Is Periventricular Leukomalacia an Axonopathy as Well as an Oligopathy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-04

AUTHORS

Olaf Dammann, Henrik Hagberg, Alan Leviton

ABSTRACT

Periventricular leukomalacia is a white matter disorder, the neonatal cranial ultrasound images of which predict long-term developmental limitations among preterm infants. The vulnerability of oligodendrocytes has led to the hypothesis that oligodendrocytes suffer the primary damage, with axonal damage occurring as a consequence. In this article, we discuss the differential role of oligodendrocytes and axons in this disorder's etiology, offering analogies from the multiple sclerosis and hydrocephalus literature. We conclude that it is too early to view periventricular leukomalacia exclusively as a consequence of oligodendrocyte damage and/or maldevelopment. More... »

PAGES

pr200171

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-200104000-00003

DOI

http://dx.doi.org/10.1203/00006450-200104000-00003

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026015589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11264425


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