Cerebral Glucose Metabolism Is Decreased in White Matter Changes in Patients with Phenylketonuria View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-07

AUTHORS

Steen Hasselbalch, Gitte M Knudsen, Peter B Toft, Peter Høgh, Enrico Tedeschi, Søren Holm, Charlotte Videbæk, Ole Henriksen, Hans C Lou, Olaf B Paulson

ABSTRACT

Cerebral magnetic resonance imaging (MRI) has revealed white matter changes in patients with phenylketonuria (PKU), an inborn error of metabolism with increased plasma phenylalanine level. Because the significance of these lesions is unknown, this study was undertaken to determine whether glucose metabolism was depressed in cerebral white matter MRI changes in patients with PKU. Four patients with PKU and nine healthy volunteers with an average age of 23 y (range 19-26 y) and 23 y (range 20-27 y), respectively, were studied. The IQ of patients with PKU was between 58 and 97. Cerebral MRI and positron emission tomography images with 18F-deoxyglucose were obtained, and arteriovenous differences for oxygen and glucose as well as cerebral blood flow was measured simultaneously to determine global cerebral oxygen and glucose metabolism. Cerebral MRI revealed that all patients with PKU had white matter changes with characteristic localization. In patients with PKU, regional glucose metabolism was 36% lower in the anterior periventricular areas, 0.14 +/- 0.06 compared with 0.22 +/- 0.04 mumol.g-1.min-1 in controls (mean +/- SD, p < 0.05, Mann-Whitney). Further, the ratio between glucose metabolism in the affected white matter and the cortex was 14% lower in the patients, decreasing from 0.57 +/- 0.05 to 0.48 +/- 0.06 (p < 0.05). Global cerebral blood flow, oxygen and glucose consumption were similar in the two groups. In conclusion, regional glucose metabolism is lower in MRI-demonstrated white matter changes. In mildly intellectually impaired patients with PKU, global cerebral glucose and oxygen metabolism remain intact. More... »

PAGES

21

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004

DOI

http://dx.doi.org/10.1203/00006450-199607000-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1064208454

