The Role of Recombinant Platelet-Activating Factor Acetylhydrolase in a Neonatal Rat Model of Necrotizing Enterocolitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-12

AUTHORS

Michael S Caplan, Matthew Lickerman, Luba Adler, Gregory N Dietsch, Albert Yu

ABSTRACT

Previous studies have shown that the endogenous inflammatory mediator platelet-activating factor (PAF) plays an important role in the pathophysiology of neonatal necrotizing enterocolitis (NEC). This study was designed to investigate the role of the PAF-degrading enzyme acetylhydrolase (PAF-AH) in a neonatal rat model of NEC. To study the absorption, localization, and activity of human recombinant PAF-AH (rPAF-AH), newborn rats were treated with enteral rPAF-AH, and plasma and intestines were sampled at 8 and 24 h for determination of PAF-AH enzyme activity and rPAF-AH concentration using a specific enzyme-linked immunoassay. To study the effect of rPAF-AH on neonatal NEC, rats were treated with rPAF-AH via the enteral route every 3 h, and then subjected to formula feeding and asphyxia per an established neonatal rat protocol for NEC. Pretreatment with enteral rPAF-AH significantly reduced the incidence of NEC compared with controls (6/26 versus 19/26, p < 0.001). We found that enteral rPAF-AH administration resulted in significant intestinal PAF-AH activity but no circulating PAF-AH activity despite immunohistochemical localization of the administered rPAF-AH to the intestinal epithelial cells. These findings suggest that rPAF-AH is functional and stable in the gut of neonatal rats. We conclude that enteral administration of rPAF-AH remains locally active and reduces the incidence of NEC in our experimental animal model. More... »

PAGES

779

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199712000-00010

DOI

http://dx.doi.org/10.1203/00006450-199712000-00010

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1064211424

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9396557


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "1-Alkyl-2-acetylglycerophosphocholine Esterase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterocolitis, Pseudomembranous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phospholipases A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Pediatrics, Evanston Hospital, Northwestern University Medical School, Evanston, Illinois 60201"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caplan", 
        "givenName": "Michael S", 
        "id": "sg:person.01262122774.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262122774.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Pediatrics, Evanston Hospital, Northwestern University Medical School, Evanston, Illinois 60201"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lickerman", 
        "givenName": "Matthew", 
        "id": "sg:person.01076016023.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076016023.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Department of Pediatrics, Evanston Hospital, Northwestern University Medical School, Evanston, Illinois 60201"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adler", 
        "givenName": "Luba", 
        "id": "sg:person.01027702623.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027702623.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417540.3", 
          "name": [
            "ICOS Corporation, Bothell, Washington 98021"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dietsch", 
        "givenName": "Gregory N", 
        "id": "sg:person.01133261677.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133261677.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (United States)", 
          "id": "https://www.grid.ac/institutes/grid.417540.3", 
          "name": [
            "ICOS Corporation, Bothell, Washington 98021"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Albert", 
        "id": "sg:person.01313330025.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313330025.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0022-3468(74)90093-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001326157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-197708000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001327102", 
          "https://doi.org/10.1203/00006450-197708000-00011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199308000-00027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007065895", 
          "https://doi.org/10.1203/00006450-199308000-00027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199408000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020697628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199408000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020697628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199408000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020697628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01297031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021403920", 
          "https://doi.org/10.1007/bf01297031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01297031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021403920", 
          "https://doi.org/10.1007/bf01297031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15513819409037698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021488695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)93304-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023338008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)93304-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023338008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(05)82418-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023917858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/15513819309048223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030188152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(90)90616-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032734620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-6980(90)90030-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034907671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.55.070186.002411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036028547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/374549a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038734170", 
          "https://doi.org/10.1038/374549a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113459", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039378936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/377435a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040863276", 
          "https://doi.org/10.1038/377435a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-3476(05)80661-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041534970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049514717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199703000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060200315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199703000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060200315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005176-199703000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060200315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.1991.260.6.g965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077189274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(90)91158-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078478666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1990.259.5.c697", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078530861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079545593", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.1.5.3678700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079892469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081867555", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081997440", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-12", 
    "datePublishedReg": "1997-12-01", 
    "description": "Previous studies have shown that the endogenous inflammatory mediator platelet-activating factor (PAF) plays an important role in the pathophysiology of neonatal necrotizing enterocolitis (NEC). This study was designed to investigate the role of the PAF-degrading enzyme acetylhydrolase (PAF-AH) in a neonatal rat model of NEC. To study the absorption, localization, and activity of human recombinant PAF-AH (rPAF-AH), newborn rats were treated with enteral rPAF-AH, and plasma and intestines were sampled at 8 and 24 h for determination of PAF-AH enzyme activity and rPAF-AH concentration using a specific enzyme-linked immunoassay. To study the effect of rPAF-AH on neonatal NEC, rats were treated with rPAF-AH via the enteral route every 3 h, and then subjected to formula feeding and asphyxia per an established neonatal rat protocol for NEC. Pretreatment with enteral rPAF-AH significantly reduced the incidence of NEC compared with controls (6/26 versus 19/26, p < 0.001). We found that enteral rPAF-AH administration resulted in significant intestinal PAF-AH activity but no circulating PAF-AH activity despite immunohistochemical localization of the administered rPAF-AH to the intestinal epithelial cells. These findings suggest that rPAF-AH is functional and stable in the gut of neonatal rats. We conclude that enteral administration of rPAF-AH remains locally active and reduces the incidence of NEC in our experimental animal model.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1203/00006450-199712000-00010", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2412866", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "The Role of Recombinant Platelet-Activating Factor Acetylhydrolase in a Neonatal Rat Model of Necrotizing Enterocolitis", 
    "pagination": "779", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4c90947af248d5d6f008240327e818bcf8cbd0835892e6ea4306d8f087889191"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9396557"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-199712000-00010"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1064211424"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-199712000-00010", 
      "https://app.dimensions.ai/details/publication/pub.1064211424"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pr19972571"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-199712000-00010'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-199712000-00010'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-199712000-00010'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-199712000-00010'


