Congenital Heart Disease in Maternal Phenylketonuria: Report from the Maternal PKU Collaborative Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-05

AUTHORS

Harvey L Levy, Per Guldberg, Flemming Güttler, William B Hanley, Reuben Matalon, Bobbye M Rouse, Friedrich Trefz, Colleen Azen, Elizabeth N Allred, Felix De La Cruz, Richard Koch

ABSTRACT

The frequency and types of congenital heart disease in offspring from pregnancies in women with hyperphenylalaninemia were examined in the international prospective Maternal Phenylketonuria Collaborative Study. Relationships of congenital heart disease in offspring to the basal blood phenylalanine level in the mother, metabolic control through diet during pregnancy, and phenylalanine hydroxylase mutations in mother and offspring were determined. The 416 offspring from 412 maternal phenylketonuria pregnancies that produced live births and 100 offspring from the 99 control pregnancies were included in this examination. Thirty-four of the 235 offspring (14%; 95% CI, 10.2 to 19.6%) from pregnancies in phenylketonuric women with a basal phenylalanine level ≥ 900 μM (15 mg/dL) [normal blood phenylalanine < 120 μM (2 mg/dL)] and not in metabolic control [phenylalanine level ≤ 600 μM (10 mg/dL)] by the eighth gestational week had congenital heart disease compared with one control offspring (1%) with congenital heart disease. One offspring among the 50 (2%) from mothers with non-phenylketonuria mild hyperphenylalaninemia also had congenital heart disease. Coarctation of the aorta and hypoplastic left heart syndrome were overrepresented compared with expected percentages among those with congenital heart disease in the general population. A basal maternal phenylalanine level > 1800 μM (30 mg/dL) significantly increased the risk for bearing a child with congenital heart disease (p = 0.003). Phenylalanine hydroxylase mutations in the mothers and offspring did not have an independent relationship to congenital heart disease but were related through the basal maternal phenylalanine levels. The data in this study indicate that a basal maternal phenylalanine level of 900 μM may be a threshold for congenital heart disease, that women with the most severe degree of phenylketonuria are at highest risk for bearing such a child, and that prevention of the congenital heart disease requires initiation of the low phenylalanine diet before conception or early in pregnancy with metabolic control no later than the eighth gestational week. More... »

