Transient Inhibition of Astrocytogenesis in Developing Mouse Brain Following Postnatal Caffeine Exposure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-11

AUTHORS

LUC DESFRERE, PAUL OLIVIER, LESLIE SCHWENDIMANN, CATHERINE VERNEY, PIERRE GRESSENS

ABSTRACT

Caffeine is frequently administered in human preterm newborns. Although some data suggest a potential risk for the developing brain, its impact has not been fully evaluated. We used a murine model of postnatal caffeine treatment in which mouse pups received intraperitoneal injections of caffeine from postnatal days 3 to 10. Caffeine exposure resulted in a transient reduction of glial fibrillary acidic protein and S100beta protein expression in various brain areas during the first 2 postnatal weeks (19.8% and 23.2% reduction in the hippocampus at P15, respectively). This effect was dose-dependent and at least partly involved a reduction of glial proliferation, as a caffeine-induced decrease of 5-bromodeoxyuridine incorporation was observed in the dentate gyrus and subventricular zone (25.8% and 26.6%, respectively) and no increase of programmed cell death (cleaved caspase-3 immunostaining) was observed at postnatal day 7. This effect could be reproduced with an antagonist of A(2a) adenosine receptor (A(2a)R) and was blocked by co-injection of an agonist. These results suggest that postnatal caffeine treatment might induce an alteration of astrocytogenesis via A(2a)R blockade during brain development. Although no obvious neuritic abnormalities (microtubule-associated protein 2 and synaptophysin immunostaining) were observed, postnatal caffeine treatment could have long-term consequences on brain function. More... »

PAGES

604-609

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/pdr.0b013e318156e425

DOI

http://dx.doi.org/10.1203/pdr.0b013e318156e425

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031861785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18049373


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38 schema:description Caffeine is frequently administered in human preterm newborns. Although some data suggest a potential risk for the developing brain, its impact has not been fully evaluated. We used a murine model of postnatal caffeine treatment in which mouse pups received intraperitoneal injections of caffeine from postnatal days 3 to 10. Caffeine exposure resulted in a transient reduction of glial fibrillary acidic protein and S100beta protein expression in various brain areas during the first 2 postnatal weeks (19.8% and 23.2% reduction in the hippocampus at P15, respectively). This effect was dose-dependent and at least partly involved a reduction of glial proliferation, as a caffeine-induced decrease of 5-bromodeoxyuridine incorporation was observed in the dentate gyrus and subventricular zone (25.8% and 26.6%, respectively) and no increase of programmed cell death (cleaved caspase-3 immunostaining) was observed at postnatal day 7. This effect could be reproduced with an antagonist of A(2a) adenosine receptor (A(2a)R) and was blocked by co-injection of an agonist. These results suggest that postnatal caffeine treatment might induce an alteration of astrocytogenesis via A(2a)R blockade during brain development. Although no obvious neuritic abnormalities (microtubule-associated protein 2 and synaptophysin immunostaining) were observed, postnatal caffeine treatment could have long-term consequences on brain function.
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46 Following Postnatal Caffeine Exposure
47 Mouse Brain Following Postnatal Caffeine Exposure
48 abnormalities
49 acidic protein
50 adenosine receptors
51 agonists
52 alteration of astrocytogenesis
53 alterations
54 antagonist
55 area
56 astrocytogenesis
57 blockade
58 brain
59 brain areas
60 brain development
61 brain function
62 caffeine
63 caffeine exposure
64 caffeine treatment
65 caffeine-induced decrease
66 cell death
67 consequences
68 data
69 day 3
70 day 7
71 death
72 decrease
73 dentate gyrus
74 development
75 effect
76 exposure
77 expression
78 fibrillary acidic protein
79 function
80 glial fibrillary acidic protein
81 glial proliferation
82 gyrus
83 human preterm newborns
84 impact
85 incorporation
86 increase
87 inhibition
88 injection
89 intraperitoneal injection
90 long-term consequences
91 model
92 mouse pups
93 murine model
94 neuritic abnormalities
95 newborns
96 obvious neuritic abnormalities
97 postnatal caffeine exposure
98 postnatal caffeine treatment
99 postnatal day 3
100 postnatal day 7
101 postnatal week
102 potential risk
103 preterm newborns
104 proliferation
105 protein
106 protein expression
107 pups
108 receptors
109 reduction
110 results
111 risk
112 subventricular zone
113 transient inhibition
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115 treatment
116 weeks
117 zone
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