The crystal structure and physicochemical characteristics of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine, a new antitrypanosomal compound View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-12-27

AUTHORS

Norma R. Sperandeo, Alicia Karlsson, Silvia Cuffini, Silvina Pagola, Peter W. Stephens

ABSTRACT

This study was designed to investigate the physical characteristics and crystalline structure of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine (PNQ), a new active compound againstTrypanosoma cruzi, the causative agent of American trypanosomiasis. Methods used included differential scanning calorimetry, thermogravimetry, hot stage microscopy, polarized light microscopy (PLM), Fourier-transform infrared (FTIR) spectroscopy, and high-resolution X-ray powder diffraction (HR-XRPD). According to PLM and HR-XRPD data, PNQ crystallized as red oolitic crystals (absolute methanol) or prisms (dimethyl sulfoxide [DMSO]-water) with the same internal structure. The findings obtained with HR-XRPD data (applying molecular location methods) showed a monoclinic unit cell [a=18.4437(1)Å, b=3.9968(2) Å, c=14.5304(1) Å, α=90°, β=102.71(6)°, γ=90°, V=1044.9(1) Å3, Z=4, space group P21/c], and a crystal structure (excluding H-positions) described by parallel layers in the direction of theb-axis, with molecules held by homochemical (phenyl-phenyl and pyrazole-pyrazole) van der Waals interactions. In addition, FTIR spectra displayed the NH-pyrazole stretch overlapped with the OH absorption at 3222 cm−1, typical of-NH and-OH groups associated through H-bondings; and a carbonyl stretching absorption at 1694 cm−1, indicating a non-extensively H-bonded quinonic C=O, which was in accordance with the solved crystal structure of PNQ. The existence of such cohesive forces shed light on the thermo-analytical data, which revealed that PNQ is a stable solid, unaffected by oxygen that decomposed without melting above 260°C. More... »

