Regional Metabolic Assessment of Human Brain during Development by Proton Magnetic Resonance Spectroscopy In Vivo and by High-Performance Liquid Chromatography/Gas ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-02

AUTHORS

Petra S Hüppi, Christoph Fusch, Chris Boesch, Roland Burri, Emilio Bossi, Maurizio Amato, Norbert Herschkowitz

ABSTRACT

To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myoinositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and compared in vivo established spectroscopic data with classic chromatographic data (HPLC) on age-corresponding autopsy tissue in different regions of the brain. In autopsy tissue, regional (frontal lobe, precentral area, basal ganglia, thalamus) and age-dependent differences of the concentration of creatine, NAA, and M-Ino were determined. In vivo measurement of NAA by proton magnetic resonance spectroscopy shows a significant increase of NAA by increasing postconceptional age. M-Ino shows a weak correlation and a nonsignificant decrease with increasing postconceptional age. Choline shows no age-dependent changes. Creatine concentrations measured by HPLC in different regions of the developing brain at autopsy showed an age-dependent increase that was identical for the left and right side and similar for the precentral area and frontal lobe and more pronounced for the basal ganglia and thalamus. Comparison of the results obtained by the two methods shows agreement for the age-dependent changes and the absolute concentration of M-Ino. NAA determined in autopsy tissue by HPLC is significantly lower than that measured in vivo by proton magnetic resonance spectroscopy. A comparison of the concentrations measured by HPLC in frontal lobe, basal ganglia, and thalamus with the results obtained from the precentral area showed significant regional differences in all measured metabolites. These results define important age-dependent changes detected with both methods and further indicate limitations of both methods that have to be considered when presenting absolute concentration values. More... »

PAGES

pr199526

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199502000-00003

DOI

http://dx.doi.org/10.1203/00006450-199502000-00003

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045664825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7731750


