Ontogeny of MMPs and TIMPs in the Murine Neocortex View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-03

AUTHORS

NATHALIE BEDNAREK, YAN CLÉMENT, VINCENT LELIÈVRE, PAUL OLIVIER, GAUTHIER LORON, ROSELYNE GARNOTEL, PIERRE GRESSENS

ABSTRACT

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in normal brain development, adult stroke, and, more recently, perinatal brain injury. Here, our objective was to obtain comprehensive and comparative data on the ontogeny of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the neocortex of male and female mice belonging to various strains, from embryonic life to adulthood. We used gelatin zymography, ELISA, and real-time PCR analyses. MMP-2, MMP-9, and TIMP-1 activity and/or expression peaked during embryonic life and the early neonatal period, whereas TIMP-2 peaked during the first two postnatal weeks. Comparable results were obtained in all the mouse strains except BALB/c, where MMP-2 levels were considerably lower at all ages compared with the other strains. No gender effect was observed on any of the study parameters. This comprehensive study will serve as a basis for future investigations into the role for MMPs and TIMPs in normal brain development and prenatal brain injury. More... »

PAGES

296-300

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181973aee

DOI

http://dx.doi.org/10.1203/pdr.0b013e3181973aee

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028082515

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19092727


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme-Linked Immunosorbent Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Mutant Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neocortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Species Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Inhibitor of Metalloproteinases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "BEDNAREK", 
        "givenName": "NATHALIE", 
        "id": "sg:person.0746467141.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746467141.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "CL\u00c9MENT", 
        "givenName": "YAN", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LELI\u00c8VRE", 
        "givenName": "VINCENT", 
        "id": "sg:person.01351771056.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351771056.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "OLIVIER", 
        "givenName": "PAUL", 
        "id": "sg:person.0662223150.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662223150.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LORON", 
        "givenName": "GAUTHIER", 
        "id": "sg:person.01205731263.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205731263.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "GARNOTEL", 
        "givenName": "ROSELYNE", 
        "id": "sg:person.01352220636.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352220636.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Facult\u00e9 de M\u00e9decine Denis Diderot [N.B., P.O., G.L., P.G.], Universit\u00e9 Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de M\u00e9decine N\u00e9onatale, Reims 51100, France; AP HP, Service de Neurologie P\u00e9diatrique [P.G.], H\u00f4pital Robert Debr\u00e9, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Universit\u00e9 de Reims Champagne-Ardenne, Reims Cedex 51095, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "GRESSENS", 
        "givenName": "PIERRE", 
        "id": "sg:person.0643134421.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00157684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008182837", 
          "https://doi.org/10.1007/bf00157684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003459355", 
          "https://doi.org/10.1038/nm1387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012833247", 
          "https://doi.org/10.1038/sj.gt.3302894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/39878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034979920", 
          "https://doi.org/10.1038/39878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199806000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064213641", 
          "https://doi.org/10.1203/00006450-199806000-00005"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-03", 
    "datePublishedReg": "2009-03-01", 