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8798240


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylketonurias", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasselbalch", 
        "givenName": "Steen", 
        "id": "sg:person.0632617733.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632617733.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Knudsen", 
        "givenName": "Gitte M", 
        "id": "sg:person.013164351720.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164351720.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kennedy Center", 
          "id": "https://www.grid.ac/institutes/grid.419352.8", 
          "name": [
            "John F. Kennedy Institute, DK-2600 Glostrup, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toft", 
        "givenName": "Peter B", 
        "id": "sg:person.011541215614.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011541215614.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00f8gh", 
        "givenName": "Peter", 
        "id": "sg:person.01205331277.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205331277.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tedeschi", 
        "givenName": "Enrico", 
        "id": "sg:person.01170754374.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170754374.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holm", 
        "givenName": "S\u00f8ren", 
        "id": "sg:person.0740340304.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740340304.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Videb\u00e6k", 
        "givenName": "Charlotte", 
        "id": "sg:person.0630672741.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630672741.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hvidovre Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411905.8", 
          "name": [
            "John F. Kennedy Institute, DK-2600 Glostrup and the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henriksen", 
        "givenName": "Ole", 
        "id": "sg:person.01233030152.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233030152.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kennedy Center", 
          "id": "https://www.grid.ac/institutes/grid.419352.8", 
          "name": [
            "John F. Kennedy Institute, DK-2600 Glostrup, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lou", 
        "givenName": "Hans C", 
        "id": "sg:person.01120141024.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120141024.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paulson", 
        "givenName": "Olaf B", 
        "id": "sg:person.01244010503.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244010503.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/mrm.1910310108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001259307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)90573-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(92)90573-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199502000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008611054", 
          "https://doi.org/10.1203/00006450-199502000-00020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)93401-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012400542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(90)93401-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012400542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1977.tb10649.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016554520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1991.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031278026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.1991.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031278026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02436753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032471405", 
          "https://doi.org/10.1007/bf02436753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01963563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846199", 
          "https://doi.org/10.1007/bf01963563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01963563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846199", 
          "https://doi.org/10.1007/bf01963563"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01800008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035422753", 
          "https://doi.org/10.1007/bf01800008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf01800008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035422753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(85)90250-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(85)90250-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037612994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01616412.1986.11739761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058295574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/116.4.811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059439199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1109/tns.1984.4333335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1061729141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082137871", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082637766", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-07", 
    "datePublishedReg": "1996-07-01", 
    "description": "Cerebral magnetic resonance imaging (MRI) has revealed white matter changes in patients with phenylketonuria (PKU), an inborn error of metabolism with increased plasma phenylalanine level. Because the significance of these lesions is unknown, this study was undertaken to determine whether glucose metabolism was depressed in cerebral white matter MRI changes in patients with PKU. Four patients with PKU and nine healthy volunteers with an average age of 23 y (range 19-26 y) and 23 y (range 20-27 y), respectively, were studied. The IQ of patients with PKU was between 58 and 97. Cerebral MRI and positron emission tomography images with 18F-deoxyglucose were obtained, and arteriovenous differences for oxygen and glucose as well as cerebral blood flow was measured simultaneously to determine global cerebral oxygen and glucose metabolism. Cerebral MRI revealed that all patients with PKU had white matter changes with characteristic localization. In patients with PKU, regional glucose metabolism was 36% lower in the anterior periventricular areas, 0.14 +/- 0.06 compared with 0.22 +/- 0.04 mumol.g-1.min-1 in controls (mean +/- SD, p < 0.05, Mann-Whitney). Further, the ratio between glucose metabolism in the affected white matter and the cortex was 14% lower in the patients, decreasing from 0.57 +/- 0.05 to 0.48 +/- 0.06 (p < 0.05). Global cerebral blood flow, oxygen and glucose consumption were similar in the two groups. In conclusion, regional glucose metabolism is lower in MRI-demonstrated white matter changes. In mildly intellectually impaired patients with PKU, global cerebral glucose and oxygen metabolism remain intact.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1203/00006450-199607000-00004", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Cerebral Glucose Metabolism Is Decreased in White Matter Changes in Patients with Phenylketonuria", 
