Cerebral Glucose Metabolism Is Decreased in White Matter Changes in Patients with Phenylketonuria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-07

AUTHORS

Steen Hasselbalch, Gitte M Knudsen, Peter B Toft, Peter Høgh, Enrico Tedeschi, Søren Holm, Charlotte Videbæk, Ole Henriksen, Hans C Lou, Olaf B Paulson

ABSTRACT

Cerebral magnetic resonance imaging (MRI) has revealed white matter changes in patients with phenylketonuria (PKU), an inborn error of metabolism with increased plasma phenylalanine level. Because the significance of these lesions is unknown, this study was undertaken to determine whether glucose metabolism was depressed in cerebral white matter MRI changes in patients with PKU. Four patients with PKU and nine healthy volunteers with an average age of 23 y (range 19-26 y) and 23 y (range 20-27 y), respectively, were studied. The IQ of patients with PKU was between 58 and 97. Cerebral MRI and positron emission tomography images with 18F-deoxyglucose were obtained, and arteriovenous differences for oxygen and glucose as well as cerebral blood flow was measured simultaneously to determine global cerebral oxygen and glucose metabolism. Cerebral MRI revealed that all patients with PKU had white matter changes with characteristic localization. In patients with PKU, regional glucose metabolism was 36% lower in the anterior periventricular areas, 0.14 +/- 0.06 compared with 0.22 +/- 0.04 mumol.g-1.min-1 in controls (mean +/- SD, p < 0.05, Mann-Whitney). Further, the ratio between glucose metabolism in the affected white matter and the cortex was 14% lower in the patients, decreasing from 0.57 +/- 0.05 to 0.48 +/- 0.06 (p < 0.05). Global cerebral blood flow, oxygen and glucose consumption were similar in the two groups. In conclusion, regional glucose metabolism is lower in MRI-demonstrated white matter changes. In mildly intellectually impaired patients with PKU, global cerebral glucose and oxygen metabolism remain intact. More... »

PAGES

21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004

DOI

http://dx.doi.org/10.1203/00006450-199607000-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1064208454

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8798240


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