Ontology type: schema:ScholarlyArticle Open Access: True
2005-03
AUTHORSJENNIFER H. STEEL, SOTIRIS MALATOS, NIGEL KENNEA, A DAVID EDWARDS, LYNDA MILES, PHILIP DUGGAN, PETER R. REYNOLDS, ROBERT G. FELDMAN, MARK H.F. SULLIVAN
ABSTRACTIntrauterine infection has been frequently linked with preterm labor before 30 wk of human pregnancy. Many different species of organisms have been detected, leading to the suggestion that infection-induced preterm labor is a generic inflammatory response to organisms rather than a specific response to a limited number of pathogens. The detection of organisms by microbiological culture is a laborious and unreliable process, so the aim of this study was to harness modern molecular techniques to detect organisms in tissues from human pregnancy. A DNA probe specific for conserved regions of bacterial 16S ribosomal RNA sequence was designed and labeled with fluorescein for fluorescence in situ hybridization. Organisms were detected in the great majority (>80%) of fetal membranes after prolonged premature rupture of the fetal membranes and after preterm labor, which was consistent with previous data. Organisms were also detected in fetal membranes after preterm delivery without labor and in term deliveries (with or without labour). Inflammatory cells were found frequently in the amnion or chorion of preterm fetal membranes but not in term tissues. Our primary finding is that fluorescence in situ hybridization is an appropriate method to detect organisms in human fetal membranes. In addition, our data show that bacteria may be present in fetal membranes without necessarily causing an inflammatory response, so the mere presence of bacteria may not be sufficient to cause preterm labor. More... »
PAGES404-411
http://scigraph.springernature.com/pub.10.1203/01.pdr.0000153869.96337.90
DOIhttp://dx.doi.org/10.1203/01.pdr.0000153869.96337.90
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1035762631
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15659699
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JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000153869.96337.90'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000153869.96337.90'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000153869.96337.90'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/01.pdr.0000153869.96337.90'
This table displays all metadata directly associated to this object as RDF triples.
330 TRIPLES
21 PREDICATES
95 URIs
37 LITERALS
25 BLANK NODES