Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-05

AUTHORS

Yuan Zhu, Wen Xu, Jiajia Zhang, Youwu Liao, Caleb Kesse Firempong, Michael Adu-Frimpong, Wenwen Deng, Huiyun Zhang, Jiangnan Yu, Ximing Xu

ABSTRACT

The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limonene-SMEDDS (L-SMEDDS). The characteristics of this system assessed in vitro, mainly included determination of particle size distribution, observation of morphology via transmission electron microscopy (TEM), testing of drug release in different dissolution media, and evaluation of stability. The oral bioavailability study in vivo of the formulated limonene was performed in rats with the free limonene as the reference. Compared with the free limonene, the distribution study of L-SMEDDS was conducted in Kunming mice after oral administration. The optimized SMEDDS (ethyl oleate, 14.2%; Cremophor EL, 28.6%; isopropanol, 28.6%; and loaded limonene, 28.6%) under the TEM (about 100 nm) was spherical with no significant variations in size/appearance for 30 days at 4, 25, and 60°C. In comparison with free limonene, higher than 89.0% of limonene was released from SMEDDS within 10 min in different dissolution media. An in vivo study showed a 3.71-fold improved oral bioavailability of the formulated limonene compared to the free limonene. The tissue distribution results showed that limonene predominantly accumulated in the various tissues for the L-SMEDDS compared with the free limonene. Hence, L-SMEDDS could remarkably improve the concentration of limonene in the various organs. These findings hinted that the oral bioavailability of limonene could be improved via an effectual delivery system like SMEDDS. More... »

PAGES

153

Journal

TITLE

AAPS PharmSciTech

ISSUE

4

VOLUME

20

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1208/s12249-019-1361-8

DOI

http://dx.doi.org/10.1208/s12249-019-1361-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113008655

