DEM Modelling of Granule Rearrangement and Fracture Behaviours During a Closed-Die Compaction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Ryoichi Furukawa, Kazunori Kadota, Tetsuro Noguchi, Atsuko Shimosaka, Yoshiyuki Shirakawa

ABSTRACT

The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglomerates of primary particles connected by linear spring bonds. The validity of the model granule used in the DEM simulation was demonstrated by comparing to the experimental results of a uniaxial compression test. During uniaxial compression, the numerical results of the force-displacement curve corresponded reasonably well to the experimental data. The closed-die compaction of the modelled granules was carried out to investigate the rearrangement and fracture behaviours of the granule at different upper platen velocities. The forces during closed-die compaction calculated by DEM fluctuated in the low-pressure region due to the rearrangement of granules. A Heckel analysis showed that the force fluctuation occurred at the initial bending region of the Heckel plot, which represents the granule rearrangement and fracture. Furthermore, the upper platen velocity affected the trend of compaction forces, which can lead to compaction failure due to capping. These results could contribute to designing the appropriate granules during closed-die compaction. More... »

PAGES

2368-2377

Identifiers

URI

http://scigraph.springernature.com/pub.10.1208/s12249-017-0719-z

DOI

http://dx.doi.org/10.1208/s12249-017-0719-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1074223555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28127720


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0905", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Civil Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mannitol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tablets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Technology, Pharmaceutical", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Doshisha University", 
          "id": "https://www.grid.ac/institutes/grid.255178.c", 
          "name": [
            "Pharmaceutical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, 532-8505, Osaka, Yodogawa-ku, Japan", 
            "Department of Chemical Engineering and Materials Science, Doshisha University, 1-3, Tatara Miyakodani, 610-0321, Kyotanabe, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furukawa", 
        "givenName": "Ryoichi", 
        "id": "sg:person.014760205745.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014760205745.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka University of Pharmaceutical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.444888.c", 
          "name": [
            "Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, 569-1094, Osaka, Takatsuki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kadota", 
        "givenName": "Kazunori", 
        "id": "sg:person.01303400522.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303400522.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsubishi Chemical Holdings (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.418306.8", 
          "name": [
            "Pharmaceutical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, 532-8505, Osaka, Yodogawa-ku, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noguchi", 
        "givenName": "Tetsuro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Doshisha University", 
          "id": "https://www.grid.ac/institutes/grid.255178.c", 
          "name": [
            "Department of Chemical Engineering and Materials Science, Doshisha University, 1-3, Tatara Miyakodani, 610-0321, Kyotanabe, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimosaka", 
        "givenName": "Atsuko", 
        "id": "sg:person.016537123310.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537123310.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Doshisha University", 
          "id": "https://www.grid.ac/institutes/grid.255178.c", 
          "name": [
            "Department of Chemical Engineering and Materials Science, Doshisha University, 1-3, Tatara Miyakodani, 610-0321, Kyotanabe, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirakawa", 
        "givenName": "Yoshiyuki", 
        "id": "sg:person.07632435601.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07632435601.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2015.07.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000865964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(03)00093-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(03)00093-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(99)00120-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001385452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03639049009114881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004085395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2004.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006328240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2004.02.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007344110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cite.330300307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008293212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2011.12.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008558253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aic.14572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008934681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.20262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010342184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2011.10.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011443552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ces.2005.02.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013616082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.partic.2012.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014411324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2011.03.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014459891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(02)00256-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017387038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(02)00256-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017387038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0032-5910(71)80001-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017857383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(02)00238-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019740030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2008.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021951534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0032-5910(91)80189-p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023069606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10035-009-0161-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031333712", 
          "https://doi.org/10.1007/s10035-009-0161-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10035-009-0161-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031333712", 
          "https://doi.org/10.1007/s10035-009-0161-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2010.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032851933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ces.2005.02.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033034933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2014.03.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034098620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/aic.690460312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034510193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03639049209058560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035024450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2010.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036389473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2013.01.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037034345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2007.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039310720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2004.04.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040985739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actamat.2009.09.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042322524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(99)00231-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045117445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(99)00119-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046518503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1551-2916.2006.01249.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046921703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jps.21488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046928759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2004.01.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048154527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1208/s12249-011-9623-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049241871", 
          "https://doi.org/10.1208/s12249-011-9623-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2008.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049513131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2010.02.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049687419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.powtec.2004.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049731592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0032-5910(01)00313-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050345954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(91)90049-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051540404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(91)90049-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051540404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cep.2005.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053703441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1680/geot.1979.29.1.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068209785"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08", 
    "datePublishedReg": "2017-08-01", 
    "description": "The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglomerates of primary particles connected by linear spring bonds. The validity of the model granule used in the DEM simulation was demonstrated by comparing to the experimental results of a uniaxial compression test. During uniaxial compression, the numerical results of the force-displacement curve corresponded reasonably well to the experimental data. The closed-die compaction of the modelled granules was carried out to investigate the rearrangement and fracture behaviours of the granule at different upper platen velocities. The forces during closed-die compaction calculated by DEM fluctuated in the low-pressure region due to the rearrangement of granules. A Heckel analysis showed that the force fluctuation occurred at the initial bending region of the Heckel plot, which represents the granule rearrangement and fracture. Furthermore, the upper platen velocity affected the trend of compaction forces, which can lead to compaction failure due to capping. These results could contribute to designing the appropriate granules during closed-die compaction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1208/s12249-017-0719-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1023420", 
        "issn": [
          "1530-9932"
        ], 
        "name": "AAPS PharmSciTech", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "DEM Modelling of Granule Rearrangement and Fracture Behaviours During a Closed-Die Compaction", 
    "pagination": "2368-2377", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6593b7d4848f4c6e92beda202fb4802a9af0ae7781c9ec122a4457b355bdedec"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28127720"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100960111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1208/s12249-017-0719-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1074223555"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1208/s12249-017-0719-z", 
      "https://app.dimensions.ai/details/publication/pub.1074223555"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89789_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1208%2Fs12249-017-0719-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1208/s12249-017-0719-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1208/s12249-017-0719-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1208/s12249-017-0719-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1208/s12249-017-0719-z'


