Design and Development of Lidocaine Microemulsions for Transdermal Delivery View Full Text


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Article Info

DATE

2019-01-09

AUTHORS

Yaping Wang, Xihui Wang, Xiangyu Wang, Yilei Song, Xiaodan Wang, Jifu Hao

ABSTRACT

Topical administration is a preferable choice for local anesthetic delivery. Microemulsions have shown great effectiveness for transdermal transport of lidocaine. However, fabrication of microemulsions containing highly concentrated lidocaine (10%) to provide an extended local anesthetic effect is still a challenge. This study investigated the feasibility of using microemulsions for transdermal delivery of a high dosage of lidocaine (10%). At first, eutectic mixtures by kneading lidocaine with thymol were tailored to form a lipophilic solution, then the mixtures were readily incorporated into the oil phase of microemulsions after addition of proper surfactants and cosurfactants. The physicochemical properties, the skin permeation, local anesthetic efficacy, and the irritation experiment of the developed microemulsions were evaluated. The optimum composition was as follows: 12% of ethyl oleate as oil phase, 28% of the mixed surfactant, and cosurfactant (polyoxyl 15 hydroxystearate and ethanol) and 60% of the aqueous phase. The average particle size was about 13 nm. The transmission electron microscope (TEM) studies revealed almost homogeneous spherical globules without aggregation. The Fourier-transform infrared spectroscopy (FTIR) results highlighted the drugs homogeneously dispersed in the microemulsions. In vitro skin permeation and in vivo anesthesia effect evaluation indicated that microemulsions can enhance and extend the anesthetic effect of lidocaine. The irritable results indicated that the microemulsions had the better biocompatibility and the negligible influence on the dermal. Therefore, incorporating the eutectic mixtures into microemulsions could be proposed as an attractive choice and a promising transdermal delivery strategy for the future topical anesthetic therapy. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1208/s12249-018-1263-1

DOI

http://dx.doi.org/10.1208/s12249-018-1263-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111310856

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30627930


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