    "pagination": "21", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fad92c55403ad3b56cfd7f96b8ee7941952e359e6d318998b2c1a27f4c0513ba"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8798240"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-199607000-00004"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1064208454"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-199607000-00004", 
      "https://app.dimensions.ai/details/publication/pub.1064208454"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000427.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pr19962582"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-199607000-00004'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      21 PREDICATES      54 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-199607000-00004 schema:about N0a3b2df0a9bf486982d0ac00a03717dc
2 N0e8e038967af4eb8be59d942fce18cad
3 N1abc99010c534251ab9948ee8f7e0bf6
4 N38ce879da4cf49abb7345d2bba9d6536
5 N722a9bcc81364c4f8bd9df84580ef1ec
6 Nd5b264b601e94aa5a667e378b3cf27fe
7 Ndfc2fdf479714808b94f703462913afe
8 Ne62a3327f6d94f30a915f928f0e00237
9 Nea5738cbd23047e9b6d1d2493e324b82
10 anzsrc-for:11
11 anzsrc-for:1103
12 schema:author N04f9d3e31a0740be83a7e24cbdccff5c
13 schema:citation sg:pub.10.1007/bf01800008
14 sg:pub.10.1007/bf01963563
15 sg:pub.10.1007/bf02436753
16 sg:pub.10.1203/00006450-199502000-00020
17 https://app.dimensions.ai/details/publication/pub.1082137871
18 https://app.dimensions.ai/details/publication/pub.1082637766
19 https://doi.org/10.1002/mrm.1910310108
20 https://doi.org/10.1007/bf01800008
21 https://doi.org/10.1016/0006-8993(92)90573-r
22 https://doi.org/10.1016/0140-6736(90)93401-a
23 https://doi.org/10.1016/s0140-6736(85)90250-8
24 https://doi.org/10.1038/jcbfm.1991.95
25 https://doi.org/10.1080/01616412.1986.11739761
26 https://doi.org/10.1093/brain/116.4.811
27 https://doi.org/10.1109/tns.1984.4333335
28 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x
29 schema:datePublished 1996-07
30 schema:datePublishedReg 1996-07-01
31 schema:description Cerebral magnetic resonance imaging (MRI) has revealed white matter changes in patients with phenylketonuria (PKU), an inborn error of metabolism with increased plasma phenylalanine level. Because the significance of these lesions is unknown, this study was undertaken to determine whether glucose metabolism was depressed in cerebral white matter MRI changes in patients with PKU. Four patients with PKU and nine healthy volunteers with an average age of 23 y (range 19-26 y) and 23 y (range 20-27 y), respectively, were studied. The IQ of patients with PKU was between 58 and 97. Cerebral MRI and positron emission tomography images with 18F-deoxyglucose were obtained, and arteriovenous differences for oxygen and glucose as well as cerebral blood flow was measured simultaneously to determine global cerebral oxygen and glucose metabolism. Cerebral MRI revealed that all patients with PKU had white matter changes with characteristic localization. In patients with PKU, regional glucose metabolism was 36% lower in the anterior periventricular areas, 0.14 +/- 0.06 compared with 0.22 +/- 0.04 mumol.g-1.min-1 in controls (mean +/- SD, p < 0.05, Mann-Whitney). Further, the ratio between glucose metabolism in the affected white matter and the cortex was 14% lower in the patients, decreasing from 0.57 +/- 0.05 to 0.48 +/- 0.06 (p < 0.05). Global cerebral blood flow, oxygen and glucose consumption were similar in the two groups. In conclusion, regional glucose metabolism is lower in MRI-demonstrated white matter changes. In mildly intellectually impaired patients with PKU, global cerebral glucose and oxygen metabolism remain intact.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N85c5f1af86a445f2ad2639fd765ffd38
36 N89814ccfb533450d941f470c0c38a9e2
37 sg:journal.1007352
38 schema:name Cerebral Glucose Metabolism Is Decreased in White Matter Changes in Patients with Phenylketonuria
39 schema:pagination 21
40 schema:productId N1e9390629e344b069e4dbfb2a656bae3
41 N67be45aad5fa47f89cae380b4c73b2d0
42 N6a5d4915ec8545dc9fd56152ce41fd70
43 N709c250b99f242f68a8480a54b3b7b9b
44 Nc5877ede0795482c87b5a001aa8bd2b5
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064208454
46 https://doi.org/10.1203/00006450-199607000-00004
47 schema:sdDatePublished 2019-04-10T20:35
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher Nae5bf16c4fc04789ad1553e2d030d75a
50 schema:url https://www.nature.com/articles/pr19962582
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N04f9d3e31a0740be83a7e24cbdccff5c rdf:first sg:person.0632617733.37
55 rdf:rest N642d87d7b8fb4bad8ac31c39609a1349
56 N0a3b2df0a9bf486982d0ac00a03717dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Case-Control Studies
58 rdf:type schema:DefinedTerm
59 N0e8e038967af4eb8be59d942fce18cad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Glucose
61 rdf:type schema:DefinedTerm
62 N1abc99010c534251ab9948ee8f7e0bf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Magnetic Resonance Imaging
64 rdf:type schema:DefinedTerm
65 N1e9390629e344b069e4dbfb2a656bae3 schema:name pubmed_id
66 schema:value 8798240
67 rdf:type schema:PropertyValue
68 N1f78fa7fe88e498e831989db5953891c rdf:first sg:person.01170754374.38
69 rdf:rest N870fe684ab5443edb97dd829d83dc1f9
70 N25ae4dc9c6d64512b6ad217d46a7544d rdf:first sg:person.01233030152.30
71 rdf:rest N2c0d7b78e0a14bcf9f09fb691489ed69
72 N2c0d7b78e0a14bcf9f09fb691489ed69 rdf:first sg:person.01120141024.34
73 rdf:rest Ncfcfce64110d4684a64b4853d35fa686
74 N38ce879da4cf49abb7345d2bba9d6536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Male
76 rdf:type schema:DefinedTerm
77 N632c7554f36f4d95bd3529235cb3bdc6 rdf:first sg:person.0630672741.04
78 rdf:rest N25ae4dc9c6d64512b6ad217d46a7544d
79 N642d87d7b8fb4bad8ac31c39609a1349 rdf:first sg:person.013164351720.45
80 rdf:rest Nf1a3f353006c47a8bd87731fc27079a5
81 N67be45aad5fa47f89cae380b4c73b2d0 schema:name dimensions_id
82 schema:value pub.1064208454
83 rdf:type schema:PropertyValue
84 N6a5d4915ec8545dc9fd56152ce41fd70 schema:name doi
85 schema:value 10.1203/00006450-199607000-00004
86 rdf:type schema:PropertyValue
87 N709c250b99f242f68a8480a54b3b7b9b schema:name readcube_id
88 schema:value fad92c55403ad3b56cfd7f96b8ee7941952e359e6d318998b2c1a27f4c0513ba
89 rdf:type schema:PropertyValue
90 N722a9bcc81364c4f8bd9df84580ef1ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Phenylketonurias
92 rdf:type schema:DefinedTerm