 

This table displays all metadata directly associated to this object as RDF triples.

249 TRIPLES      21 PREDICATES      76 URIs      25 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1208/s12249-017-0719-z schema:about N0d2f90e4a92241fc960a706996a624cb
2 N9a1ad59ffee64784947b88b43da4999b
3 Na292f58af1c14893b1c85c4a5ab78245
4 Ne67bcee0c75d4df199ebb0a24530a09a
5 anzsrc-for:09
6 anzsrc-for:0905
7 schema:author N4f4793d4b98542cf97b1ae6d201d76ad
8 schema:citation sg:pub.10.1007/s10035-009-0161-3
9 sg:pub.10.1208/s12249-011-9623-0
10 https://doi.org/10.1002/aic.14572
11 https://doi.org/10.1002/aic.690460312
12 https://doi.org/10.1002/cite.330300307
13 https://doi.org/10.1002/jps.20262
14 https://doi.org/10.1002/jps.21488
15 https://doi.org/10.1016/0032-5910(71)80001-3
16 https://doi.org/10.1016/0032-5910(91)80189-p
17 https://doi.org/10.1016/0378-5173(91)90049-t
18 https://doi.org/10.1016/j.actamat.2009.09.058
19 https://doi.org/10.1016/j.cep.2005.12.005
20 https://doi.org/10.1016/j.ces.2005.02.036
21 https://doi.org/10.1016/j.ces.2005.02.038
22 https://doi.org/10.1016/j.ejpb.2008.09.014
23 https://doi.org/10.1016/j.ejpb.2010.04.006
24 https://doi.org/10.1016/j.ijpharm.2015.07.029
25 https://doi.org/10.1016/j.partic.2012.04.002
26 https://doi.org/10.1016/j.powtec.2004.01.016
27 https://doi.org/10.1016/j.powtec.2004.01.022
28 https://doi.org/10.1016/j.powtec.2004.02.010
29 https://doi.org/10.1016/j.powtec.2004.04.032
30 https://doi.org/10.1016/j.powtec.2004.11.024
31 https://doi.org/10.1016/j.powtec.2007.08.010
32 https://doi.org/10.1016/j.powtec.2008.05.016
33 https://doi.org/10.1016/j.powtec.2010.02.025
34 https://doi.org/10.1016/j.powtec.2010.06.002
35 https://doi.org/10.1016/j.powtec.2011.03.023
36 https://doi.org/10.1016/j.powtec.2011.10.042
37 https://doi.org/10.1016/j.powtec.2011.12.054
38 https://doi.org/10.1016/j.powtec.2013.01.023
39 https://doi.org/10.1016/j.powtec.2014.03.042
40 https://doi.org/10.1016/s0032-5910(01)00313-8
41 https://doi.org/10.1016/s0032-5910(02)00238-3
42 https://doi.org/10.1016/s0032-5910(02)00256-5
43 https://doi.org/10.1016/s0032-5910(03)00093-7
44 https://doi.org/10.1016/s0032-5910(99)00119-9
45 https://doi.org/10.1016/s0032-5910(99)00120-5
46 https://doi.org/10.1016/s0032-5910(99)00231-4
47 https://doi.org/10.1111/j.1551-2916.2006.01249.x
48 https://doi.org/10.1680/geot.1979.29.1.47
49 https://doi.org/10.3109/03639049009114881
50 https://doi.org/10.3109/03639049209058560
51 schema:datePublished 2017-08
52 schema:datePublishedReg 2017-08-01
53 schema:description The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglomerates of primary particles connected by linear spring bonds. The validity of the model granule used in the DEM simulation was demonstrated by comparing to the experimental results of a uniaxial compression test. During uniaxial compression, the numerical results of the force-displacement curve corresponded reasonably well to the experimental data. The closed-die compaction of the modelled granules was carried out to investigate the rearrangement and fracture behaviours of the granule at different upper platen velocities. The forces during closed-die compaction calculated by DEM fluctuated in the low-pressure region due to the rearrangement of granules. A Heckel analysis showed that the force fluctuation occurred at the initial bending region of the Heckel plot, which represents the granule rearrangement and fracture. Furthermore, the upper platen velocity affected the trend of compaction forces, which can lead to compaction failure due to capping. These results could contribute to designing the appropriate granules during closed-die compaction.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree false
57 schema:isPartOf N03ff471b7218488f91afc5f00dbc2197
58 Neca57fc43fa449b6939340f980ec6a7a
59 sg:journal.1023420
60 schema:name DEM Modelling of Granule Rearrangement and Fracture Behaviours During a Closed-Die Compaction
61 schema:pagination 2368-2377
62 schema:productId N795a658664a0441098a0270fa02b1dba
63 Na10243ddfa5447058f65fe4c2701e937
64 Nb16e1e491a464858933dfde9b9f809fd
65 Nbb56e684104a44a3b7bdee1e38d3c16f
66 Nc7a4901768a447e0b901920bd1abc1b3
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074223555
68 https://doi.org/10.1208/s12249-017-0719-z
69 schema:sdDatePublished 2019-04-11T09:51
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N532f353cbe3d4a9b8f8e22625b96be1e
72 schema:url https://link.springer.com/10.1208%2Fs12249-017-0719-z
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N03ff471b7218488f91afc5f00dbc2197 schema:issueNumber 6
77 rdf:type schema:PublicationIssue
78 N0d2f90e4a92241fc960a706996a624cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Tablets
80 rdf:type schema:DefinedTerm
81 N2e8d5e8e62a04000bb8a8b57d4fa96ca rdf:first sg:person.07632435601.33
82 rdf:rest rdf:nil
83 N45de7e01417840f691f2a6595d1f5019 rdf:first sg:person.01303400522.12