    "description": "Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in normal brain development, adult stroke, and, more recently, perinatal brain injury. Here, our objective was to obtain comprehensive and comparative data on the ontogeny of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the neocortex of male and female mice belonging to various strains, from embryonic life to adulthood. We used gelatin zymography, ELISA, and real-time PCR analyses. MMP-2, MMP-9, and TIMP-1 activity and/or expression peaked during embryonic life and the early neonatal period, whereas TIMP-2 peaked during the first two postnatal weeks. Comparable results were obtained in all the mouse strains except BALB/c, where MMP-2 levels were considerably lower at all ages compared with the other strains. No gender effect was observed on any of the study parameters. This comprehensive study will serve as a basis for future investigations into the role for MMPs and TIMPs in normal brain development and prenatal brain injury.", 
    "genre": "article", 
    "id": "sg:pub.10.1203/pdr.0b013e3181973aee", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "65"
      }
    ], 
    "keywords": [
      "normal brain development", 
      "matrix metalloproteinases", 
      "brain injury", 
      "MMP-9", 
      "MMP-2", 
      "TIMP-2", 
      "brain development", 
      "prenatal brain injury", 
      "perinatal brain injury", 
      "early neonatal period", 
      "MMP-2 levels", 
      "BALB/c", 
      "TIMP-1 activity", 
      "embryonic life", 
      "adult stroke", 
      "neonatal period", 
      "female mice", 
      "postnatal week", 
      "TIMP-1", 
      "murine neocortex", 
      "gelatin zymography", 
      "tissue inhibitor", 
      "study parameters", 
      "real-time PCR analysis", 
      "injury", 
      "neocortex", 
      "mice", 
      "TIMPs", 
      "PCR analysis", 
      "future investigations", 
      "gender effects", 
      "comparative data", 
      "stroke", 
      "ELISA", 
      "metalloproteinases", 
      "weeks", 
      "zymography", 
      "age", 
      "adulthood", 
      "comparable results", 
      "inhibitors", 
      "life", 
      "ontogeny", 
      "strains", 
      "expression", 
      "period", 
      "levels", 
      "development", 
      "activity", 
      "study", 
      "role", 
      "effect", 
      "objective", 
      "data", 
      "investigation", 
      "analysis", 
      "results", 
      "comprehensive study", 
      "basis", 
      "parameters", 
      "Ontogeny of MMPs"
    ], 
    "name": "Ontogeny of MMPs and TIMPs in the Murine Neocortex", 
    "pagination": "296-300", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028082515"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/pdr.0b013e3181973aee"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19092727"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/pdr.0b013e3181973aee", 
      "https://app.dimensions.ai/details/publication/pub.1028082515"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1203/pdr.0b013e3181973aee"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181973aee'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181973aee'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181973aee'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/pdr.0b013e3181973aee'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      22 PREDICATES      107 URIs      94 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/pdr.0b013e3181973aee schema:about N07f3d4b7f63242f6a6ed61f3d7eb4375
2 N0969357e446346649fc57fd07e9779a8
3 N13fb8b2c6e6f479ea99ae0aace8cffda
4 N3bd245fee86f4686bad128bf0e8af5e7
5 N5e4712c8f5a74fe7af4bd34f772f8879
6 N6ed554db7c6f422f9dbdb55812c64674
7 N735bd21ebcfe43cd99cb337b63ea564c
8 N758f4050e1aa4c0db2feca0f14172d24
9 N76400e90302a402390cbf8e8194b89de
10 N92113add3d1d40bdb9321758e64fbaf0
11 N9580e3439bc14dec8f8203013cdd1935
12 N97b4671818b94d20983692dd22f133c1
13 Na1a482a389ca4f2780ac94fb3fbd7a60
14 Nebb4ec592cc9413891b07aee8b320ed7
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author Nbc561a145bd24dbd838552a8903b116b
18 schema:citation sg:pub.10.1007/bf00157684
19 sg:pub.10.1038/39878
20 sg:pub.10.1038/nm1387
21 sg:pub.10.1038/sj.gt.3302894
22 sg:pub.10.1203/00006450-199806000-00005
23 schema:datePublished 2009-03
24 schema:datePublishedReg 2009-03-01
25 schema:description Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) have been implicated in normal brain development, adult stroke, and, more recently, perinatal brain injury. Here, our objective was to obtain comprehensive and comparative data on the ontogeny of MMP-2, MMP-9, TIMP-1, and TIMP-2 in the neocortex of male and female mice belonging to various strains, from embryonic life to adulthood. We used gelatin zymography, ELISA, and real-time PCR analyses. MMP-2, MMP-9, and TIMP-1 activity and/or expression peaked during embryonic life and the early neonatal period, whereas TIMP-2 peaked during the first two postnatal weeks. Comparable results were obtained in all the mouse strains except BALB/c, where MMP-2 levels were considerably lower at all ages compared with the other strains. No gender effect was observed on any of the study parameters. This comprehensive study will serve as a basis for future investigations into the role for MMPs and TIMPs in normal brain development and prenatal brain injury.