93 N85c5f1af86a445f2ad2639fd765ffd38 schema:volumeNumber 40
94 rdf:type schema:PublicationVolume
95 N870fe684ab5443edb97dd829d83dc1f9 rdf:first sg:person.0740340304.66
96 rdf:rest N632c7554f36f4d95bd3529235cb3bdc6
97 N89814ccfb533450d941f470c0c38a9e2 schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N9ac14ec79b644b45b8e3260fa30c3174 rdf:first sg:person.01205331277.16
100 rdf:rest N1f78fa7fe88e498e831989db5953891c
101 Nae5bf16c4fc04789ad1553e2d030d75a schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 Nc5877ede0795482c87b5a001aa8bd2b5 schema:name nlm_unique_id
104 schema:value 0100714
105 rdf:type schema:PropertyValue
106 Ncfcfce64110d4684a64b4853d35fa686 rdf:first sg:person.01244010503.37
107 rdf:rest rdf:nil
108 Nd5b264b601e94aa5a667e378b3cf27fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Humans
110 rdf:type schema:DefinedTerm
111 Ndfc2fdf479714808b94f703462913afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Female
113 rdf:type schema:DefinedTerm
114 Ne62a3327f6d94f30a915f928f0e00237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Brain
116 rdf:type schema:DefinedTerm
117 Nea5738cbd23047e9b6d1d2493e324b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adult
119 rdf:type schema:DefinedTerm
120 Nf1a3f353006c47a8bd87731fc27079a5 rdf:first sg:person.011541215614.40
121 rdf:rest N9ac14ec79b644b45b8e3260fa30c3174
122 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
123 schema:name Medical and Health Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
126 schema:name Clinical Sciences
127 rdf:type schema:DefinedTerm
128 sg:journal.1007352 schema:issn 0031-3998
129 1530-0447
130 schema:name Pediatric Research
131 rdf:type schema:Periodical
132 sg:person.01120141024.34 schema:affiliation https://www.grid.ac/institutes/grid.419352.8
133 schema:familyName Lou
134 schema:givenName Hans C
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120141024.34
136 rdf:type schema:Person
137 sg:person.011541215614.40 schema:affiliation https://www.grid.ac/institutes/grid.419352.8
138 schema:familyName Toft
139 schema:givenName Peter B
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011541215614.40
141 rdf:type schema:Person
142 sg:person.01170754374.38 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
143 schema:familyName Tedeschi
144 schema:givenName Enrico
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170754374.38
146 rdf:type schema:Person
147 sg:person.01205331277.16 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
148 schema:familyName Høgh
149 schema:givenName Peter
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205331277.16
151 rdf:type schema:Person
152 sg:person.01233030152.30 schema:affiliation https://www.grid.ac/institutes/grid.411905.8
153 schema:familyName Henriksen
154 schema:givenName Ole
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233030152.30
156 rdf:type schema:Person
157 sg:person.01244010503.37 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
158 schema:familyName Paulson
159 schema:givenName Olaf B
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244010503.37
161 rdf:type schema:Person
162 sg:person.013164351720.45 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
163 schema:familyName Knudsen
164 schema:givenName Gitte M
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013164351720.45
166 rdf:type schema:Person
167 sg:person.0630672741.04 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
168 schema:familyName Videbæk
169 schema:givenName Charlotte
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630672741.04
171 rdf:type schema:Person
172 sg:person.0632617733.37 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
173 schema:familyName Hasselbalch
174 schema:givenName Steen
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632617733.37
176 rdf:type schema:Person
177 sg:person.0740340304.66 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
178 schema:familyName Holm
179 schema:givenName Søren
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740340304.66
181 rdf:type schema:Person
182 sg:pub.10.1007/bf01800008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035422753
183 https://doi.org/10.1007/bf01800008
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/bf01963563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846199
186 https://doi.org/10.1007/bf01963563
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/bf02436753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032471405
189 https://doi.org/10.1007/bf02436753
190 rdf:type schema:CreativeWork
191 sg:pub.10.1203/00006450-199502000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008611054
192 https://doi.org/10.1203/00006450-199502000-00020
193 rdf:type schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1082137871 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1082637766 schema:CreativeWork
196 https://doi.org/10.1002/mrm.1910310108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001259307
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1007/bf01800008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035422753
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0006-8993(92)90573-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907087
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/0140-6736(90)93401-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1012400542
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s0140-6736(85)90250-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037612994
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1038/jcbfm.1991.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031278026
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1080/01616412.1986.11739761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058295574
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/brain/116.4.811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059439199
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1109/tns.1984.4333335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1061729141
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1111/j.1471-4159.1977.tb10649.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016554520
215 rdf:type schema:CreativeWork
216 https://www.grid.ac/institutes/grid.411905.8 schema:alternateName Hvidovre Hospital
217 schema:name John F. Kennedy Institute, DK-2600 Glostrup and the Danish Research Center of Magnetic Resonance, Hvidovre University Hospital, DK-2650 Hvidovre, Denmark
218 rdf:type schema:Organization
219 https://www.grid.ac/institutes/grid.419352.8 schema:alternateName Kennedy Center
220 schema:name John F. Kennedy Institute, DK-2600 Glostrup, Denmark
221 rdf:type schema:Organization
222 https://www.grid.ac/institutes/grid.475435.4 schema:alternateName Rigshospitalet
223 schema:name Department of Neurology, State University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...