PAGES

e655-e663

Identifiers

URI

http://scigraph.springernature.com/pub.10.1208/pt060482

DOI

http://dx.doi.org/10.1208/pt060482

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022919464

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16408868


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antiprotozoal Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemical Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemistry, Physical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crystallization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Naphthoquinones", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departamento de Farmacia, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, 5000, C\u00f3rdoba, Argentina", 
          "id": "http://www.grid.ac/institutes/grid.10692.3c", 
          "name": [
            "Departamento de Farmacia, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, 5000, C\u00f3rdoba, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sperandeo", 
        "givenName": "Norma R.", 
        "id": "sg:person.01251266624.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251266624.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "C\u00e1tedra de M\u00e9todos de Investigaci\u00f3n de Minerales, Facultad Ciencias Exactas, F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina", 
          "id": "http://www.grid.ac/institutes/grid.10692.3c", 
          "name": [
            "C\u00e1tedra de M\u00e9todos de Investigaci\u00f3n de Minerales, Facultad Ciencias Exactas, F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karlsson", 
        "givenName": "Alicia", 
        "id": "sg:person.0675413661.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675413661.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agencia C\u00f3rdoba Ciencia, CEPROCOR, C\u00f3rdoba, Argentina", 
          "id": "http://www.grid.ac/institutes/grid.473248.e", 
          "name": [
            "Agencia C\u00f3rdoba Ciencia, CEPROCOR, C\u00f3rdoba, Argentina"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cuffini", 
        "givenName": "Silvia", 
        "id": "sg:person.0751340267.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751340267.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pagola", 
        "givenName": "Silvina", 
        "id": "sg:person.011406475413.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406475413.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY", 
          "id": "http://www.grid.ac/institutes/grid.36425.36", 
          "name": [
            "Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stephens", 
        "givenName": "Peter W.", 
        "id": "sg:person.01036212433.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036212433.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02549315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034615055", 
          "https://doi.org/10.1007/bf02549315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35005132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025974202", 
          "https://doi.org/10.1038/35005132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018832526093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042276013", 
          "https://doi.org/10.1023/a:1018832526093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1016212804288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037126380", 
          "https://doi.org/10.1023/a:1016212804288"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-12-27", 
    "datePublishedReg": "2005-12-27", 
    "description": "This study was designed to investigate the physical characteristics and crystalline structure of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine (PNQ), a new active compound againstTrypanosoma cruzi, the causative agent of American trypanosomiasis. Methods used included differential scanning calorimetry, thermogravimetry, hot stage microscopy, polarized light microscopy (PLM), Fourier-transform infrared (FTIR) spectroscopy, and high-resolution X-ray powder diffraction (HR-XRPD). According to PLM and HR-XRPD data, PNQ crystallized as red oolitic crystals (absolute methanol) or prisms (dimethyl sulfoxide [DMSO]-water) with the same internal structure. The findings obtained with HR-XRPD data (applying molecular location methods) showed a monoclinic unit cell [a=18.4437(1)\u00c5, b=3.9968(2) \u00c5, c=14.5304(1) \u00c5, \u03b1=90\u00b0, \u03b2=102.71(6)\u00b0, \u03b3=90\u00b0, V=1044.9(1) \u00c53, Z=4, space group P21/c], and a crystal structure (excluding H-positions) described by parallel layers in the direction of theb-axis, with molecules held by homochemical (phenyl-phenyl and pyrazole-pyrazole) van der Waals interactions. In addition, FTIR spectra displayed the NH-pyrazole stretch overlapped with the OH absorption at 3222 cm\u22121, typical of-NH and-OH groups associated through H-bondings; and a carbonyl stretching absorption at 1694 cm\u22121, indicating a non-extensively H-bonded quinonic C=O, which was in accordance with the solved crystal structure of PNQ. The existence of such cohesive forces shed light on the thermo-analytical data, which revealed that PNQ is a stable solid, unaffected by oxygen that decomposed without melting above 260\u00b0C.", 
    "genre": "article", 
    "id": "sg:pub.10.1208/pt060482", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1023420", 
        "issn": [
          "1530-9932"
        ], 
        "name": "AAPS PharmSciTech", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "crystal structure", 
      "polarized light microscopy", 
      "van der Waals interactions", 
      "der Waals interactions", 
      "ray powder diffraction", 
      "differential scanning calorimetry", 
      "hot stage microscopy", 
      "monoclinic unit cell", 
      "Waals interactions", 
      "FTIR spectra", 
      "OH groups", 
      "powder diffraction", 
      "scanning calorimetry", 
      "crystalline structure", 
      "new antitrypanosomal compounds", 
      "stage microscopy", 
      "thermo-analytical data", 
      "such cohesive forces", 
      "OH absorption", 
      "physicochemical characteristics", 
      "antitrypanosomal compounds", 
      "cohesive forces", 
      "unit cell", 
      "microscopy", 
      "structure", 
      "thermogravimetry", 
      "spectroscopy", 
      "absorption", 
      "same internal structure", 
      "diffraction", 
      "carbonyl", 
      "parallel layers", 
      "bonding", 
      "calorimetry", 
      "compounds", 
      "molecules", 
      "NH", 
      "PNQ", 
      "oxygen", 
      "crystals", 
      "spectra", 
      "American trypanosomiasis", 
      "physical characteristics", 
      "internal structure", 
      "layer", 
      "interaction", 
      "agents", 
      "light", 
      "addition", 
      "method", 
      "prism", 
      "characteristics", 
      "force", 
      "light microscopy", 
      "group", 
      "trypanosomiasis", 
      "stretch", 
      "cruzi", 
      "accordance", 
      "existence", 
      "study", 
      "data", 
      "cells", 
      "direction", 
      "causative agent", 
      "findings", 
      "new active compound againstTrypanosoma cruzi", 
      "active compound againstTrypanosoma cruzi", 
      "compound againstTrypanosoma cruzi", 
      "againstTrypanosoma cruzi", 
      "HR-XRPD data", 
      "red oolitic crystals", 
      "oolitic crystals", 
      "theb-axis", 
      "homochemical (phenyl-phenyl and pyrazole-pyrazole) van der Waals interactions", 
      "NH-pyrazole stretch", 
      "quinonic C"
    ], 
    "name": "The crystal structure and physicochemical characteristics of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine, a new antitrypanosomal compound", 
    "pagination": "e655-e663", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022919464"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1208/pt060482"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16408868"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1208/pt060482", 
      "https://app.dimensions.ai/details/publication/pub.1022919464"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_411.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1208/pt060482"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1208/pt060482'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1208/pt060482'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1208/pt060482'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1208/pt060482'


 

This table displays all metadata directly associated to this object as RDF triples.

