Nonviral gene delivery: What we know and what is next View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-03

AUTHORS

Xiang Gao, Keun-Sik Kim, Dexi Liu

ABSTRACT

Gene delivery using nonviral approaches has been extensively studied as a basic tool for intracellular gene transfer and gene therapy. In the past, the primary focus has been on application of physical, chemical, and biological principles to development of a safe and efficient method that delivers a transgene into target cells for appropriate expression. This review summarizes the current status of the most commonly used nonviral methods, with an emphasis on their mechanism of action for gene delivery, and their advantages and limitations for gene therapy applications. The technical aspects of each delivery system are also reviewed, with a focus on how to achieve optimal delivery efficiency. A brief discussion of future development and further improvement of the current systems is intended to stimulate new ideas and encourage rapid advancement in this new and promising field. More... »

PAGES

e92-e104

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  • Journal

    TITLE

    The AAPS Journal

    ISSUE

    1

    VOLUME

    9

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1208/aapsj0901009

    DOI

    http://dx.doi.org/10.1208/aapsj0901009

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002409643

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17408239


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