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30915610


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Yuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Wen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jiajia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liao", 
        "givenName": "Youwu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Firempong", 
        "givenName": "Caleb Kesse", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adu-Frimpong", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deng", 
        "givenName": "Wenwen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Huiyun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Jiangnan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jiangsu University", 
          "id": "https://www.grid.ac/institutes/grid.440785.a", 
          "name": [
            "Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Ximing", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jff.2014.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002648334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2013.10.055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002888066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03639049709150551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007277854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.colsurfa.2011.09.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008203131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jff.2012.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009686904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11095-013-1063-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010118445", 
          "https://doi.org/10.1007/s11095-013-1063-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2012.08.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010168690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12249-010-9385-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011618445", 
          "https://doi.org/10.1208/s12249-010-9385-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2012.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011677836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0536.1999.tb06009.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011932372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopha.2004.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012015777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s83520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013177979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/ijn.s83520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013177979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodhyd.2015.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013685956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2012.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014652357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbi.2009.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016088198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2007.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019276053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pbb.2012.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020045849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.seppur.2014.09.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020359218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2011.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022349032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nano.2013.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023221752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026387460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/js9700863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026640216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jff.2014.12.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030845022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-409x(92)90015-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-409x(92)90015-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031065926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jsfa.7002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034397155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2011.08.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035540857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2008.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035544408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01061761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036555799", 
          "https://doi.org/10.1007/bf01061761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2009.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037573118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.intimp.2014.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038224421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2011.04.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041342637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2013.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042526720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.2042-7158.2010.01149.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042864415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jff.2013.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042953470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2016.04.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044654747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2013.05.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044703662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.kjms.2016.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046271155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0731-7085(97)00243-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046503579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12249-009-9281-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050183488", 