 

This table displays all metadata directly associated to this object as RDF triples.

223 TRIPLES      21 PREDICATES      65 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-199712000-00010 schema:about N1557671a9a3c40fcba22282ced3a96ed
2 N17998186b25348429f558669edde1a27
3 N1a302a9a1f624a5cb77f1f5cfcd2d3bf
4 N238d1a9e68c7431093a2285069525962
5 N369c0fe704cc41afb60c0d178272ad01
6 N62a5c9a598d14f63a4a6a5fbac6db31a
7 N766004d2387a4442ac82aea5e7db96d7
8 N77efde758e1f494ab2fbf46d0be2a1fe
9 Na2693abe5fa3436497984ca6875e50c4
10 Nae45775a000947d99fbf11b705c99270
11 Nc7af53f861ea4c97ba29d318881b613f
12 anzsrc-for:11
13 anzsrc-for:1109
14 schema:author Nc07f7435a8d04cd19ed38beed4851ad2
15 schema:citation sg:pub.10.1007/bf01297031
16 sg:pub.10.1038/374549a0
17 sg:pub.10.1038/377435a0
18 sg:pub.10.1203/00006450-197708000-00011
19 sg:pub.10.1203/00006450-199308000-00027
20 https://app.dimensions.ai/details/publication/pub.1079545593
21 https://app.dimensions.ai/details/publication/pub.1081867555
22 https://app.dimensions.ai/details/publication/pub.1081997440
23 https://doi.org/10.1016/0016-5085(90)90616-9
24 https://doi.org/10.1016/0016-5085(90)91158-3
25 https://doi.org/10.1016/0022-3468(74)90093-1
26 https://doi.org/10.1016/0090-6980(90)90030-y
27 https://doi.org/10.1016/0140-6736(90)93304-8
28 https://doi.org/10.1016/s0022-3476(05)80661-4
29 https://doi.org/10.1016/s0022-3476(05)82418-7
30 https://doi.org/10.1096/fasebj.1.5.3678700
31 https://doi.org/10.1097/00005176-199408000-00015
32 https://doi.org/10.1097/00005176-199703000-00012
33 https://doi.org/10.1146/annurev.bi.55.070186.002411
34 https://doi.org/10.1152/ajpcell.1990.259.5.c697
35 https://doi.org/10.1152/ajpgi.1991.260.6.g965
36 https://doi.org/10.1172/jci113459
37 https://doi.org/10.1172/jci115900
38 https://doi.org/10.3109/15513819309048223
39 https://doi.org/10.3109/15513819409037698
40 schema:datePublished 1997-12
41 schema:datePublishedReg 1997-12-01
42 schema:description Previous studies have shown that the endogenous inflammatory mediator platelet-activating factor (PAF) plays an important role in the pathophysiology of neonatal necrotizing enterocolitis (NEC). This study was designed to investigate the role of the PAF-degrading enzyme acetylhydrolase (PAF-AH) in a neonatal rat model of NEC. To study the absorption, localization, and activity of human recombinant PAF-AH (rPAF-AH), newborn rats were treated with enteral rPAF-AH, and plasma and intestines were sampled at 8 and 24 h for determination of PAF-AH enzyme activity and rPAF-AH concentration using a specific enzyme-linked immunoassay. To study the effect of rPAF-AH on neonatal NEC, rats were treated with rPAF-AH via the enteral route every 3 h, and then subjected to formula feeding and asphyxia per an established neonatal rat protocol for NEC. Pretreatment with enteral rPAF-AH significantly reduced the incidence of NEC compared with controls (6/26 versus 19/26, p < 0.001). We found that enteral rPAF-AH administration resulted in significant intestinal PAF-AH activity but no circulating PAF-AH activity despite immunohistochemical localization of the administered rPAF-AH to the intestinal epithelial cells. These findings suggest that rPAF-AH is functional and stable in the gut of neonatal rats. We conclude that enteral administration of rPAF-AH remains locally active and reduces the incidence of NEC in our experimental animal model.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N50c347c1c73045abbef130f99d9e3940
47 N73cacdcc81b347e4a0a01ae1fdb38bcf
48 sg:journal.1007352
49 schema:name The Role of Recombinant Platelet-Activating Factor Acetylhydrolase in a Neonatal Rat Model of Necrotizing Enterocolitis
50 schema:pagination 779
51 schema:productId N159c06836f954e49ae17d2a7d4abcf2b
52 N62d369f1d39e4d02a2ba036118f6be6f
53 N62d49a161caa4ec79893c6e6cdb48679
54 Nb0c4df3f541a4d109d6896de85c2740f
55 Nbc3af301cc664e06af278dedd8525b6c
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064211424
57 https://doi.org/10.1203/00006450-199712000-00010
58 schema:sdDatePublished 2019-04-10T14:47
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N048031473feb476f9ddc41d288e5b7f9
61 schema:url https://www.nature.com/articles/pr19972571