26 schema:genre article
27 schema:inLanguage en
28 schema:isAccessibleForFree true
29 schema:isPartOf N1c93238db7724494bfbc6d4b60cc767c
30 N61936d293dc84e8a87c52e6f8949f928
31 sg:journal.1007352
32 schema:keywords BALB/c
33 ELISA
34 MMP-2
35 MMP-2 levels
36 MMP-9
37 Ontogeny of MMPs
38 PCR analysis
39 TIMP-1
40 TIMP-1 activity
41 TIMP-2
42 TIMPs
43 activity
44 adult stroke
45 adulthood
46 age
47 analysis
48 basis
49 brain development
50 brain injury
51 comparable results
52 comparative data
53 comprehensive study
54 data
55 development
56 early neonatal period
57 effect
58 embryonic life
59 expression
60 female mice
61 future investigations
62 gelatin zymography
63 gender effects
64 inhibitors
65 injury
66 investigation
67 levels
68 life
69 matrix metalloproteinases
70 metalloproteinases
71 mice
72 murine neocortex
73 neocortex
74 neonatal period
75 normal brain development
76 objective
77 ontogeny
78 parameters
79 perinatal brain injury
80 period
81 postnatal week
82 prenatal brain injury
83 real-time PCR analysis
84 results
85 role
86 strains
87 stroke
88 study
89 study parameters
90 tissue inhibitor
91 weeks
92 zymography
93 schema:name Ontogeny of MMPs and TIMPs in the Murine Neocortex
94 schema:pagination 296-300
95 schema:productId N148d8a4c531442b68b299fe5f1e645ed
96 N2f44f9feb44941e0926ac596903a22f2
97 Ne14ad19f9b5743c48b5928391d537621
98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028082515
99 https://doi.org/10.1203/pdr.0b013e3181973aee
100 schema:sdDatePublished 2021-12-01T19:22
101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
102 schema:sdPublisher Nc3027eb3e646464a9809bae7ca0712e5
103 schema:url https://doi.org/10.1203/pdr.0b013e3181973aee
104 sgo:license sg:explorer/license/
105 sgo:sdDataset articles
106 rdf:type schema:ScholarlyArticle
107 N07f3d4b7f63242f6a6ed61f3d7eb4375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Gene Expression Regulation, Developmental
109 rdf:type schema:DefinedTerm
110 N0969357e446346649fc57fd07e9779a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mice
112 rdf:type schema:DefinedTerm
113 N13fb8b2c6e6f479ea99ae0aace8cffda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Reverse Transcriptase Polymerase Chain Reaction
115 rdf:type schema:DefinedTerm
116 N148d8a4c531442b68b299fe5f1e645ed schema:name dimensions_id
117 schema:value pub.1028082515
118 rdf:type schema:PropertyValue
119 N18a7984b14a14dc495d4939a070bf90b rdf:first Na591d59f17af4f56822878636e8e0adf
120 rdf:rest N6cc74a09962945e2b85dc667576340e9
121 N1c93238db7724494bfbc6d4b60cc767c schema:issueNumber 3
122 rdf:type schema:PublicationIssue
123 N2f44f9feb44941e0926ac596903a22f2 schema:name pubmed_id
124 schema:value 19092727
125 rdf:type schema:PropertyValue
126 N3bd245fee86f4686bad128bf0e8af5e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Age Factors
128 rdf:type schema:DefinedTerm
129 N460d9516ccb144df970a5f397b8fa9f3 rdf:first sg:person.0643134421.39
130 rdf:rest rdf:nil
131 N5e4712c8f5a74fe7af4bd34f772f8879 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Male
133 rdf:type schema:DefinedTerm
134 N61936d293dc84e8a87c52e6f8949f928 schema:volumeNumber 65
135 rdf:type schema:PublicationVolume
136 N6cc74a09962945e2b85dc667576340e9 rdf:first sg:person.01351771056.99
137 rdf:rest Nf4afc7b076424f3ea33580844b2c07f9
138 N6ed554db7c6f422f9dbdb55812c64674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Electrophoresis
140 rdf:type schema:DefinedTerm
141 N70cf8aa53e404e7abb2ff6d7a235fc75 rdf:first sg:person.01352220636.76
142 rdf:rest N460d9516ccb144df970a5f397b8fa9f3
143 N735bd21ebcfe43cd99cb337b63ea564c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Tissue Inhibitor of Metalloproteinases
145 rdf:type schema:DefinedTerm
146 N758f4050e1aa4c0db2feca0f14172d24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N76400e90302a402390cbf8e8194b89de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Animals
151 rdf:type schema:DefinedTerm
152 N7de58a250e3b4ac2b8e1cc754d43788b rdf:first sg:person.01205731263.15
153 rdf:rest N70cf8aa53e404e7abb2ff6d7a235fc75
154 N92113add3d1d40bdb9321758e64fbaf0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Neocortex