          "https://doi.org/10.1208/s12249-009-9281-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ultsonch.2013.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052364649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodhyd.2018.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104125997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2018.09.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106577737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phymed.2018.09.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106577737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2018.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110267283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2018.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1110267283"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-05", 
    "datePublishedReg": "2019-05-01", 
    "description": "The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limonene-SMEDDS (L-SMEDDS). The characteristics of this system assessed in vitro, mainly included determination of particle size distribution, observation of morphology via transmission electron microscopy (TEM), testing of drug release in different dissolution media, and evaluation of stability. The oral bioavailability study in vivo of the formulated limonene was performed in rats with the free limonene as the reference. Compared with the free limonene, the distribution study of L-SMEDDS was conducted in Kunming mice after oral administration. The optimized SMEDDS (ethyl oleate, 14.2%; Cremophor EL, 28.6%; isopropanol, 28.6%; and loaded limonene, 28.6%) under the TEM (about 100\u00a0nm) was spherical with no significant variations in size/appearance for 30\u00a0days at 4, 25, and 60\u00b0C. In comparison with free limonene, higher than 89.0% of limonene was released from SMEDDS within 10\u00a0min in different dissolution media. An in vivo study showed a 3.71-fold improved oral bioavailability of the formulated limonene compared to the free limonene. The tissue distribution results showed that limonene predominantly accumulated in the various tissues for the L-SMEDDS compared with the free limonene. Hence, L-SMEDDS could remarkably improve the concentration of limonene in the various organs. These findings hinted that the oral bioavailability of limonene could be improved via an effectual delivery system like SMEDDS.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1208/s12249-019-1361-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1023420", 
        "issn": [
          "1530-9932"
        ], 
        "name": "AAPS PharmSciTech", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation", 
    "pagination": "153", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "97e40ecc726ed7d9c930a948b1097179d4d714c5b9e2d7588bd6558de0be3710"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30915610"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1208/s12249-019-1361-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113008655"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1208/s12249-019-1361-8", 
      "https://app.dimensions.ai/details/publication/pub.1113008655"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88218_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1208%2Fs12249-019-1361-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1208/s12249-019-1361-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1208/s12249-019-1361-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1208/s12249-019-1361-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1208/s12249-019-1361-8'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      21 PREDICATES      72 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1208/s12249-019-1361-8 schema:about anzsrc-for:10
2 anzsrc-for:1007
3 schema:author N134be731337049bea3cab6fed0c4e691
4 schema:citation sg:pub.10.1007/bf01061761
5 sg:pub.10.1007/s11095-013-1063-y
6 sg:pub.10.1208/s12249-009-9281-7
7 sg:pub.10.1208/s12249-010-9385-0
8 https://doi.org/10.1002/jsfa.7002
9 https://doi.org/10.1016/0169-409x(92)90015-i
10 https://doi.org/10.1016/j.biopha.2004.02.001
11 https://doi.org/10.1016/j.cbi.2009.04.006
12 https://doi.org/10.1016/j.colsurfa.2011.09.048
13 https://doi.org/10.1016/j.ejpb.2011.11.005
14 https://doi.org/10.1016/j.ejpb.2012.10.007
15 https://doi.org/10.1016/j.ejps.2012.04.001
16 https://doi.org/10.1016/j.ejps.2013.08.006
17 https://doi.org/10.1016/j.ejps.2018.11.036
18 https://doi.org/10.1016/j.fitote.2012.08.021
19 https://doi.org/10.1016/j.foodhyd.2015.01.031
20 https://doi.org/10.1016/j.foodhyd.2018.05.041
21 https://doi.org/10.1016/j.ijpharm.2007.03.021
22 https://doi.org/10.1016/j.ijpharm.2008.12.009
23 https://doi.org/10.1016/j.ijpharm.2009.08.035
24 https://doi.org/10.1016/j.ijpharm.2011.04.041
25 https://doi.org/10.1016/j.ijpharm.2011.08.024
26 https://doi.org/10.1016/j.ijpharm.2012.01.004
27 https://doi.org/10.1016/j.ijpharm.2013.05.034
28 https://doi.org/10.1016/j.ijpharm.2013.10.055
29 https://doi.org/10.1016/j.ijpharm.2016.04.059
30 https://doi.org/10.1016/j.intimp.2014.12.001
31 https://doi.org/10.1016/j.jff.2012.11.008
32 https://doi.org/10.1016/j.jff.2013.12.010
33 https://doi.org/10.1016/j.jff.2014.12.030
34 https://doi.org/10.1016/j.jff.2014.12.043
35 https://doi.org/10.1016/j.kjms.2016.12.003
36 https://doi.org/10.1016/j.nano.2013.01.001
37 https://doi.org/10.1016/j.pbb.2012.09.005
38 https://doi.org/10.1016/j.phymed.2018.09.027
39 https://doi.org/10.1016/j.seppur.2014.09.015
40 https://doi.org/10.1016/j.ultsonch.2013.10.013
41 https://doi.org/10.1016/s0731-7085(97)00243-4
42 https://doi.org/10.1021/js9700863
43 https://doi.org/10.1111/j.1600-0536.1999.tb06009.x
44 https://doi.org/10.1111/j.2042-7158.2010.01149.x
45 https://doi.org/10.2147/ijn.s83520
46 https://doi.org/10.3109/03639049709150551
47 schema:datePublished 2019-05
48 schema:datePublishedReg 2019-05-01