PAGES

636-642

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-200105000-00005

DOI

http://dx.doi.org/10.1203/00006450-200105000-00005

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026646746

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11328945


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Defects, Congenital", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylalanine Hydroxylase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylketonurias", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography, Prenatal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Genetics and Neuroepidemiology Unit, Children\u2019s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Genetics and Neuroepidemiology Unit, Children\u2019s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levy", 
        "givenName": "Harvey L", 
        "id": "sg:person.01051643231.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051643231.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John F. Kennedy Institute, Glostrup, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.419352.8", 
          "name": [
            "John F. Kennedy Institute, Glostrup, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guldberg", 
        "givenName": "Per", 
        "id": "sg:person.0760021664.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "John F. Kennedy Institute, Glostrup, Denmark", 
          "id": "http://www.grid.ac/institutes/grid.419352.8", 
          "name": [
            "John F. Kennedy Institute, Glostrup, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00fcttler", 
        "givenName": "Flemming", 
        "id": "sg:person.01137432144.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137432144.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Hospital for Sick Children, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanley", 
        "givenName": "William B", 
        "id": "sg:person.0673364731.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673364731.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matalon", 
        "givenName": "Reuben", 
        "id": "sg:person.07664653317.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07664653317.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.176731.5", 
          "name": [
            "University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rouse", 
        "givenName": "Bobbye M", 
        "id": "sg:person.01234205031.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234205031.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Hospital of Reutlingen, Germany", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Children\u2019s Hospital of Reutlingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trefz", 
        "givenName": "Friedrich", 
        "id": "sg:person.010210642437.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010210642437.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Hospital of Los Angeles, Los Angeles, California, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.239546.f", 
          "name": [
            "Children\u2019s Hospital of Los Angeles, Los Angeles, California, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azen", 
        "givenName": "Colleen", 
        "id": "sg:person.0777624340.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777624340.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Genetics and Neuroepidemiology Unit, Children\u2019s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Genetics and Neuroepidemiology Unit, Children\u2019s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allred", 
        "givenName": "Elizabeth N", 
        "id": "sg:person.01165052376.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165052376.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "the National Institute of Child Health and Human Development, Bethesda, Maryland, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "the National Institute of Child Health and Human Development, Bethesda, Maryland, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "De La Cruz", 
        "givenName": "Felix", 
        "id": "sg:person.01023203544.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023203544.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children\u2019s Hospital of Los Angeles, Los Angeles, California, U.S.A.", 
          "id": "http://www.grid.ac/institutes/grid.239546.f", 
          "name": [
            "Children\u2019s Hospital of Los Angeles, Los Angeles, California, U.S.A."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koch", 
        "givenName": "Richard", 
        "id": "sg:person.0731511140.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731511140.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/pl00014236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044214966", 
          "https://doi.org/10.1007/pl00014236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0398-266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026871339", 
          "https://doi.org/10.1038/ng0398-266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199707000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064211129", 
          "https://doi.org/10.1203/00006450-199707000-00016"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-05", 
    "datePublishedReg": "2001-05-01", 
