Joint and Bone Disease in Mucopolysaccharidoses VI and VII: Identification of New Therapeutic Targets and BioMarkers Using Animal Models View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-05

AUTHORS

CALOGERA M. SIMONARO, MARINA D’ANGELO, MARK E. HASKINS, EDWARD H. SCHUCHMAN

ABSTRACT

The mucopolysaccharidoses (MPS) are inherited metabolic disorders resulting from the defective catabolism of glycosaminoglycans. In this report, we find that the stimulation of MPS connective tissue cells by the inflammatory cytokines causes enhanced secretion of several matrix-degrading metalloproteinases (MMPs). In addition, expression of tissue inhibitor of metalloproteinase-1 was elevated, consistent with the enhanced MMP activity. These findings were not restricted to one particular MPS disorder or species, and are consistent with previous observations in animal models with chemically induced arthritis. Bromodeoxyuridine incorporation studies also revealed that MPS chondrocytes proliferated up to 5-fold faster than normal chondrocytes, and released elevated levels of transforming growth factor-beta, presumably to counteract the marked chondrocyte apoptosis and matrix degradation associated with MMP expression. Despite this compensatory mechanism, studies of endochondral ossification revealed a reduction in chondro-differentiation in the growth plates. Thus, although MPS chondrocytes grew faster, most of the newly formed cells were immature and could not mineralize into bone. Our studies suggest that altered MMP expression, most likely stimulated by inflammatory cytokines and nitric oxide, is an important feature of the MPS disorders. These data also identify several proinflammatory cytokines, nitric oxide, and MMPs as novel therapeutic targets and/or biomarkers of MPS joint and bone disease. This information should aid in the evaluation of existing therapies for these disorders, such as enzyme replacement therapy and bone marrow transplantation, and may lead to the development of new therapeutic approaches. More... »

PAGES

701-707

References to SciGraph publications

  • 2004-05. Enzyme replacement and enhancement therapies for lysosomal diseases in JOURNAL OF INHERITED METABOLIC DISEASE
  • 2000-06. Enzyme Replacement Therapy in a Feline Model of MPS VI: Modification of Enzyme Structure and Dose Frequency in PEDIATRIC RESEARCH
  • 1995-09. Growth plate pathology in feline mucopolysaccharidosis VI in CALCIFIED TISSUE INTERNATIONAL
  • 1999-01. Autologous transplantation of retrovirally transduced bone marrow or neonatal blood cells into cats can lead to long-term engraftment in the absence of myeloablation in GENE THERAPY
  • 1984-10. β-Glucuronidase Deficiency in a Dog: a Model of Human Mucopolysaccharidosis VII in PEDIATRIC RESEARCH
  • 1984-11. Correction of feline arylsulphatase B deficiency (mucopolysaccharidosis VI) by bone marrow transplantation in NATURE
  • 1975-05. Arylsulfatase B Deficiency in Maroteaux-Lamy Syndrome: Cellular Studies and Carrier Identification in PEDIATRIC RESEARCH
  • 2001-09. Articular Chondrocytes from Animals with a Dermatan Sulfate Storage Disease Undergo a High Rate of Apoptosis and Release Nitric Oxide and Inflammatory Cytokines: A Possible Mechanism Underlying Degenerative Joint Disease in the Mucopolysaccharidoses in LABORATORY INVESTIGATION
  • 2003-10. The pathophysiology of osteoarthritis in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 1999-07. Histomorphometric Analysis of the Tibial Growth Plate in a Feline Model of Mucopolysaccharidosis Type VI in CALCIFIED TISSUE INTERNATIONAL
  • 1994-11. Metalloproteinase production by rabbit articular cartilage: comparison of the effects of interleukin-1α in vitro and in vivo in VIRCHOWS ARCHIV
  • Journal

    TITLE

    Pediatric Research

    ISSUE

    5 Part 1

    VOLUME

    57

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1203/01.pdr.0000156510.96253.5a

    DOI

    http://dx.doi.org/10.1203/01.pdr.0000156510.96253.5a

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049830888

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15746260


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