Spastic Paresis After Perinatal Brain Damage in Rats Is Reduced by Human Cord Blood Mononuclear Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-02

AUTHORS

CAROLA MEIER, JOHANNES MIDDELANIS, BIANCA WASIELEWSKI, SANDRA NEUHOFF, ASTRID ROTH-HAERER, MARKUS GANTERT, HUBERT R. DINSE, ROLF DERMIETZEL, ARNE JENSEN

ABSTRACT

Brain damage around birth may cause lifelong neurodevelopmental deficits. We examined the therapeutic potential of human umbilical cord blood-derived mononuclear cells containing multipotent stem cells to facilitate motor recovery after cerebral hypoxic-ischemic damage in neonatal rats. Left carotid artery ligation followed by 8% O(2) inhalation for 80 min was performed on postnatal d 7, succeeded by intraperitoneal transplantation of human umbilical cord blood-derived mononuclear cells on postnatal d 8 in a sham-controlled design. Histologic and immunohistochemical analysis on postnatal d 21 revealed that neonates developed severe cerebral damage after the hypoxic-ischemic insult. These animals also suffered from contralateral spastic paresis, as evidenced by their locomotor behavior. After transplantation of human umbilical cord blood-derived mononuclear cells, spastic paresis was largely alleviated, resulting in a normal walking behavior. This "therapeutic" effect was accompanied by the fact that mononuclear cells had entered the brain and were incorporated around the lesion without obvious signs of transdifferentiation. This study demonstrates that intraperitoneal transplantation of human umbilical cord blood-derived mononuclear cells in a rat model of perinatal brain damage leads to both incorporation of these cells in the lesioned brain area and to an alleviation of the neurologic effects of cerebral palsy as assessed by footprint and walking pattern analysis. More... »

PAGES

244-249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/01.pdr.0000197309.08852.f5

DOI

http://dx.doi.org/10.1203/01.pdr.0000197309.08852.f5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022373812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16439586


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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000197309.08852.f5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000197309.08852.f5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000197309.08852.f5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000197309.08852.f5'


 

This table displays all metadata directly associated to this object as RDF triples.

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