    "description": "The frequency and types of congenital heart disease in offspring from pregnancies in women with hyperphenylalaninemia were examined in the international prospective Maternal Phenylketonuria Collaborative Study. Relationships of congenital heart disease in offspring to the basal blood phenylalanine level in the mother, metabolic control through diet during pregnancy, and phenylalanine hydroxylase mutations in mother and offspring were determined. The 416 offspring from 412 maternal phenylketonuria pregnancies that produced live births and 100 offspring from the 99 control pregnancies were included in this examination. Thirty-four of the 235 offspring (14%; 95% CI, 10.2 to 19.6%) from pregnancies in phenylketonuric women with a basal phenylalanine level \u2265 900 \u03bcM (15 mg/dL) [normal blood phenylalanine < 120 \u03bcM (2 mg/dL)] and not in metabolic control [phenylalanine level \u2264 600 \u03bcM (10 mg/dL)] by the eighth gestational week had congenital heart disease compared with one control offspring (1%) with congenital heart disease. One offspring among the 50 (2%) from mothers with non-phenylketonuria mild hyperphenylalaninemia also had congenital heart disease. Coarctation of the aorta and hypoplastic left heart syndrome were overrepresented compared with expected percentages among those with congenital heart disease in the general population. A basal maternal phenylalanine level > 1800 \u03bcM (30 mg/dL) significantly increased the risk for bearing a child with congenital heart disease (p = 0.003). Phenylalanine hydroxylase mutations in the mothers and offspring did not have an independent relationship to congenital heart disease but were related through the basal maternal phenylalanine levels. The data in this study indicate that a basal maternal phenylalanine level of 900 \u03bcM may be a threshold for congenital heart disease, that women with the most severe degree of phenylketonuria are at highest risk for bearing such a child, and that prevention of the congenital heart disease requires initiation of the low phenylalanine diet before conception or early in pregnancy with metabolic control no later than the eighth gestational week.", 
    "genre": "article", 
    "id": "sg:pub.10.1203/00006450-200105000-00005", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2424028", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2430540", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "49"
      }
    ], 
    "keywords": [
      "congenital heart disease", 
      "heart disease", 
      "phenylalanine levels", 
      "eighth gestational week", 
      "metabolic control", 
      "gestational weeks", 
      "hypoplastic left heart syndrome", 
      "phenylalanine hydroxylase mutations", 
      "Maternal PKU Collaborative Study", 
      "blood phenylalanine levels", 
      "Maternal Phenylketonuria Collaborative Study", 
      "PKU Collaborative Study", 
      "low phenylalanine diet", 
      "phenylketonuric women", 
      "collaborative study", 
      "maternal phenylketonuria", 
      "control pregnancies", 
      "heart syndrome", 
      "control offspring", 
      "phenylalanine diet", 
      "severe degree", 
      "live births", 
      "general population", 
      "high risk", 
      "pregnancy", 
      "independent relationship", 
      "disease", 
      "mild hyperphenylalaninemia", 
      "women", 
      "mothers", 
      "weeks", 
      "hyperphenylalaninemia", 
      "phenylketonuria", 
      "offspring", 
      "diet", 
      "risk", 
      "children", 
      "coarctation", 
      "levels", 
      "aorta", 
      "syndrome", 
      "control", 
      "study", 
      "prevention", 
      "mutations", 
      "birth", 
      "examination", 
      "report", 
      "\u03bcM", 
      "population", 
      "percentage", 
      "initiation", 
      "relationship", 
      "threshold", 
      "frequency", 
      "data", 
      "degree", 
      "types", 
      "conception", 
      "international prospective Maternal Phenylketonuria Collaborative Study", 
      "prospective Maternal Phenylketonuria Collaborative Study", 
      "Phenylketonuria Collaborative Study", 
      "basal blood phenylalanine level", 
      "hydroxylase mutations", 
      "maternal phenylketonuria pregnancies", 
      "phenylketonuria pregnancies", 
      "basal phenylalanine level", 
      "non-phenylketonuria mild hyperphenylalaninemia", 
      "left heart syndrome", 
      "basal maternal phenylalanine level", 
      "maternal phenylalanine level"
    ], 
    "name": "Congenital Heart Disease in Maternal Phenylketonuria: Report from the Maternal PKU Collaborative Study", 
    "pagination": "636-642", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026646746"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-200105000-00005"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11328945"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-200105000-00005", 
      "https://app.dimensions.ai/details/publication/pub.1026646746"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_344.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1203/00006450-200105000-00005"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-200105000-00005'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-200105000-00005'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-200105000-00005'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-200105000-00005'


