Co-delivery of Doxorubicin and Ceramide in a Liposomal Formulation Enhances Cytotoxicity in Murine B16BL6 Melanoma Cell Lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Li Chen, Hamad Alrbyawi, Ishwor Poudel, Robert D. Arnold, R. Jayachandra Babu

ABSTRACT

This study reports co-delivery of doxorubicin (DOX) and ceramide in a liposomal system in B16BL6 melanoma cell lines for enhanced cytotoxic effects. Different types of ceramides (C6-ceramide, C8-ceramide, and C8-glucosylceramide) and lipids (1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)) were considered in the preparation of liposomes. DOX was encapsulated within liposome, and ceramide was used as the component of the lipid bilayer. The formulations were optimized for size and size distribution, zeta potential, and DOX encapsulation efficiency (EE). Cytotoxic effect on B16BL6 melanoma cell lines was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The ceramide based liposome formulations generally provided a mean diameter < 181 nm, a zeta potential, + 35 mV, and EE > 90% DOX EE. Co-delivery of DOX and C8-ceramide with DOTAP liposomes demonstrated significantly higher cytotoxicity as compared to DOX liposomes without ceramide (P < 0.001), and also showed enhanced cellular uptake by B16BL6 cell lines. This study provides basis for developing a co-delivery system of DOX and ceramide for lowering the dose and dose-related side effects of DOX for the treatment of melanoma. More... »

PAGES

99

References to SciGraph publications

  • 2014-08. Electrochemotherapy for the management of melanoma skin metastasis: a review of the literature and possible combinations with immunotherapy in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 2017-05. Formulation and Optimization of Doxorubicin and Biochanin A Combinational Liposomes for Reversal of Chemoresistance in AAPS PHARMSCITECH
  • 2014-06. What Is the Role of Chemotherapy in the Treatment of Melanoma? in CURRENT TREATMENT OPTIONS IN ONCOLOGY
  • 2004-02. Melanoma Diagnosis by Raman Spectroscopy and Neural Networks: Structure Alterations in Proteins and Lipids in Intact Cancer Tissue in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2013-11. Bioactive Lipids-Based pH Sensitive Micelles for Co-Delivery of Doxorubicin and Ceramide to Overcome Multidrug Resistance in Leukemia in PHARMACEUTICAL RESEARCH
  • 2015-05. Down-regulation of MFG-E8 by RNA interference combined with doxorubicin triggers melanoma destruction in CLINICAL AND EXPERIMENTAL MEDICINE
  • 2012-01. Factors affecting the pharmacokinetics of pegylated liposomal doxorubicin in patients in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-03. Endogenous sphingolipid metabolites related to the growth inSphingomonas chungbukensis in ARCHIVES OF PHARMACAL RESEARCH
  • 2014-01. Pegylated liposomal doxorubicin and renal thrombotic microangiopathy: an under-recognized complication of prolonged treatment for ovarian cancer in KIDNEY INTERNATIONAL
  • 2007-02. Melanoma biology and new targeted therapy in NATURE
  • 2016-12. A Novel Folate-Targeted Nanoliposomal System of Doxorubicin for Cancer Targeting in AAPS PHARMSCITECH
  • 2014-09. Liposomal anthracycline chemotherapy and the risk of second malignancies in patients with Kaposi’s sarcoma (KS) in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2016-11. Nanomedicines: From Bench to Bedside and Beyond in THE AAPS JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1208/s12249-019-1316-0

    DOI

    http://dx.doi.org/10.1208/s12249-019-1316-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111916374

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30719596


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