84 rdf:rest Nbf7cfbc92469464c9ce99ddabbf87a98
85 N4f4793d4b98542cf97b1ae6d201d76ad rdf:first sg:person.014760205745.46
86 rdf:rest N45de7e01417840f691f2a6595d1f5019
87 N532f353cbe3d4a9b8f8e22625b96be1e schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N6a7499463a404c02adc04915e9a7f044 schema:affiliation https://www.grid.ac/institutes/grid.418306.8
90 schema:familyName Noguchi
91 schema:givenName Tetsuro
92 rdf:type schema:Person
93 N795a658664a0441098a0270fa02b1dba schema:name doi
94 schema:value 10.1208/s12249-017-0719-z
95 rdf:type schema:PropertyValue
96 N9a1ad59ffee64784947b88b43da4999b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Mannitol
98 rdf:type schema:DefinedTerm
99 Na10243ddfa5447058f65fe4c2701e937 schema:name readcube_id
100 schema:value 6593b7d4848f4c6e92beda202fb4802a9af0ae7781c9ec122a4457b355bdedec
101 rdf:type schema:PropertyValue
102 Na292f58af1c14893b1c85c4a5ab78245 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Technology, Pharmaceutical
104 rdf:type schema:DefinedTerm
105 Nb16e1e491a464858933dfde9b9f809fd schema:name pubmed_id
106 schema:value 28127720
107 rdf:type schema:PropertyValue
108 Nb2b0c9e2986a42c5b8a494dd251818a2 rdf:first sg:person.016537123310.68
109 rdf:rest N2e8d5e8e62a04000bb8a8b57d4fa96ca
110 Nbb56e684104a44a3b7bdee1e38d3c16f schema:name nlm_unique_id
111 schema:value 100960111
112 rdf:type schema:PropertyValue
113 Nbf7cfbc92469464c9ce99ddabbf87a98 rdf:first N6a7499463a404c02adc04915e9a7f044
114 rdf:rest Nb2b0c9e2986a42c5b8a494dd251818a2
115 Nc7a4901768a447e0b901920bd1abc1b3 schema:name dimensions_id
116 schema:value pub.1074223555
117 rdf:type schema:PropertyValue
118 Ne67bcee0c75d4df199ebb0a24530a09a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Pressure
120 rdf:type schema:DefinedTerm
121 Neca57fc43fa449b6939340f980ec6a7a schema:volumeNumber 18
122 rdf:type schema:PublicationVolume
123 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
124 schema:name Engineering
125 rdf:type schema:DefinedTerm
126 anzsrc-for:0905 schema:inDefinedTermSet anzsrc-for:
127 schema:name Civil Engineering
128 rdf:type schema:DefinedTerm
129 sg:journal.1023420 schema:issn 1530-9932
130 schema:name AAPS PharmSciTech
131 rdf:type schema:Periodical
132 sg:person.01303400522.12 schema:affiliation https://www.grid.ac/institutes/grid.444888.c
133 schema:familyName Kadota
134 schema:givenName Kazunori
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303400522.12
136 rdf:type schema:Person
137 sg:person.014760205745.46 schema:affiliation https://www.grid.ac/institutes/grid.255178.c
138 schema:familyName Furukawa
139 schema:givenName Ryoichi
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014760205745.46
141 rdf:type schema:Person
142 sg:person.016537123310.68 schema:affiliation https://www.grid.ac/institutes/grid.255178.c
143 schema:familyName Shimosaka
144 schema:givenName Atsuko
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016537123310.68
146 rdf:type schema:Person
147 sg:person.07632435601.33 schema:affiliation https://www.grid.ac/institutes/grid.255178.c
148 schema:familyName Shirakawa
149 schema:givenName Yoshiyuki
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07632435601.33
151 rdf:type schema:Person
152 sg:pub.10.1007/s10035-009-0161-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031333712
153 https://doi.org/10.1007/s10035-009-0161-3
154 rdf:type schema:CreativeWork
155 sg:pub.10.1208/s12249-011-9623-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049241871
156 https://doi.org/10.1208/s12249-011-9623-0
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1002/aic.14572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008934681
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1002/aic.690460312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034510193
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1002/cite.330300307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008293212
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/jps.20262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010342184
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/jps.21488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046928759
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/0032-5910(71)80001-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017857383
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/0032-5910(91)80189-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1023069606
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/0378-5173(91)90049-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1051540404
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.actamat.2009.09.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042322524
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.cep.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053703441
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.ces.2005.02.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013616082