214 TRIPLES      22 PREDICATES      113 URIs      101 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1208/pt060482 schema:about N111bd003db744f1d8a8909cd1c7a794f
2 N2ad428ad5bcb4f3b9c5ae0e35e69e073
3 N86b93fbe66434247860035d96ecc1db1
4 N8e4e48a2ce9e473d970c1bd0d608e05d
5 Naf1301c462104623b174b74c406b547c
6 Nb1f54141558746309cde968435b09d88
7 anzsrc-for:11
8 anzsrc-for:1115
9 schema:author N20db19dce09d4050963f8b7c9115f0f4
10 schema:citation sg:pub.10.1007/bf02549315
11 sg:pub.10.1023/a:1016212804288
12 sg:pub.10.1023/a:1018832526093
13 sg:pub.10.1038/35005132
14 schema:datePublished 2005-12-27
15 schema:datePublishedReg 2005-12-27
16 schema:description This study was designed to investigate the physical characteristics and crystalline structure of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine (PNQ), a new active compound againstTrypanosoma cruzi, the causative agent of American trypanosomiasis. Methods used included differential scanning calorimetry, thermogravimetry, hot stage microscopy, polarized light microscopy (PLM), Fourier-transform infrared (FTIR) spectroscopy, and high-resolution X-ray powder diffraction (HR-XRPD). According to PLM and HR-XRPD data, PNQ crystallized as red oolitic crystals (absolute methanol) or prisms (dimethyl sulfoxide [DMSO]-water) with the same internal structure. The findings obtained with HR-XRPD data (applying molecular location methods) showed a monoclinic unit cell [a=18.4437(1)Å, b=3.9968(2) Å, c=14.5304(1) Å, α=90°, β=102.71(6)°, γ=90°, V=1044.9(1) Å3, Z=4, space group P21/c], and a crystal structure (excluding H-positions) described by parallel layers in the direction of theb-axis, with molecules held by homochemical (phenyl-phenyl and pyrazole-pyrazole) van der Waals interactions. In addition, FTIR spectra displayed the NH-pyrazole stretch overlapped with the OH absorption at 3222 cm−1, typical of-NH and-OH groups associated through H-bondings; and a carbonyl stretching absorption at 1694 cm−1, indicating a non-extensively H-bonded quinonic C=O, which was in accordance with the solved crystal structure of PNQ. The existence of such cohesive forces shed light on the thermo-analytical data, which revealed that PNQ is a stable solid, unaffected by oxygen that decomposed without melting above 260°C.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree true
20 schema:isPartOf N25521fa46bcf43fb91dcb8eb50aa4f18
21 N93367fa45e0b4fffb782e4ccd3aaf546
22 sg:journal.1023420
23 schema:keywords American trypanosomiasis
24 FTIR spectra
25 HR-XRPD data
26 NH
27 NH-pyrazole stretch
28 OH absorption
29 OH groups
30 PNQ
31 Waals interactions
32 absorption
33 accordance
34 active compound againstTrypanosoma cruzi
35 addition
36 againstTrypanosoma cruzi
37 agents
38 antitrypanosomal compounds
39 bonding
40 calorimetry
41 carbonyl
42 causative agent
43 cells
44 characteristics
45 cohesive forces
46 compound againstTrypanosoma cruzi
47 compounds
48 cruzi
49 crystal structure
50 crystalline structure
51 crystals
52 data
53 der Waals interactions
54 differential scanning calorimetry
55 diffraction
56 direction
57 existence
58 findings
59 force
60 group
61 homochemical (phenyl-phenyl and pyrazole-pyrazole) van der Waals interactions
62 hot stage microscopy
63 interaction
64 internal structure
65 layer
66 light
67 light microscopy
68 method
69 microscopy
70 molecules
71 monoclinic unit cell
72 new active compound againstTrypanosoma cruzi
73 new antitrypanosomal compounds
74 oolitic crystals
75 oxygen
76 parallel layers
77 physical characteristics
78 physicochemical characteristics
79 polarized light microscopy
80 powder diffraction
81 prism
82 quinonic C
83 ray powder diffraction
84 red oolitic crystals
85 same internal structure
86 scanning calorimetry
87 spectra
88 spectroscopy
89 stage microscopy
90 stretch
91 structure
92 study
93 such cohesive forces
94 theb-axis
95 thermo-analytical data
96 thermogravimetry
97 trypanosomiasis
98 unit cell
99 van der Waals interactions
100 schema:name The crystal structure and physicochemical characteristics of 2-hydroxy-N-[3(5)-pyrazolyl]-1,4-naphthoquinone-4-imine, a new antitrypanosomal compound
101 schema:pagination e655-e663
102 schema:productId N8fdd92a5d7e14c5797178b2076512fa9
103 Nd62fd0018ebc4026a4edab0f4b4a3463
104 Nfaa2854f69aa4201aefa0ab2c2696da7
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022919464
106 https://doi.org/10.1208/pt060482
107 schema:sdDatePublished 2021-12-01T19:17
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher N7d0d2a137e3747dd8f331fc1cd85b7d7
110 schema:url https://doi.org/10.1208/pt060482
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N111bd003db744f1d8a8909cd1c7a794f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Imines
116 rdf:type schema:DefinedTerm
117 N20db19dce09d4050963f8b7c9115f0f4 rdf:first sg:person.01251266624.24
118 rdf:rest Ne893991a1194450083c17a4e1d6f5368
119 N25521fa46bcf43fb91dcb8eb50aa4f18 schema:volumeNumber 6
