Baby STEPS: A Giant Leap for Cell Therapy in Neonatal Brain Injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

CESAR V. BORLONGAN, MICHAEL D. WEISS

ABSTRACT

We advance Baby STEPS or Stem cell Therapeutics as an Emerging Paradigm in Stroke as a guide in facilitating the critical evaluation in the laboratory of the safety and efficacy of cell therapy for neonatal encephalopathy. The need to carefully consider the clinical relevance of the animal models in mimicking human neonatal brain injury, selection of the optimal stem cell donor, and the application of functional outcome assays in small and large animal models serve as the foundation for preclinical work and beginning to understand the mechanism of this cellular therapy. The preclinical studies will aid our formulation of a rigorous human clinical trial that encompasses not only efficacy testing but also monitoring of safety indices and demonstration of mechanisms of action. This schema forms the basis of Baby STEPS. Our goal is to resonate the urgent call to enhance the successful translation of cell therapy from the laboratory to the clinic. More... »

PAGES

3-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/pdr.0b013e31821d0d00

DOI

http://dx.doi.org/10.1203/pdr.0b013e31821d0d00

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014136050

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21659957


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