49 schema:description The current investigation aimed at formulating self-microemulsifying drug delivery system (SMEDDS) to ameliorate oral bioavailability of a hydrophobic functional ingredient, limonene. Solubility test, compatibility test, and pseudo-ternary phase diagrams (PTPD) were adopted to screen the optimal compositions of limonene-SMEDDS (L-SMEDDS). The characteristics of this system assessed in vitro, mainly included determination of particle size distribution, observation of morphology via transmission electron microscopy (TEM), testing of drug release in different dissolution media, and evaluation of stability. The oral bioavailability study in vivo of the formulated limonene was performed in rats with the free limonene as the reference. Compared with the free limonene, the distribution study of L-SMEDDS was conducted in Kunming mice after oral administration. The optimized SMEDDS (ethyl oleate, 14.2%; Cremophor EL, 28.6%; isopropanol, 28.6%; and loaded limonene, 28.6%) under the TEM (about 100 nm) was spherical with no significant variations in size/appearance for 30 days at 4, 25, and 60°C. In comparison with free limonene, higher than 89.0% of limonene was released from SMEDDS within 10 min in different dissolution media. An in vivo study showed a 3.71-fold improved oral bioavailability of the formulated limonene compared to the free limonene. The tissue distribution results showed that limonene predominantly accumulated in the various tissues for the L-SMEDDS compared with the free limonene. Hence, L-SMEDDS could remarkably improve the concentration of limonene in the various organs. These findings hinted that the oral bioavailability of limonene could be improved via an effectual delivery system like SMEDDS.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf Nb39262cc05e1425ab6e3ceeb1b5ab7fb
54 Nfb32937a9a684b468506be94a58bc922
55 sg:journal.1023420
56 schema:name Self-microemulsifying Drug Delivery System for Improved Oral Delivery of Limonene: Preparation, Characterization, in vitro and in vivo Evaluation
57 schema:pagination 153
58 schema:productId N519570ac7a3e43d392a349deac8c86bb
59 N521b7722685d4dedb7457b3dbd59ab67
60 N5fc2c416491d469bb0141b61203df2d7
61 N743c417238944a0db310a24a0dfd4f03
62 Nd364cb8a00494eddb44d2b4d0f693e28
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113008655
64 https://doi.org/10.1208/s12249-019-1361-8
65 schema:sdDatePublished 2019-04-11T13:07
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N864543acf46e412abd2d6c784331e8de
68 schema:url https://link.springer.com/10.1208%2Fs12249-019-1361-8
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N07268ad916bf4f9d9615893adde99d4d rdf:first Nf7d9663c44bb4fe2a8e45c77677880f0
73 rdf:rest Nd1fed8b369f54b21b94cc29b4aa69dc5
74 N11a7cf0473ff42c895ea58685f2afafa schema:affiliation https://www.grid.ac/institutes/grid.440785.a
75 schema:familyName Adu-Frimpong
76 schema:givenName Michael
77 rdf:type schema:Person
78 N134be731337049bea3cab6fed0c4e691 rdf:first Na653db0120bb43c3abeda91eac9d3090
79 rdf:rest N35d0deef53274311b4505cef55ed1f93
80 N231cb4671ca1421688aac25f3893e659 rdf:first Ne6f491dcafe5497f93dbfcf3339efc98
81 rdf:rest Ndcc5f8dd79b84d51b52680dfcc2f0250
82 N2ea1eb9ea19a4871b42095b6f0a7a30c rdf:first N687f8b2fcc4f4553a1a2b0c258dbd0ef
83 rdf:rest N86cc12e94d094d9197b796cc3e33e9e1
84 N31363375024a43199b84d0eabf4a63b7 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
85 schema:familyName Zhang
86 schema:givenName Huiyun
87 rdf:type schema:Person
88 N35d0deef53274311b4505cef55ed1f93 rdf:first Nb5da24a111224fe3ab0c0b969679d477
89 rdf:rest N231cb4671ca1421688aac25f3893e659
90 N3e809b63a7a14ee1b5df086e0b28beb9 rdf:first N6ef94e5ccd4d41c4a7d2d7d6e4d3b7af
91 rdf:rest rdf:nil
92 N519570ac7a3e43d392a349deac8c86bb schema:name pubmed_id
93 schema:value 30915610
94 rdf:type schema:PropertyValue
95 N521b7722685d4dedb7457b3dbd59ab67 schema:name dimensions_id
96 schema:value pub.1113008655
97 rdf:type schema:PropertyValue
98 N5985f16c0ddc45d982e2bd10e8fb30c8 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
99 schema:familyName Liao
100 schema:givenName Youwu
101 rdf:type schema:Person
102 N5fc2c416491d469bb0141b61203df2d7 schema:name doi
103 schema:value 10.1208/s12249-019-1361-8
104 rdf:type schema:PropertyValue
105 N687f8b2fcc4f4553a1a2b0c258dbd0ef schema:affiliation https://www.grid.ac/institutes/grid.440785.a
106 schema:familyName Deng
107 schema:givenName Wenwen
108 rdf:type schema:Person
109 N6ef94e5ccd4d41c4a7d2d7d6e4d3b7af schema:affiliation https://www.grid.ac/institutes/grid.440785.a
110 schema:familyName Xu
111 schema:givenName Ximing
112 rdf:type schema:Person
113 N743c417238944a0db310a24a0dfd4f03 schema:name nlm_unique_id
114 schema:value 100960111
115 rdf:type schema:PropertyValue
116 N864543acf46e412abd2d6c784331e8de schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N86cc12e94d094d9197b796cc3e33e9e1 rdf:first N31363375024a43199b84d0eabf4a63b7
119 rdf:rest N89c35fde701a4a779df79eaddec08081
120 N86d8140e65e7407b8e6182d7dcc24640 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
121 schema:familyName Yu
122 schema:givenName Jiangnan
123 rdf:type schema:Person
124 N89c35fde701a4a779df79eaddec08081 rdf:first N86d8140e65e7407b8e6182d7dcc24640
125 rdf:rest N3e809b63a7a14ee1b5df086e0b28beb9
126 Na653db0120bb43c3abeda91eac9d3090 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
127 schema:familyName Zhu
128 schema:givenName Yuan
129 rdf:type schema:Person
130 Nb39262cc05e1425ab6e3ceeb1b5ab7fb schema:issueNumber 4
131 rdf:type schema:PublicationIssue
132 Nb5da24a111224fe3ab0c0b969679d477 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
133 schema:familyName Xu
134 schema:givenName Wen
135 rdf:type schema:Person
136 Nd1fed8b369f54b21b94cc29b4aa69dc5 rdf:first N11a7cf0473ff42c895ea58685f2afafa
137 rdf:rest N2ea1eb9ea19a4871b42095b6f0a7a30c
138 Nd364cb8a00494eddb44d2b4d0f693e28 schema:name readcube_id
139 schema:value 97e40ecc726ed7d9c930a948b1097179d4d714c5b9e2d7588bd6558de0be3710
140 rdf:type schema:PropertyValue
141 Ndcc5f8dd79b84d51b52680dfcc2f0250 rdf:first N5985f16c0ddc45d982e2bd10e8fb30c8
142 rdf:rest N07268ad916bf4f9d9615893adde99d4d
143 Ne6f491dcafe5497f93dbfcf3339efc98 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
144 schema:familyName Zhang
145 schema:givenName Jiajia
146 rdf:type schema:Person
147 Nf7d9663c44bb4fe2a8e45c77677880f0 schema:affiliation https://www.grid.ac/institutes/grid.440785.a
148 schema:familyName Firempong
149 schema:givenName Caleb Kesse
150 rdf:type schema:Person
151 Nfb32937a9a684b468506be94a58bc922 schema:volumeNumber 20
152 rdf:type schema:PublicationVolume
153 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
154 schema:name Technology
155 rdf:type schema:DefinedTerm