 

This table displays all metadata directly associated to this object as RDF triples.

281 TRIPLES      22 PREDICATES      112 URIs      100 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-200105000-00005 schema:about N001119c51881499c869de842cec3e783
2 N06da8b6087c3491aa4453dc159239f2a
3 N1364c2ee3d8b4830b2787a0b8c09d98b
4 N56822633fbbe4e77bc94305da37a3ffe
5 N627de2c8d088455c8d573ebd9547fd8d
6 N802e7eabe0d342a5bcd22b24f6ba65ea
7 N9be14b9444ec4b2c8e1db62ffb154ccc
8 Ncd92646886a24547aba5f39cca84d359
9 Nde68eba8323345f4b6466f37f3e5b4c8
10 Nfa0d4a4ad8594ee8b0efcb08a84e85ae
11 anzsrc-for:11
12 anzsrc-for:1102
13 anzsrc-for:1114
14 schema:author N20d9d4f32cd040efb3cb31215ea73b49
15 schema:citation sg:pub.10.1007/pl00014236
16 sg:pub.10.1038/ng0398-266
17 sg:pub.10.1203/00006450-199707000-00016
18 schema:datePublished 2001-05
19 schema:datePublishedReg 2001-05-01
20 schema:description The frequency and types of congenital heart disease in offspring from pregnancies in women with hyperphenylalaninemia were examined in the international prospective Maternal Phenylketonuria Collaborative Study. Relationships of congenital heart disease in offspring to the basal blood phenylalanine level in the mother, metabolic control through diet during pregnancy, and phenylalanine hydroxylase mutations in mother and offspring were determined. The 416 offspring from 412 maternal phenylketonuria pregnancies that produced live births and 100 offspring from the 99 control pregnancies were included in this examination. Thirty-four of the 235 offspring (14%; 95% CI, 10.2 to 19.6%) from pregnancies in phenylketonuric women with a basal phenylalanine level ≥ 900 μM (15 mg/dL) [normal blood phenylalanine < 120 μM (2 mg/dL)] and not in metabolic control [phenylalanine level ≤ 600 μM (10 mg/dL)] by the eighth gestational week had congenital heart disease compared with one control offspring (1%) with congenital heart disease. One offspring among the 50 (2%) from mothers with non-phenylketonuria mild hyperphenylalaninemia also had congenital heart disease. Coarctation of the aorta and hypoplastic left heart syndrome were overrepresented compared with expected percentages among those with congenital heart disease in the general population. A basal maternal phenylalanine level > 1800 μM (30 mg/dL) significantly increased the risk for bearing a child with congenital heart disease (p = 0.003). Phenylalanine hydroxylase mutations in the mothers and offspring did not have an independent relationship to congenital heart disease but were related through the basal maternal phenylalanine levels. The data in this study indicate that a basal maternal phenylalanine level of 900 μM may be a threshold for congenital heart disease, that women with the most severe degree of phenylketonuria are at highest risk for bearing such a child, and that prevention of the congenital heart disease requires initiation of the low phenylalanine diet before conception or early in pregnancy with metabolic control no later than the eighth gestational week.
21 schema:genre article
22 schema:inLanguage en
23 schema:isAccessibleForFree true
24 schema:isPartOf N7028618b43054f14841df468c85104b5
25 Nf3f24519da5b447e8812b7a8306ff6b5
26 sg:journal.1007352
27 schema:keywords Maternal PKU Collaborative Study
28 Maternal Phenylketonuria Collaborative Study
29 PKU Collaborative Study
30 Phenylketonuria Collaborative Study
31 aorta
32 basal blood phenylalanine level
33 basal maternal phenylalanine level
34 basal phenylalanine level
35 birth
36 blood phenylalanine levels
37 children
38 coarctation
39 collaborative study
40 conception
41 congenital heart disease
42 control
43 control offspring
44 control pregnancies
45 data
46 degree
47 diet
48 disease
49 eighth gestational week
50 examination
51 frequency
52 general population
53 gestational weeks
54 heart disease
55 heart syndrome
56 high risk
57 hydroxylase mutations
58 hyperphenylalaninemia
59 hypoplastic left heart syndrome
60 independent relationship
61 initiation
62 international prospective Maternal Phenylketonuria Collaborative Study
63 left heart syndrome
64 levels
65 live births
66 low phenylalanine diet
67 maternal phenylalanine level
68 maternal phenylketonuria
69 maternal phenylketonuria pregnancies
70 metabolic control
71 mild hyperphenylalaninemia
72 mothers
73 mutations
74 non-phenylketonuria mild hyperphenylalaninemia
75 offspring
76 percentage
77 phenylalanine diet
78 phenylalanine hydroxylase mutations
79 phenylalanine levels
80 phenylketonuria
81 phenylketonuria pregnancies
82 phenylketonuric women
83 population
84 pregnancy
85 prevention
86 prospective Maternal Phenylketonuria Collaborative Study
87 relationship
88 report
89 risk
90 severe degree
91 study
