Persistence of tumor DNA in plasma of breast cancer patients after mastectomy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-01

AUTHORS

Jose M. Silva, Jose M. Garcia, Gemma Dominguez, Javier Silva, Celia Miralles, Blanca Cantos, Santiago Coca, Mariano Provencio, Pilar España, Felix Bonilla

ABSTRACT

BACKGROUND: We investigated tumor DNA changes before and after mastectomy in the plasma of breast cancer patients with no disseminated disease and eventually investigated these changes' relationship to specific pathological parameters of the tumors. METHODS: We studied 41 patients. DNA extracted from tumor and normal breast tissues, mononuclear blood cells, and plasma was used for molecular studies. Alterations in the microsatellite markers D17S855, D17S654, D16S421, TH2, D10S197, and D9S161, as well as point mutations in the p53 gene and aberrant methylation of p16(INK4a), were used to identify and characterize tumor and plasma DNA. A number of tumor clinicopathological parameters were analyzed in each patient. RESULTS: We found that 18 (44%) of the 27 patients with alterations in tumor DNA presented the same plasma DNA alteration before mastectomy, and persistence of the same molecular features was detected in plasma DNA 4 to 6 weeks postmastectomy in 8 (19.5%) patients. Patients with vascular invasion, more than three lymph node metastases, and higher histological grade at diagnosis displayed plasma DNA after mastectomy with a significant difference. CONCLUSIONS: Persistence of plasma DNA with features of tumor DNA may be present after mastectomy in breast cancer patients, and its relation to bad-prognosis histological parameters may suggest undetectable micrometastatic disease. More... »

PAGES

71-76

Identifiers

URI

http://scigraph.springernature.com/pub.10.1245/aso.2002.9.1.71

DOI

http://dx.doi.org/10.1245/aso.2002.9.1.71

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008041745

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11829433


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