156 rdf:type schema:DefinedTerm
157 N9580e3439bc14dec8f8203013cdd1935 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice, Mutant Strains
159 rdf:type schema:DefinedTerm
160 N97b4671818b94d20983692dd22f133c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Enzyme-Linked Immunosorbent Assay
162 rdf:type schema:DefinedTerm
163 Na1a482a389ca4f2780ac94fb3fbd7a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Matrix Metalloproteinases
165 rdf:type schema:DefinedTerm
166 Na591d59f17af4f56822878636e8e0adf schema:affiliation grid-institutes:None
167 schema:familyName CLÉMENT
168 schema:givenName YAN
169 rdf:type schema:Person
170 Nbc561a145bd24dbd838552a8903b116b rdf:first sg:person.0746467141.07
171 rdf:rest N18a7984b14a14dc495d4939a070bf90b
172 Nc3027eb3e646464a9809bae7ca0712e5 schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 Ne14ad19f9b5743c48b5928391d537621 schema:name doi
175 schema:value 10.1203/pdr.0b013e3181973aee
176 rdf:type schema:PropertyValue
177 Nebb4ec592cc9413891b07aee8b320ed7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Species Specificity
179 rdf:type schema:DefinedTerm
180 Nf4afc7b076424f3ea33580844b2c07f9 rdf:first sg:person.0662223150.12
181 rdf:rest N7de58a250e3b4ac2b8e1cc754d43788b
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
186 schema:name Neurosciences
187 rdf:type schema:DefinedTerm
188 sg:journal.1007352 schema:issn 0031-3998
189 1530-0447
190 schema:name Pediatric Research
191 schema:publisher Springer Nature
192 rdf:type schema:Periodical
193 sg:person.01205731263.15 schema:affiliation grid-institutes:None
194 schema:familyName LORON
195 schema:givenName GAUTHIER
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205731263.15
197 rdf:type schema:Person
198 sg:person.01351771056.99 schema:affiliation grid-institutes:None
199 schema:familyName LELIÈVRE
200 schema:givenName VINCENT
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351771056.99
202 rdf:type schema:Person
203 sg:person.01352220636.76 schema:affiliation grid-institutes:None
204 schema:familyName GARNOTEL
205 schema:givenName ROSELYNE
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352220636.76
207 rdf:type schema:Person
208 sg:person.0643134421.39 schema:affiliation grid-institutes:None
209 schema:familyName GRESSENS
210 schema:givenName PIERRE
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643134421.39
212 rdf:type schema:Person
213 sg:person.0662223150.12 schema:affiliation grid-institutes:None
214 schema:familyName OLIVIER
215 schema:givenName PAUL
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662223150.12
217 rdf:type schema:Person
218 sg:person.0746467141.07 schema:affiliation grid-institutes:None
219 schema:familyName BEDNAREK
220 schema:givenName NATHALIE
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746467141.07
222 rdf:type schema:Person
223 sg:pub.10.1007/bf00157684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008182837
224 https://doi.org/10.1007/bf00157684
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/39878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034979920
227 https://doi.org/10.1038/39878
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nm1387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003459355
230 https://doi.org/10.1038/nm1387
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.gt.3302894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012833247
233 https://doi.org/10.1038/sj.gt.3302894
234 rdf:type schema:CreativeWork
235 sg:pub.10.1203/00006450-199806000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064213641
236 https://doi.org/10.1203/00006450-199806000-00005
237 rdf:type schema:CreativeWork
238 grid-institutes:None schema:alternateName Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Faculté de Médecine Denis Diderot [N.B., P.O., G.L., P.G.], Université Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de Médecine Néonatale, Reims 51100, France; AP HP, Service de Neurologie Pédiatrique [P.G.], Hôpital Robert Debré, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Université de Reims Champagne-Ardenne, Reims Cedex 51095, France
239 schema:name Inserm, U676 [N.B., V.L., P.O., G.L., P.G.], Paris 75019, France; Faculté de Médecine Denis Diderot [N.B., P.O., G.L., P.G.], Université Paris 7, Paris 75019, France; Alix de Champagne [N.B., G.L.], Service de Médecine Néonatale, Reims 51100, France; AP HP, Service de Neurologie Pédiatrique [P.G.], Hôpital Robert Debré, Paris 75019, France; CNRS, UMR 6237 [R.G., Y.C.], Université de Reims Champagne-Ardenne, Reims Cedex 51095, France
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...