grade (32%), or high grade (62%). The median patient age was 46 years (range, 14-77 years). The median tumor diameter was 3.5 cm (range, 1.5-18 cm). Twenty-two patients had wide local excision (WLE), and 28 patients had mastectomy. The median follow-up was 91 months (range, 12-360 months). Local recurrence (LR) occurred in 16 patients (32%) an average of 26 months after surgery (median, 17 months; range, 3-72 months). Distant metastasis occurred in 13 patients (26%) at an average of 53.4 months (median, 36 months; range, 4-177 months). Sixteen (32%) patients have died of their disease. LR was significantly increased with stromal overgrowth (P < .0001), large tumor size (P = .0177), and surgical margins <1 cm (P = .0120), but not with WLE (P = .5099). Stromal overgrowth was the only independent variable predictive of systemic metastasis (P < .0001) and patient survival (P < .0001). CONCLUSIONS: Stromal overgrowth in MPT carries a grave prognosis. Close surgical margins and large tumor size, but not type of operation, significantly increased LR. Either WLE with adequate margins or mastectomy is an appropriate treatment for patients with MPT. More... »
PAGES1011-1017
http://scigraph.springernature.com/pub.10.1245/aso.2004.02.001
DOIhttp://dx.doi.org/10.1245/aso.2004.02.001
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017919258
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15525831
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Recurrence, Local",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phyllodes Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Asoglu",
"givenName": "Oktar",
"id": "sg:person.01057745754.60",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057745754.60"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Ugurlu",
"givenName": "Mustafa M.",
"id": "sg:person.01136507141.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136507141.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Blanchard",
"givenName": "Kay",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Grant",
"givenName": "Clive S.",
"id": "sg:person.01234176105.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234176105.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Reynolds",
"givenName": "Carol",
"id": "sg:person.011452350717.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011452350717.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Cha",
"givenName": "Steven S.",
"id": "sg:person.011657745222.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011657745222.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Mayo Clinic",
"id": "https://www.grid.ac/institutes/grid.66875.3a",
"name": [
"From the Department of Surgery (OA, MMU, KB, CSG, JHD), Department of Laboratory Medicine and Pathology (CR), and Division of Biostatistics (SSC), Mayo Clinic and Mayo Foundation, Rochester, Minnesota."
],
"type": "Organization"
},
"familyName": "Donohue",
"givenName": "John H.",
"id": "sg:person.0652167730.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652167730.89"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/1097-0142(19920101)69:1<141::aid-cncr2820690125>3.0.co;2-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001880589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19890601)63:11<2088::aid-cncr2820631103>3.0.co;2-c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002075693"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197411000-00016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003602404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197411000-00016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003602404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197411000-00016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003602404"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0959-8049(93)90067-p",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004851191"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005980831359",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005995940",
"https://doi.org/10.1023/a:1005980831359"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-7404(03)00005-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006064453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-7404(03)00005-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006064453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197604)37:4<1737::aid-cncr2820370419>3.0.co;2-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008874434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(05)80119-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009887175"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9610(05)80849-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009916883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/pmj.77.909.428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016117387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/pmj.77.909.428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016117387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.2930330306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017105135"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19861115)58:10<2282::aid-cncr2820581021>3.0.co;2-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017389252"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archsurg.134.5.487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017701477"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-7404(00)00022-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019573789"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.1995.tb00212.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021509019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.1995.tb00212.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021509019"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.2930560213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025959576"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19890615)63:12<2532::aid-cncr2820631229>3.0.co;2-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026311834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197805)41:5<1974::aid-cncr2820410543>3.0.co;2-c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026688905"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0002-9610(87)90601-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029171139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1524-4741.2001.07606.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029351555"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/ejso.2001.1207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030720101"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1097-0142(19960301)77:5<910::aid-cncr16>3.0.co;2-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032187842"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(197609)38:3<1402::aid-cncr2820380346>3.0.co;2-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039390523"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197104000-00007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045327088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000658-197104000-00007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045327088"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(196712)20:12<2090::aid-cncr2820201206>3.0.co;2-l",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045567898"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02133961",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047278514",
"https://doi.org/10.1007/bf02133961"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02133961",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047278514",
"https://doi.org/10.1007/bf02133961"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19911101)68:9<2017::aid-cncr2820680929>3.0.co;2-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047356896"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.2930450111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047579298"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1006260225618",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048422507",
"https://doi.org/10.1023/a:1006260225618"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(20001001)89:7<1502::aid-cncr13>3.0.co;2-p",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049943265"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0009-9260(87)80071-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050757173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199801000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122493"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199801000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122493"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000478-199801000-00008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060122493"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075564678",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075670102",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078392826",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078998308",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081102751",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081659874",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082429294",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082617920",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082783765",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082788782",
"type": "CreativeWork"
}
],
"datePublished": "2004-11",
"datePublishedReg": "2004-11-01",
"description": "BACKGROUND: Malignant phyllodes tumor (MPT) is a rare but aggressive breast malignancy. The aim of this study was to evaluate parameters that influence outcome in patients with MPT.\nMETHODS: Fifty women were diagnosed with MPT of the breast and treated between August 1971 and July 2000. All medical records were reviewed retrospectively. The Cox regression model was used for multivariate analysis.\nRESULTS: Tumors were classified as borderline (6%), low grade (32%), or high grade (62%). The median patient age was 46 years (range, 14-77 years). The median tumor diameter was 3.5 cm (range, 1.5-18 cm). Twenty-two patients had wide local excision (WLE), and 28 patients had mastectomy. The median follow-up was 91 months (range, 12-360 months). Local recurrence (LR) occurred in 16 patients (32%) an average of 26 months after surgery (median, 17 months; range, 3-72 months). Distant metastasis occurred in 13 patients (26%) at an average of 53.4 months (median, 36 months; range, 4-177 months). Sixteen (32%) patients have died of their disease. LR was significantly increased with stromal overgrowth (P < .0001), large tumor size (P = .0177), and surgical margins <1 cm (P = .0120), but not with WLE (P = .5099). Stromal overgrowth was the only independent variable predictive of systemic metastasis (P < .0001) and patient survival (P < .0001).\nCONCLUSIONS: Stromal overgrowth in MPT carries a grave prognosis. Close surgical margins and large tumor size, but not type of operation, significantly increased LR. Either WLE with adequate margins or mastectomy is an appropriate treatment for patients with MPT.",
"genre": "research_article",
"id": "sg:pub.10.1245/aso.2004.02.001",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1105545",
"issn": [
"1068-9265",
"1534-4681"
],
"name": "Annals of Surgical Oncology",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "11"
}
],
"name": "Risk Factors for Recurrence and Death After Primary Surgical Treatment of Malignant Phyllodes Tumors",
"pagination": "1011-1017",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5560f14d32f614c221f9be2aaca587b578cde47e4bf5368c72f93e1b133ac1bf"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15525831"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9420840"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1245/aso.2004.02.001"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017919258"
]
}
],
"sameAs": [
"https://doi.org/10.1245/aso.2004.02.001",
"https://app.dimensions.ai/details/publication/pub.1017919258"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:38",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000358_0000000358/records_127435_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=0042561-200411000-00012"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1245/aso.2004.02.001'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1245/aso.2004.02.001'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1245/aso.2004.02.001'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1245/aso.2004.02.001'
This table displays all metadata directly associated to this object as RDF triples.
281 TRIPLES
21 PREDICATES
84 URIs
34 LITERALS
22 BLANK NODES