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N048031473feb476f9ddc41d288e5b7f9 schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N1557671a9a3c40fcba22282ced3a96ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Recombinant Proteins
69 rdf:type schema:DefinedTerm
70 N159c06836f954e49ae17d2a7d4abcf2b schema:name nlm_unique_id
71 schema:value 0100714
72 rdf:type schema:PropertyValue
73 N17998186b25348429f558669edde1a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Animals
75 rdf:type schema:DefinedTerm
76 N1a302a9a1f624a5cb77f1f5cfcd2d3bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Enterocolitis, Pseudomembranous
78 rdf:type schema:DefinedTerm
79 N238d1a9e68c7431093a2285069525962 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Humans
81 rdf:type schema:DefinedTerm
82 N24fc488efbd142d496bbadab0523d5ca rdf:first sg:person.01313330025.37
83 rdf:rest rdf:nil
84 N369c0fe704cc41afb60c0d178272ad01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Animals, Newborn
86 rdf:type schema:DefinedTerm
87 N50c347c1c73045abbef130f99d9e3940 schema:issueNumber 6
88 rdf:type schema:PublicationIssue
89 N5a5e2c7b9d0449a6a27d1202335880ac rdf:first sg:person.01027702623.55
90 rdf:rest Nc96708c36e034d04af2138b33e7a3fd3
91 N62a5c9a598d14f63a4a6a5fbac6db31a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name 1-Alkyl-2-acetylglycerophosphocholine Esterase
93 rdf:type schema:DefinedTerm
94 N62d369f1d39e4d02a2ba036118f6be6f schema:name readcube_id
95 schema:value 4c90947af248d5d6f008240327e818bcf8cbd0835892e6ea4306d8f087889191
96 rdf:type schema:PropertyValue
97 N62d49a161caa4ec79893c6e6cdb48679 schema:name pubmed_id
98 schema:value 9396557
99 rdf:type schema:PropertyValue
100 N73cacdcc81b347e4a0a01ae1fdb38bcf schema:volumeNumber 42
101 rdf:type schema:PublicationVolume
102 N766004d2387a4442ac82aea5e7db96d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Disease Models, Animal
104 rdf:type schema:DefinedTerm
105 N77efde758e1f494ab2fbf46d0be2a1fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Immunohistochemistry
107 rdf:type schema:DefinedTerm
108 Na2693abe5fa3436497984ca6875e50c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Rats, Sprague-Dawley
110 rdf:type schema:DefinedTerm
111 Nae45775a000947d99fbf11b705c99270 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Rats
113 rdf:type schema:DefinedTerm
114 Nb0c4df3f541a4d109d6896de85c2740f schema:name doi
115 schema:value 10.1203/00006450-199712000-00010
116 rdf:type schema:PropertyValue
117 Nbc3af301cc664e06af278dedd8525b6c schema:name dimensions_id
118 schema:value pub.1064211424
119 rdf:type schema:PropertyValue
120 Nc07f7435a8d04cd19ed38beed4851ad2 rdf:first sg:person.01262122774.45
121 rdf:rest Nd0d70b7881634578b985c62e9e839bac
122 Nc7af53f861ea4c97ba29d318881b613f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Phospholipases A
124 rdf:type schema:DefinedTerm
125 Nc96708c36e034d04af2138b33e7a3fd3 rdf:first sg:person.01133261677.24
126 rdf:rest N24fc488efbd142d496bbadab0523d5ca
127 Nd0d70b7881634578b985c62e9e839bac rdf:first sg:person.01076016023.35
128 rdf:rest N5a5e2c7b9d0449a6a27d1202335880ac
129 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
130 schema:name Medical and Health Sciences
131 rdf:type schema:DefinedTerm
132 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
133 schema:name Neurosciences
134 rdf:type schema:DefinedTerm
135 sg:grant.2412866 http://pending.schema.org/fundedItem sg:pub.10.1203/00006450-199712000-00010
136 rdf:type schema:MonetaryGrant
137 sg:journal.1007352 schema:issn 0031-3998
138 1530-0447
139 schema:name Pediatric Research
140 rdf:type schema:Periodical
141 sg:person.01027702623.55 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
142 schema:familyName Adler
143 schema:givenName Luba
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027702623.55
145 rdf:type schema:Person
146 sg:person.01076016023.35 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
147 schema:familyName Lickerman
148 schema:givenName Matthew
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076016023.35
150 rdf:type schema:Person
151 sg:person.01133261677.24 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
152 schema:familyName Dietsch
153 schema:givenName Gregory N
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133261677.24
155 rdf:type schema:Person