156 anzsrc-for:1007 schema:inDefinedTermSet anzsrc-for:
157 schema:name Nanotechnology
158 rdf:type schema:DefinedTerm
159 sg:journal.1023420 schema:issn 1530-9932
160 schema:name AAPS PharmSciTech
161 rdf:type schema:Periodical
162 sg:pub.10.1007/bf01061761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036555799
163 https://doi.org/10.1007/bf01061761
164 rdf:type schema:CreativeWork
165 sg:pub.10.1007/s11095-013-1063-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1010118445
166 https://doi.org/10.1007/s11095-013-1063-y
167 rdf:type schema:CreativeWork
168 sg:pub.10.1208/s12249-009-9281-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050183488
169 https://doi.org/10.1208/s12249-009-9281-7
170 rdf:type schema:CreativeWork
171 sg:pub.10.1208/s12249-010-9385-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011618445
172 https://doi.org/10.1208/s12249-010-9385-0
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/jsfa.7002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034397155
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0169-409x(92)90015-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1031065926
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.biopha.2004.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012015777
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.cbi.2009.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016088198
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.colsurfa.2011.09.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008203131
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.ejpb.2011.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022349032
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.ejpb.2012.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011677836
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.ejps.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026387460
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.ejps.2013.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042526720
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.ejps.2018.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110267283
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.fitote.2012.08.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010168690
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.foodhyd.2015.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013685956
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.foodhyd.2018.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104125997
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.ijpharm.2007.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019276053
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.ijpharm.2008.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035544408
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.ijpharm.2009.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037573118
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.ijpharm.2011.04.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041342637
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ijpharm.2011.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035540857
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ijpharm.2012.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014652357
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.ijpharm.2013.05.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044703662
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.ijpharm.2013.10.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002888066
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.ijpharm.2016.04.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044654747
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.intimp.2014.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038224421
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.jff.2012.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009686904
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.jff.2013.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042953470
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.jff.2014.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002648334
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jff.2014.12.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030845022
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.kjms.2016.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046271155
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.nano.2013.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023221752
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.pbb.2012.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020045849
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.phymed.2018.09.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106577737
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.seppur.2014.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020359218
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.ultsonch.2013.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052364649
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0731-7085(97)00243-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046503579
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1021/js9700863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026640216
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1111/j.1600-0536.1999.tb06009.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011932372
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1111/j.2042-7158.2010.01149.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042864415
247 rdf:type schema:CreativeWork
248 https://doi.org/10.2147/ijn.s83520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013177979
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3109/03639049709150551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007277854
251 rdf:type schema:CreativeWork
252 https://www.grid.ac/institutes/grid.440785.a schema:alternateName Jiangsu University
253 schema:name Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, 212013, Zhenjiang, People’s Republic of China
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...