396 Early Endothelium-Dependent Vasodilatory Dysfunction Innormotensive, Intra-Uterine Growth Restricted Rats is Restored by L-Arginine and Inhibition of Arginases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11

AUTHORS

I Grandvuillemin, I Ligi, C Buffat, F Boubred, F Dignat-George, U Simeoni

ABSTRACT

Increasing clinical and experimental evidence demonstrates that fetalprogrammed hypertension in adulthood is associated with altered endotheliumdependent vasodilation. However, it is debated whether decreased endothelium-dependent vasodilation precedes or is a consequence of elevated arterial pressure. We studied endotheliumdependent vasodilating capacity and the L-argininenitric oxide pathway in intra-uterine growthrestricted (IUGR), 5-week-old, male rats, before the development of elevated arterial pressure. We furthermore tested the hypothesis that alteration in endothelial vasodilation may be due to a reduction in L-arginine bioavailability. More... »

PAGES

204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-201011001-00396

DOI

http://dx.doi.org/10.1203/00006450-201011001-00396

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010450595


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