156 sg:person.01262122774.45 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
157 schema:familyName Caplan
158 schema:givenName Michael S
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262122774.45
160 rdf:type schema:Person
161 sg:person.01313330025.37 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
162 schema:familyName Yu
163 schema:givenName Albert
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313330025.37
165 rdf:type schema:Person
166 sg:pub.10.1007/bf01297031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403920
167 https://doi.org/10.1007/bf01297031
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/374549a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038734170
170 https://doi.org/10.1038/374549a0
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/377435a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040863276
173 https://doi.org/10.1038/377435a0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1203/00006450-197708000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001327102
176 https://doi.org/10.1203/00006450-197708000-00011
177 rdf:type schema:CreativeWork
178 sg:pub.10.1203/00006450-199308000-00027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007065895
179 https://doi.org/10.1203/00006450-199308000-00027
180 rdf:type schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1079545593 schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1081867555 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1081997440 schema:CreativeWork
184 https://doi.org/10.1016/0016-5085(90)90616-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032734620
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/0016-5085(90)91158-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078478666
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0022-3468(74)90093-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001326157
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0090-6980(90)90030-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034907671
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0140-6736(90)93304-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023338008
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0022-3476(05)80661-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041534970
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0022-3476(05)82418-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023917858
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1096/fasebj.1.5.3678700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079892469
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/00005176-199408000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020697628
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00005176-199703000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060200315
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1146/annurev.bi.55.070186.002411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036028547
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1152/ajpcell.1990.259.5.c697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078530861
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1152/ajpgi.1991.260.6.g965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077189274
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1172/jci113459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039378936
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1172/jci115900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049514717
213 rdf:type schema:CreativeWork
214 https://doi.org/10.3109/15513819309048223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030188152
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3109/15513819409037698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021488695
217 rdf:type schema:CreativeWork
218 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
219 schema:name Department of Pediatrics, Evanston Hospital, Northwestern University Medical School, Evanston, Illinois 60201
220 rdf:type schema:Organization
221 https://www.grid.ac/institutes/grid.417540.3 schema:alternateName Eli Lilly (United States)
222 schema:name ICOS Corporation, Bothell, Washington 98021
223 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...