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aspartic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autopsy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choline", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, Gas", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatography, High Pressure Liquid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creatine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Premature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inositol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organ Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postmortem Changes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protons", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00fcppi", 
        "givenName": "Petra S", 
        "id": "sg:person.01347670513.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347670513.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fusch", 
        "givenName": "Christoph", 
        "id": "sg:person.01257656425.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257656425.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boesch", 
        "givenName": "Chris", 
        "id": "sg:person.012604610164.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012604610164.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burri", 
        "givenName": "Roland", 
        "id": "sg:person.01141630156.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141630156.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bossi", 
        "givenName": "Emilio", 
        "id": "sg:person.014671561205.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014671561205.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amato", 
        "givenName": "Maurizio", 
        "id": "sg:person.0657345466.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657345466.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bern", 
          "id": "https://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herschkowitz", 
        "givenName": "Norbert", 
        "id": "sg:person.0732503263.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732503263.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00004728-199011000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002884434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004728-199011000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002884434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199112000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014967845", 
          "https://doi.org/10.1203/00006450-199112000-00017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410220408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020041875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1988.tb04850.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00965747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030045162", 
          "https://doi.org/10.1007/bf00965747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910300405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032377665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1940020505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037260297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0720-048x(92)90226-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040394287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1940040203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048643842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.1987.tb05619.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052298103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a127068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083613477"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-02", 
    "datePublishedReg": "1995-02-01", 
    "description": "To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myoinositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and compared in vivo established spectroscopic data with classic chromatographic data (HPLC) on age-corresponding autopsy tissue in different regions of the brain. In autopsy tissue, regional (frontal lobe, precentral area, basal ganglia, thalamus) and age-dependent differences of the concentration of creatine, NAA, and M-Ino were determined. In vivo measurement of NAA by proton magnetic resonance spectroscopy shows a significant increase of NAA by increasing postconceptional age. M-Ino shows a weak correlation and a nonsignificant decrease with increasing postconceptional age. Choline shows no age-dependent changes. Creatine concentrations measured by HPLC in different regions of the developing brain at autopsy showed an age-dependent increase that was identical for the left and right side and similar for the precentral area and frontal lobe and more pronounced for the basal ganglia and thalamus. Comparison of the results obtained by the two methods shows agreement for the age-dependent changes and the absolute concentration of M-Ino. NAA determined in autopsy tissue by HPLC is significantly lower than that measured in vivo by proton magnetic resonance spectroscopy. A comparison of the concentrations measured by HPLC in frontal lobe, basal ganglia, and thalamus with the results obtained from the precentral area showed significant regional differences in all measured metabolites. These results define important age-dependent changes detected with both methods and further indicate limitations of both methods that have to be considered when presenting absolute concentration values.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1203/00006450-199502000-00003", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Regional Metabolic Assessment of Human Brain during Development by Proton Magnetic Resonance Spectroscopy In Vivo and by High-Performance Liquid Chromatography/Gas Chromatography in Autopsy Tissue", 
    "pagination": "pr199526", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d985cb42383795420e212d3d7b5c174536d0aa1ed7d1adc76929cf84c1720390"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7731750"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0100714"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-199502000-00003"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045664825"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-199502000-00003", 
      "https://app.dimensions.ai/details/publication/pub.1045664825"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/pr199526"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-199502000-00003'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-199502000-00003'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-199502000-00003'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-199502000-00003'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      59 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-199502000-00003 schema:about N0d2d96686108428ea5776a97d094555a
2 N1bce380dc6464da2ae911bcdf6493728
3 N1f6b974518b64dfea7d3f7c300051640
4 N26b4e26f987c43ce9c799a59c91e5882
5 N28aabec8c2044afcbcd9e0e926b57ce5
6 N35f27f340ccb4893b686761ca5a80aea
7 N432192a62e064c35aee570054d3d7678
8 N4779985f36f14868b12cbd19d7283d69
9 N499dc0b8bf2240beb1c866c92e96bba1
10 N4f3210c48c41470bbaa5a132b1516126
11 N51712df35fdb41b5b35dff28cfde07ec
12 N755e68d8d4fe49d2aa79e1f4a611449d
13 N7fb5a3c7badb4b7da171d4de1eca1a8a
14 N90b201c8ffc940f783e1b67ff9f12db4
15 Nbd828c0f83de4a75bf669cf747536188
16 Ne8d830a7e9d54ea7ad72591a3960bc7c
17 Nef433aea4f894362ab822f7af665a206
18 Nf203a3a17ef54c9286045acd8776af9d
19 Nfbb816bbfaf1443dab2f6fb8797e47d2
20 anzsrc-for:11
21 anzsrc-for:1109
22 schema:author N2b7c161454e44b568a86eeba9b912798
23 schema:citation sg:pub.10.1007/bf00965747
24 sg:pub.10.1203/00006450-199112000-00017
25 https://doi.org/10.1002/ana.410220408
26 https://doi.org/10.1002/mrm.1910300405
27 https://doi.org/10.1002/nbm.1940020505