92 syndrome
93 threshold
94 types
95 weeks
96 women
97 μM
98 schema:name Congenital Heart Disease in Maternal Phenylketonuria: Report from the Maternal PKU Collaborative Study
99 schema:pagination 636-642
100 schema:productId N0449dfbd076347779ee218cfe3559324
101 N7362beb0b16d453487db49f0d241e109
102 Nb9fec755e053469895bfeb14ed961265
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026646746
104 https://doi.org/10.1203/00006450-200105000-00005
105 schema:sdDatePublished 2021-12-01T19:13
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N4dbdb3356f284d6d8c5d5181ac0a3f04
108 schema:url https://doi.org/10.1203/00006450-200105000-00005
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N001119c51881499c869de842cec3e783 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Heart Defects, Congenital
114 rdf:type schema:DefinedTerm
115 N0449dfbd076347779ee218cfe3559324 schema:name doi
116 schema:value 10.1203/00006450-200105000-00005
117 rdf:type schema:PropertyValue
118 N06da8b6087c3491aa4453dc159239f2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Phenylalanine Hydroxylase
120 rdf:type schema:DefinedTerm
121 N1364c2ee3d8b4830b2787a0b8c09d98b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Phenylketonurias
123 rdf:type schema:DefinedTerm
124 N20d9d4f32cd040efb3cb31215ea73b49 rdf:first sg:person.01051643231.51
125 rdf:rest N33eca5a68a184ea08044a5321dcb7d7a
126 N33eca5a68a184ea08044a5321dcb7d7a rdf:first sg:person.0760021664.46
127 rdf:rest N7c7752aed81f47d39b2898acfe64cc26
128 N4dbdb3356f284d6d8c5d5181ac0a3f04 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N56822633fbbe4e77bc94305da37a3ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Ultrasonography, Prenatal
132 rdf:type schema:DefinedTerm
133 N6167e55919f64e4da851522afd27b00c rdf:first sg:person.0777624340.39
134 rdf:rest N78d902c64cc645bd9a20ba3c484bc6ea
135 N627de2c8d088455c8d573ebd9547fd8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Pregnancy
137 rdf:type schema:DefinedTerm
138 N6bc52cd3f3bc4d5582038445c7cf2cbd rdf:first sg:person.01023203544.00
139 rdf:rest Nc88ebbd61d3d4ac0be8d9e7b92d67247
140 N7028618b43054f14841df468c85104b5 schema:volumeNumber 49
141 rdf:type schema:PublicationVolume
142 N7362beb0b16d453487db49f0d241e109 schema:name dimensions_id
143 schema:value pub.1026646746
144 rdf:type schema:PropertyValue
145 N78d902c64cc645bd9a20ba3c484bc6ea rdf:first sg:person.01165052376.46
146 rdf:rest N6bc52cd3f3bc4d5582038445c7cf2cbd
147 N7c7752aed81f47d39b2898acfe64cc26 rdf:first sg:person.01137432144.34
148 rdf:rest Na00ed88e00ae41449a8c4173bb1724e5
149 N802e7eabe0d342a5bcd22b24f6ba65ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Female
151 rdf:type schema:DefinedTerm
152 N9b35d4e2a0514df682699ee1f4618f66 rdf:first sg:person.010210642437.54
153 rdf:rest N6167e55919f64e4da851522afd27b00c
154 N9be14b9444ec4b2c8e1db62ffb154ccc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Humans
156 rdf:type schema:DefinedTerm
157 Na00ed88e00ae41449a8c4173bb1724e5 rdf:first sg:person.0673364731.12
158 rdf:rest Nbc053cb4920b49de8ff7241b333598f4
159 Nb03c319c4c4e4c5386e723cd37b4503f rdf:first sg:person.01234205031.40
160 rdf:rest N9b35d4e2a0514df682699ee1f4618f66
161 Nb9fec755e053469895bfeb14ed961265 schema:name pubmed_id
162 schema:value 11328945
163 rdf:type schema:PropertyValue
164 Nbc053cb4920b49de8ff7241b333598f4 rdf:first sg:person.07664653317.72
165 rdf:rest Nb03c319c4c4e4c5386e723cd37b4503f
166 Nc88ebbd61d3d4ac0be8d9e7b92d67247 rdf:first sg:person.0731511140.80
167 rdf:rest rdf:nil
168 Ncd92646886a24547aba5f39cca84d359 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Incidence
170 rdf:type schema:DefinedTerm
171 Nde68eba8323345f4b6466f37f3e5b4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name United States
173 rdf:type schema:DefinedTerm
174 Nf3f24519da5b447e8812b7a8306ff6b5 schema:issueNumber 5
175 rdf:type schema:PublicationIssue
176 Nfa0d4a4ad8594ee8b0efcb08a84e85ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Prospective Studies
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
183 schema:name Cardiorespiratory Medicine and Haematology
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
186 schema:name Paediatrics and Reproductive Medicine
187 rdf:type schema:DefinedTerm
188 sg:grant.2424028 http://pending.schema.org/fundedItem sg:pub.10.1203/00006450-200105000-00005
189 rdf:type schema:MonetaryGrant
190 sg:grant.2430540 http://pending.schema.org/fundedItem sg:pub.10.1203/00006450-200105000-00005
191 rdf:type schema:MonetaryGrant
192 sg:journal.1007352 schema:issn 0031-3998
193 1530-0447
194 schema:name Pediatric Research
195 schema:publisher Springer Nature
196 rdf:type schema:Periodical
197 sg:person.010210642437.54 schema:affiliation grid-institutes:None
