Glomerular Proteinuria Induces Heme Oxygenase-1 Gene Expression within Renal Epithelial Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-10

AUTHORS

MASAKI SHIMIZU, KAZUHIDE OHTA, YONGHONG YANG, AKIKO NAKAI, TOMOKO TOMA, YUTAKA SAIKAWA, YOSHIHITO KASAHARA, AKIHIRO YACHIE, HITOSHI YOKOYAMA, HIDETOSHI SEKI, SHOICHI KOIZUMI

ABSTRACT

To clarify the patterns of heme oxygenase-1 (HO-1) production within the human kidney, we examined HO-1 mRNA expression in various renal diseases and compared the patterns with those of HO-1 protein expression and these data with the clinical features. The degrees of hematuria and proteinuria and the levels of urinary N-acetyl-beta-D-glucosaminidase (NAG), beta(2)-microglobulin (beta(2)-mg), and creatinine were determined. In situ hybridization and immunohistochemical studies were performed to evaluate HO-1 expression. HO-1 mRNA was detectable within tubular, glomerular, and Bowman's epithelial cells and infiltrating macrophages. Within the proximal tubuli, there was a correlation between expression of HO-1 protein and mRNA, but the intensity of HO-1 mRNA expression was much less than expected from the levels of protein. In contrast, both HO-1 protein and mRNA were expressed at significant levels within distal tubuli. Furthermore, there was no correlation with both expressions within distal tubuli. HO-1 mRNA expression within tubular, glomerular, and Bowman's epithelial cells tended to be more intense with greater degrees of proteinuria. However, there was little correlation between the intensity of HO-1 mRNA expression and the degree of hematuria, NAG, and beta(2)-mg. HO-1 plays important roles in maintaining renal functions by protecting renal epithelial cells from glomerular proteinuria, which can become a cause of oxidative stress. Furthermore, from the different expression pattern of HO-1 gene between within the proximal tubuli and within the distal tubuli, renal expression of HO-1 is regulated in a segment-specific manner, with HO-1 thereby playing distinct roles in different segments of the nephron to maintain renal functions. More... »

PAGES

666-671

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/01.pdr.0000180557.68222.5a

DOI

http://dx.doi.org/10.1203/01.pdr.0000180557.68222.5a

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016600526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16189191


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