New Insights Into the Pathogenesis and Treatment of Necrotizing Enterocolitis: Toll-Like Receptors and Beyond View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

AMIN AFRAZI, CHHINDER P. SODHI, WARD RICHARDSON, MATTHEW NEAL, MISTY GOOD, RICHARD SIGGERS, DAVID J. HACKAM

ABSTRACT

Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in the preterm infant. The dismal results of current treatment for NEC highlight the urgent need for greater understanding of the pathogenesis of this disease, and the importance of discovering novel, molecular-specific therapies for it. Current dogma indicates that NEC development reflects an abnormal response by the premature infant to the microbial flora that colonizes the gastrointestinal tract, although the mechanisms that mediate these abnormal bacterial-enterocyte interactions and the reasons for the particularly increased susceptibility of the premature infant to the development of NEC remain incompletely explained. Recent evidence has shed light on an emerging role for the Toll-like receptors (TLRs) of the innate immune system as central players in the pathways that signal in response to enteric bacteria resulting in the development of NEC. We now review recent advances in the field of NEC and identify several exciting potential avenues for novel treatments by focusing on abnormal TLR4 signaling in the premature intestine in the pathogenesis of NEC. In so doing, we seek to offer new hope to the patients and their families who are affected by this devastating disorder. More... »

PAGES

183-188

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/pdr.0b013e3182093280

DOI

http://dx.doi.org/10.1203/pdr.0b013e3182093280

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006185282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21135755


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