198 schema:familyName Trefz
199 schema:givenName Friedrich
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010210642437.54
201 rdf:type schema:Person
202 sg:person.01023203544.00 schema:affiliation grid-institutes:grid.420089.7
203 schema:familyName De La Cruz
204 schema:givenName Felix
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023203544.00
206 rdf:type schema:Person
207 sg:person.01051643231.51 schema:affiliation grid-institutes:grid.38142.3c
208 schema:familyName Levy
209 schema:givenName Harvey L
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051643231.51
211 rdf:type schema:Person
212 sg:person.01137432144.34 schema:affiliation grid-institutes:grid.419352.8
213 schema:familyName Güttler
214 schema:givenName Flemming
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137432144.34
216 rdf:type schema:Person
217 sg:person.01165052376.46 schema:affiliation grid-institutes:grid.38142.3c
218 schema:familyName Allred
219 schema:givenName Elizabeth N
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165052376.46
221 rdf:type schema:Person
222 sg:person.01234205031.40 schema:affiliation grid-institutes:grid.176731.5
223 schema:familyName Rouse
224 schema:givenName Bobbye M
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234205031.40
226 rdf:type schema:Person
227 sg:person.0673364731.12 schema:affiliation grid-institutes:grid.42327.30
228 schema:familyName Hanley
229 schema:givenName William B
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673364731.12
231 rdf:type schema:Person
232 sg:person.0731511140.80 schema:affiliation grid-institutes:grid.239546.f
233 schema:familyName Koch
234 schema:givenName Richard
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731511140.80
236 rdf:type schema:Person
237 sg:person.0760021664.46 schema:affiliation grid-institutes:grid.419352.8
238 schema:familyName Guldberg
239 schema:givenName Per
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760021664.46
241 rdf:type schema:Person
242 sg:person.07664653317.72 schema:affiliation grid-institutes:grid.176731.5
243 schema:familyName Matalon
244 schema:givenName Reuben
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07664653317.72
246 rdf:type schema:Person
247 sg:person.0777624340.39 schema:affiliation grid-institutes:grid.239546.f
248 schema:familyName Azen
249 schema:givenName Colleen
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777624340.39
251 rdf:type schema:Person
252 sg:pub.10.1007/pl00014236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044214966
253 https://doi.org/10.1007/pl00014236
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/ng0398-266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026871339
256 https://doi.org/10.1038/ng0398-266
257 rdf:type schema:CreativeWork
258 sg:pub.10.1203/00006450-199707000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064211129
259 https://doi.org/10.1203/00006450-199707000-00016
260 rdf:type schema:CreativeWork
261 grid-institutes:None schema:alternateName Children’s Hospital of Reutlingen, Germany
262 schema:name Children’s Hospital of Reutlingen, Germany
263 rdf:type schema:Organization
264 grid-institutes:grid.176731.5 schema:alternateName University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A.
265 schema:name University of Texas Medical Branch at Galveston, Galveston, Texas, U.S.A.
266 rdf:type schema:Organization
267 grid-institutes:grid.239546.f schema:alternateName Children’s Hospital of Los Angeles, Los Angeles, California, U.S.A.
268 schema:name Children’s Hospital of Los Angeles, Los Angeles, California, U.S.A.
269 rdf:type schema:Organization
270 grid-institutes:grid.38142.3c schema:alternateName Division of Genetics and Neuroepidemiology Unit, Children’s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A.
271 schema:name Division of Genetics and Neuroepidemiology Unit, Children’s Hospital and Departments of Pediatrics and Neurology, Harvard Medical School, Boston, Massachusetts, U.S.A.
272 rdf:type schema:Organization
273 grid-institutes:grid.419352.8 schema:alternateName John F. Kennedy Institute, Glostrup, Denmark
274 schema:name John F. Kennedy Institute, Glostrup, Denmark
275 rdf:type schema:Organization
276 grid-institutes:grid.420089.7 schema:alternateName the National Institute of Child Health and Human Development, Bethesda, Maryland, U.S.A.
277 schema:name the National Institute of Child Health and Human Development, Bethesda, Maryland, U.S.A.
278 rdf:type schema:Organization
279 grid-institutes:grid.42327.30 schema:alternateName Hospital for Sick Children, Toronto, Ontario, Canada
280 schema:name Hospital for Sick Children, Toronto, Ontario, Canada
281 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...