120 rdf:type schema:PublicationVolume
121 N2ad428ad5bcb4f3b9c5ae0e35e69e073 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Naphthoquinones
123 rdf:type schema:DefinedTerm
124 N37664d1ad0f8472ba97a7515cefc3c4a rdf:first sg:person.0751340267.90
125 rdf:rest N8dca39dd808e4adeafccb0bf4ca855b5
126 N7d0d2a137e3747dd8f331fc1cd85b7d7 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N86b93fbe66434247860035d96ecc1db1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Crystallization
130 rdf:type schema:DefinedTerm
131 N8dca39dd808e4adeafccb0bf4ca855b5 rdf:first sg:person.011406475413.26
132 rdf:rest Nbdbc494740764c389d6dea0dfbbad734
133 N8e4e48a2ce9e473d970c1bd0d608e05d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Antiprotozoal Agents
135 rdf:type schema:DefinedTerm
136 N8fdd92a5d7e14c5797178b2076512fa9 schema:name pubmed_id
137 schema:value 16408868
138 rdf:type schema:PropertyValue
139 N93367fa45e0b4fffb782e4ccd3aaf546 schema:issueNumber 4
140 rdf:type schema:PublicationIssue
141 Naf1301c462104623b174b74c406b547c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Chemical Phenomena
143 rdf:type schema:DefinedTerm
144 Nb1f54141558746309cde968435b09d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Chemistry, Physical
146 rdf:type schema:DefinedTerm
147 Nbdbc494740764c389d6dea0dfbbad734 rdf:first sg:person.01036212433.54
148 rdf:rest rdf:nil
149 Nd62fd0018ebc4026a4edab0f4b4a3463 schema:name dimensions_id
150 schema:value pub.1022919464
151 rdf:type schema:PropertyValue
152 Ne893991a1194450083c17a4e1d6f5368 rdf:first sg:person.0675413661.16
153 rdf:rest N37664d1ad0f8472ba97a7515cefc3c4a
154 Nfaa2854f69aa4201aefa0ab2c2696da7 schema:name doi
155 schema:value 10.1208/pt060482
156 rdf:type schema:PropertyValue
157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
158 schema:name Medical and Health Sciences
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
161 schema:name Pharmacology and Pharmaceutical Sciences
162 rdf:type schema:DefinedTerm
163 sg:journal.1023420 schema:issn 1530-9932
164 schema:name AAPS PharmSciTech
165 schema:publisher Springer Nature
166 rdf:type schema:Periodical
167 sg:person.01036212433.54 schema:affiliation grid-institutes:grid.36425.36
168 schema:familyName Stephens
169 schema:givenName Peter W.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036212433.54
171 rdf:type schema:Person
172 sg:person.011406475413.26 schema:affiliation grid-institutes:grid.36425.36
173 schema:familyName Pagola
174 schema:givenName Silvina
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011406475413.26
176 rdf:type schema:Person
177 sg:person.01251266624.24 schema:affiliation grid-institutes:grid.10692.3c
178 schema:familyName Sperandeo
179 schema:givenName Norma R.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251266624.24
181 rdf:type schema:Person
182 sg:person.0675413661.16 schema:affiliation grid-institutes:grid.10692.3c
183 schema:familyName Karlsson
184 schema:givenName Alicia
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675413661.16
186 rdf:type schema:Person
187 sg:person.0751340267.90 schema:affiliation grid-institutes:grid.473248.e
188 schema:familyName Cuffini
189 schema:givenName Silvia
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751340267.90
191 rdf:type schema:Person
192 sg:pub.10.1007/bf02549315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034615055
193 https://doi.org/10.1007/bf02549315
194 rdf:type schema:CreativeWork
195 sg:pub.10.1023/a:1016212804288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037126380
196 https://doi.org/10.1023/a:1016212804288
197 rdf:type schema:CreativeWork
198 sg:pub.10.1023/a:1018832526093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042276013
199 https://doi.org/10.1023/a:1018832526093
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/35005132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025974202
202 https://doi.org/10.1038/35005132
203 rdf:type schema:CreativeWork
204 grid-institutes:grid.10692.3c schema:alternateName Cátedra de Métodos de Investigación de Minerales, Facultad Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina
205 Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina
206 schema:name Cátedra de Métodos de Investigación de Minerales, Facultad Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina
207 Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000, Córdoba, Argentina
208 rdf:type schema:Organization
209 grid-institutes:grid.36425.36 schema:alternateName Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY
210 schema:name Department of Physics and Astronomy, SUNY at Stony Brook, 11974-3800, Stony Brook, NY
211 rdf:type schema:Organization
212 grid-institutes:grid.473248.e schema:alternateName Agencia Córdoba Ciencia, CEPROCOR, Córdoba, Argentina
213 schema:name Agencia Córdoba Ciencia, CEPROCOR, Córdoba, Argentina
214 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...