Oral Administration of Docosahexaenoic Acid/Eicosapentaeinoic Acids Is Not Anticonvulsant in Rats: Implications for Translational Research View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

NICCOLO CURATOLO, CÉCILE LECOINTE, REGIS BORDET, LOUIS VALLÉE, CLAUDE GALABERT, PIERRE GRESSENS, STÉPHANE AUVIN

ABSTRACT

Omega-3 and omega-6 poly-unsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiological processes in the brain. Although experimental data have shown that PUFAs have anticonvulsant properties, the outcomes of clinical trials have been controversial. Docosahexaenoic acid (DHA) is a PUFA which has been reported to exert anticonvulsant effects. Here we studied anticonvulsant potential of a mixture of enriched n-3 PUFA upon their oral administration in rats. We did not observe an anticonvulsant effect of n-3 PUFA in the i.v. pentylentetrazol threshold test. n-3 PUFA component was increased in the plasma of rats treated with the eicosapentaenoic acid (EPA)/DHA mix (275 mg/kg/d/400 mg/kg/d) due to the increase of both DHA and EPA. We also found modification of PUFA composition in the brain. Despite PUFA profiles modified both in plasma and in the brain, we did not find any anticonvulsant effect of orally administered DHA. Further studies are needed to define the type and the amount of fatty acids that would possess anticonvulsant properties. As the existing literature suggests that the route of administration of PUFA may be crucial, future studies should involve oral administration to provide relevant clinical information. More... »

PAGES

584-588

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/pdr.0b013e31823277d9

DOI

http://dx.doi.org/10.1203/pdr.0b013e31823277d9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022343007

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21857379


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22 schema:description Omega-3 and omega-6 poly-unsaturated fatty acids (PUFAs) are dietary fatty acids that are involved in a myriad of physiological processes in the brain. Although experimental data have shown that PUFAs have anticonvulsant properties, the outcomes of clinical trials have been controversial. Docosahexaenoic acid (DHA) is a PUFA which has been reported to exert anticonvulsant effects. Here we studied anticonvulsant potential of a mixture of enriched n-3 PUFA upon their oral administration in rats. We did not observe an anticonvulsant effect of n-3 PUFA in the i.v. pentylentetrazol threshold test. n-3 PUFA component was increased in the plasma of rats treated with the eicosapentaenoic acid (EPA)/DHA mix (275 mg/kg/d/400 mg/kg/d) due to the increase of both DHA and EPA. We also found modification of PUFA composition in the brain. Despite PUFA profiles modified both in plasma and in the brain, we did not find any anticonvulsant effect of orally administered DHA. Further studies are needed to define the type and the amount of fatty acids that would possess anticonvulsant properties. As the existing literature suggests that the route of administration of PUFA may be crucial, future studies should involve oral administration to provide relevant clinical information.
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29 schema:keywords Acid/Eicosapentaeinoic Acids
30 Docosahexaenoic Acid/Eicosapentaeinoic Acids
31 Eicosapentaeinoic Acids
32 Further studies
33 PUFA components
34 PUFA composition
35 PUFA profiles
36 acid
37 administration
38 amount
39 anticonvulsant effects
40 anticonvulsant potential
41 anticonvulsant properties
42 brain
43 clinical information
44 clinical trials
45 components
46 composition
47 data
48 dietary fatty acids
49 docosahexaenoic acid
50 effect
51 eicosapentaenoic acid
52 experimental data
53 fatty acids
54 future studies
55 implications
56 increase
57 information
58 literature
59 mix
60 mixture
61 modification
62 myriad
63 n-3 PUFA component
64 n-3 poly-unsaturated fatty acids
65 omega-3
66 omega-6 poly-unsaturated fatty acids
67 oral administration
68 outcomes
69 physiological processes
70 plasma
71 plasma of rats
72 poly-unsaturated fatty acids
73 potential
74 process
75 profile
76 properties
77 rats
78 relevant clinical information
79 research
80 route
81 route of administration
82 study
83 translational research
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