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.ces.2005.02.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033034933
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.ejpb.2008.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049513131
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.ejpb.2010.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032851933
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.ijpharm.2015.07.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000865964
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.partic.2012.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014411324
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.powtec.2004.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049731592
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.powtec.2004.01.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048154527
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.powtec.2004.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007344110
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.powtec.2004.04.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040985739
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.powtec.2004.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006328240
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.powtec.2007.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039310720
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.powtec.2008.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021951534
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.powtec.2010.02.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049687419
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.powtec.2010.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036389473
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.powtec.2011.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014459891
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.powtec.2011.10.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011443552
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.powtec.2011.12.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008558253
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.powtec.2013.01.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037034345
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.powtec.2014.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034098620
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0032-5910(01)00313-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050345954
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0032-5910(02)00238-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019740030
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0032-5910(02)00256-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017387038
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0032-5910(03)00093-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929290
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0032-5910(99)00119-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046518503
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0032-5910(99)00120-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001385452
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0032-5910(99)00231-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045117445
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1111/j.1551-2916.2006.01249.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046921703
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1680/geot.1979.29.1.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068209785
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3109/03639049009114881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004085395
237 rdf:type schema:CreativeWork
238 https://doi.org/10.3109/03639049209058560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035024450
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.255178.c schema:alternateName Doshisha University
241 schema:name Department of Chemical Engineering and Materials Science, Doshisha University, 1-3, Tatara Miyakodani, 610-0321, Kyotanabe, Kyoto, Japan
242 Pharmaceutical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, 532-8505, Osaka, Yodogawa-ku, Japan
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.418306.8 schema:alternateName Mitsubishi Chemical Holdings (Japan)
245 schema:name Pharmaceutical Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3-16-89, Kashima, 532-8505, Osaka, Yodogawa-ku, Japan
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.444888.c schema:alternateName Osaka University of Pharmaceutical Sciences
248 schema:name Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, 569-1094, Osaka, Takatsuki, Japan
249 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...