Ontology type: schema:ScholarlyArticle
2017-08
AUTHORSAhmed A. El-Shenawy, Mahmoud M. Ahmed, Heba F. Mansour, Saleh Abd El Rasoul
ABSTRACTThe present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD was selected for formulation of torsemide FDTs by direct compression method. Box-Bhenken factorial design was employed to design 15 formulations using croscarmellose sodium and crospovidone at different concentrations. The response surface methodology was used to analyze the effect of changing these concentrations (independent variables) on disintegration time (Y1), percentage friability (Y2), and amount torsemide released at 10 min. The physical mixtures of torsemide and the used excipients were evaluated for angle of repose, Hausner's ratio, and Carr's index. The prepared FDTs tablets were evaluated for wetting and disintegration time, weight variation, drug content, percentage friability, thickness, hardness, and in vitro release. Based on the in-vitro results and factorial design characterization, F10 and F7 were selected for bioavailability studies following administration to Albino New Zealand rabbits. They showed significantly higher C max and (AUC0-12) and shorter T max than those obtained after administration of the corresponding ordinary commercial Torseretic ® tablets. Stability study was conducted for F10 that showed good stability upon storage at 30°C/75% RH and 40°C/75% RH for 3 months. More... »
PAGES2168-2179
http://scigraph.springernature.com/pub.10.1208/s12249-016-0697-6
DOIhttp://dx.doi.org/10.1208/s12249-016-0697-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1001551151
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28050711
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Chemistry (incl. Structural)",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Chemical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antihypertensive Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biological Availability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Calorimetry, Differential Scanning",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carboxymethylcellulose Sodium",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Compounding",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Excipients",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Pharmaceutic Aids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Povidone",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rabbits",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Solubility",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sorbitol",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Spectroscopy, Fourier Transform Infrared",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sulfonamides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sweetening Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tablets",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Torsemide",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Al Azhar University",
"id": "https://www.grid.ac/institutes/grid.411303.4",
"name": [
"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt"
],
"type": "Organization"
},
"familyName": "El-Shenawy",
"givenName": "Ahmed A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Sohag University",
"id": "https://www.grid.ac/institutes/grid.412659.d",
"name": [
"Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Egypt"
],
"type": "Organization"
},
"familyName": "Ahmed",
"givenName": "Mahmoud M.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Minia University",
"id": "https://www.grid.ac/institutes/grid.411806.a",
"name": [
"Department of Pharmaceutics, Faculty of Pharmacy, Minia University, P.O.Box 61111, Minia, Egypt"
],
"type": "Organization"
},
"familyName": "Mansour",
"givenName": "Heba F.",
"id": "sg:person.014521170355.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014521170355.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Al Azhar University",
"id": "https://www.grid.ac/institutes/grid.411303.4",
"name": [
"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt"
],
"type": "Organization"
},
"familyName": "Abd El Rasoul",
"givenName": "Saleh",
"id": "sg:person.016007601766.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016007601766.82"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1208/s12249-009-9237-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000315201",
"https://doi.org/10.1208/s12249-009-9237-y"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10837450.2012.710238",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001756070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4314/tjpr.v9i5.61063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003251948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4314/tjpr.v9i5.61063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003251948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/03639045.2015.1018274",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004683007"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/03639040701377888",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004940265"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-008-9784-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005489333",
"https://doi.org/10.1007/s11095-008-9784-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.addr.2007.05.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008039331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0939-6411(00)00076-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010715816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.21163",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010819060"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1011976615750",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013130879",
"https://doi.org/10.1023/a:1011976615750"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.24410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017126325"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1208/pt060479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019722358",
"https://doi.org/10.1208/pt060479"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9343(01)00903-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023880052"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijpharm.2004.08.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024834659"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.aca.2007.07.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031376299"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejpb.2006.08.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034710156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1248/cpb.54.1072",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037498189"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10837450.2013.813543",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038059336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0378-5173(01)00891-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039124967"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jps.23539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039258726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4172/2329-9053.1000r1-001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046751510"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-006-9063-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048235358",
"https://doi.org/10.1007/s11095-006-9063-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-008-9721-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051503582",
"https://doi.org/10.1007/s11095-008-9721-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/mp1003674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056212476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/mp1003674",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056212476"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079798664",
"type": "CreativeWork"
}
],
"datePublished": "2017-08",
"datePublishedReg": "2017-08-01",
"description": "The present study planed to develop new fast dissolving tablets (FDTs) of torsemide. Solid dispersions (SDs) of torsemide and sorbitol (3:1) or polyvinylpyrrolidone (PVP) k25 were prepared. The prepared SDs were evaluated for in-vitro dissolution. Fourier transform infrared spectroscopy and differential scanning calorimetry for SDs revealed no drug/excipient interactions and transformation of torsemide to the amorphous form. Torsemide/sorbitol SD was selected for formulation of torsemide FDTs by direct compression method. Box-Bhenken factorial design was employed to design 15 formulations using croscarmellose sodium and crospovidone at different concentrations. The response surface methodology was used to analyze the effect of changing these concentrations (independent variables) on disintegration time (Y1), percentage friability (Y2), and amount torsemide released at 10\u00a0min. The physical mixtures of torsemide and the used excipients were evaluated for angle of repose, Hausner's ratio, and Carr's index. The prepared FDTs tablets were evaluated for wetting and disintegration time, weight variation, drug content, percentage friability, thickness, hardness, and in vitro release. Based on the in-vitro results and factorial design characterization, F10 and F7 were selected for bioavailability studies following administration to Albino New Zealand rabbits. They showed significantly higher C max and (AUC0-12) and shorter T max than those obtained after administration of the corresponding ordinary commercial Torseretic \u00ae tablets. Stability study was conducted for F10 that showed good stability upon storage at 30\u00b0C/75% RH and 40\u00b0C/75% RH for 3\u00a0months.",
"genre": "research_article",
"id": "sg:pub.10.1208/s12249-016-0697-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1023420",
"issn": [
"1530-9932"
],
"name": "AAPS PharmSciTech",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "18"
}
],
"name": "Torsemide Fast Dissolving Tablets: Development, Optimization Using Box\u2013Bhenken Design and Response Surface Methodology, In Vitro Characterization, and Pharmacokinetic Assessment",
"pagination": "2168-2179",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"07636907b0513f2a3905372c1f725291b29655612b47b7a8c64bb7470b98b3e4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28050711"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100960111"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1208/s12249-016-0697-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1001551151"
]
}
],
"sameAs": [
"https://doi.org/10.1208/s12249-016-0697-6",
"https://app.dimensions.ai/details/publication/pub.1001551151"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89812_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1208%2Fs12249-016-0697-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1208/s12249-016-0697-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1208/s12249-016-0697-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1208/s12249-016-0697-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1208/s12249-016-0697-6'
This table displays all metadata directly associated to this object as RDF triples.
241 TRIPLES
21 PREDICATES
71 URIs
38 LITERALS
26 BLANK NODES