A Novel Intestine Model Apparatus for Drug Dissolution Capable of Simulating the Peristaltic Action View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

Melita Hribar, Jurij Trontelj, Uroš Klančar, Boštjan Markun, Tanja Čeligoj Dujc, Igor Legen

ABSTRACT

A novel dissolution apparatus has been proposed as an alternative apparatus for dissolution testing. In this study, we evaluated the performance of the new intestine model for simulating the peristaltic action (IMSPA), generating the movement that closely mimics peristaltic contractions of the small intestine. Two polyethylene oxide matrix tablet formulations, containing a model drug belonging to class III of the Biopharmaceutics Classification System, were tested. Dissolution was also performed in the USP2 apparatus. The release profiles were further compared to the in vivo data to evaluate the in vivo relevance of the new apparatus. The results demonstrated that the novel apparatus showed good discriminatory power between different polyethylene oxide formulations. Moreover, a better relation to the in vivo data was established by the IMSPA as compared to the USP2 apparatus. In conclusion, the model parameters were efficiently controlled to ensure the dissolution conditions crucial for evaluating the in vivo release performance of the tested formulations. More... »

PAGES

1646-1656

Identifiers

URI

http://scigraph.springernature.com/pub.10.1208/s12249-016-0629-5

DOI

http://dx.doi.org/10.1208/s12249-016-0629-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016764710

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27663704


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