28 https://doi.org/10.1002/nbm.1940040203
29 https://doi.org/10.1016/0720-048x(92)90226-y
30 https://doi.org/10.1093/oxfordjournals.jbchem.a127068
31 https://doi.org/10.1097/00004728-199011000-00003
32 https://doi.org/10.1111/j.1471-4159.1987.tb05619.x
33 https://doi.org/10.1111/j.1471-4159.1988.tb04850.x
34 schema:datePublished 1995-02
35 schema:datePublishedReg 1995-02-01
36 schema:description To study the course of regional metabolite concentrations during early brain development, we measured in vivo metabolites [N-acetyl-aspartate (NAA), choline-containing compounds, and myoinositol (M-Ino)] in the precentral area of the cerebrum by short echo-time single volume proton magnetic resonance spectroscopy and compared in vivo established spectroscopic data with classic chromatographic data (HPLC) on age-corresponding autopsy tissue in different regions of the brain. In autopsy tissue, regional (frontal lobe, precentral area, basal ganglia, thalamus) and age-dependent differences of the concentration of creatine, NAA, and M-Ino were determined. In vivo measurement of NAA by proton magnetic resonance spectroscopy shows a significant increase of NAA by increasing postconceptional age. M-Ino shows a weak correlation and a nonsignificant decrease with increasing postconceptional age. Choline shows no age-dependent changes. Creatine concentrations measured by HPLC in different regions of the developing brain at autopsy showed an age-dependent increase that was identical for the left and right side and similar for the precentral area and frontal lobe and more pronounced for the basal ganglia and thalamus. Comparison of the results obtained by the two methods shows agreement for the age-dependent changes and the absolute concentration of M-Ino. NAA determined in autopsy tissue by HPLC is significantly lower than that measured in vivo by proton magnetic resonance spectroscopy. A comparison of the concentrations measured by HPLC in frontal lobe, basal ganglia, and thalamus with the results obtained from the precentral area showed significant regional differences in all measured metabolites. These results define important age-dependent changes detected with both methods and further indicate limitations of both methods that have to be considered when presenting absolute concentration values.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N1bfe298efa214dbc93e9cdedf2527342
41 N61b9fd887bae49fa9d5f01a87cd5734e
42 sg:journal.1007352
43 schema:name Regional Metabolic Assessment of Human Brain during Development by Proton Magnetic Resonance Spectroscopy In Vivo and by High-Performance Liquid Chromatography/Gas Chromatography in Autopsy Tissue
44 schema:pagination pr199526
45 schema:productId N76833e8a12f04e129213335bdc7b5270
46 N7f85adbe459a4aa5a587ab4f5e9014c3
47 N926a6f69254549b891b177e6a942e114
48 Naa9a8855fad54c75923a6823fe852de1
49 Nbaef374e53704d13a084ac404f0789ff
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045664825
51 https://doi.org/10.1203/00006450-199502000-00003
52 schema:sdDatePublished 2019-04-10T12:59
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N8cf00e52088a4b72a6230af24d9ce5ab
55 schema:url http://www.nature.com/articles/pr199526
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N0d2d96686108428ea5776a97d094555a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Brain Chemistry
61 rdf:type schema:DefinedTerm
62 N1bce380dc6464da2ae911bcdf6493728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Inositol
64 rdf:type schema:DefinedTerm
65 N1bfe298efa214dbc93e9cdedf2527342 schema:issueNumber 2
66 rdf:type schema:PublicationIssue
67 N1f6b974518b64dfea7d3f7c300051640 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Postmortem Changes
69 rdf:type schema:DefinedTerm
70 N26b4e26f987c43ce9c799a59c91e5882 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Chromatography, Gas
72 rdf:type schema:DefinedTerm
73 N28aabec8c2044afcbcd9e0e926b57ce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Infant
75 rdf:type schema:DefinedTerm
76 N2b7c161454e44b568a86eeba9b912798 rdf:first sg:person.01347670513.55
77 rdf:rest Nb0c8081088604133aca845bf4a1c5c24
78 N35f27f340ccb4893b686761ca5a80aea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Organ Specificity
80 rdf:type schema:DefinedTerm
81 N36c33df3c3764347beace4e55a87f911 rdf:first sg:person.014671561205.50
82 rdf:rest N5e8123193aa34a5a8a9a50a1ae5f800d
83 N432192a62e064c35aee570054d3d7678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Autopsy
85 rdf:type schema:DefinedTerm
86 N4779985f36f14868b12cbd19d7283d69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Energy Metabolism
88 rdf:type schema:DefinedTerm
89 N499dc0b8bf2240beb1c866c92e96bba1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Brain
91 rdf:type schema:DefinedTerm
92 N4f3210c48c41470bbaa5a132b1516126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Magnetic Resonance Spectroscopy
94 rdf:type schema:DefinedTerm
95 N51712df35fdb41b5b35dff28cfde07ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Creatine
97 rdf:type schema:DefinedTerm
98 N5e8123193aa34a5a8a9a50a1ae5f800d rdf:first sg:person.0657345466.78
99 rdf:rest Nc9020ea95fcb4cacb8010050f1e06c21
100 N61b9fd887bae49fa9d5f01a87cd5734e schema:volumeNumber 37
101 rdf:type schema:PublicationVolume
102 N673ba2d524e941d0a572eb73bff2d7a0 rdf:first sg:person.012604610164.23
103 rdf:rest N8c0738159ace4268a8f301325807c559
104 N755e68d8d4fe49d2aa79e1f4a611449d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Age Factors
106 rdf:type schema:DefinedTerm
107 N76833e8a12f04e129213335bdc7b5270 schema:name nlm_unique_id
108 schema:value 0100714
109 rdf:type schema:PropertyValue
110 N7f85adbe459a4aa5a587ab4f5e9014c3 schema:name dimensions_id
111 schema:value pub.1045664825
112 rdf:type schema:PropertyValue
113 N7fb5a3c7badb4b7da171d4de1eca1a8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Chromatography, High Pressure Liquid
115 rdf:type schema:DefinedTerm
116 N8c0738159ace4268a8f301325807c559 rdf:first sg:person.01141630156.27
117 rdf:rest N36c33df3c3764347beace4e55a87f911
118 N8cf00e52088a4b72a6230af24d9ce5ab schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N90b201c8ffc940f783e1b67ff9f12db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Protons
122 rdf:type schema:DefinedTerm
123 N926a6f69254549b891b177e6a942e114 schema:name readcube_id
124 schema:value d985cb42383795420e212d3d7b5c174536d0aa1ed7d1adc76929cf84c1720390
125 rdf:type schema:PropertyValue
126 Naa9a8855fad54c75923a6823fe852de1 schema:name doi
127 schema:value 10.1203/00006450-199502000-00003
128 rdf:type schema:PropertyValue
129 Nb0c8081088604133aca845bf4a1c5c24 rdf:first sg:person.01257656425.44
130 rdf:rest N673ba2d524e941d0a572eb73bff2d7a0
131 Nbaef374e53704d13a084ac404f0789ff schema:name pubmed_id
132 schema:value 7731750
133 rdf:type schema:PropertyValue
134 Nbd828c0f83de4a75bf669cf747536188 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Choline
136 rdf:type schema:DefinedTerm
137 Nc9020ea95fcb4cacb8010050f1e06c21 rdf:first sg:person.0732503263.77
138 rdf:rest rdf:nil
139 Ne8d830a7e9d54ea7ad72591a3960bc7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Aspartic Acid
141 rdf:type schema:DefinedTerm
142 Nef433aea4f894362ab822f7af665a206 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Infant, Newborn
144 rdf:type schema:DefinedTerm
145 Nf203a3a17ef54c9286045acd8776af9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 Nfbb816bbfaf1443dab2f6fb8797e47d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Infant, Premature
150 rdf:type schema:DefinedTerm
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
155 schema:name Neurosciences
156 rdf:type schema:DefinedTerm
157 sg:journal.1007352 schema:issn 0031-3998
158 1530-0447
159 schema:name Pediatric Research
160 rdf:type schema:Periodical
161 sg:person.01141630156.27 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
162 schema:familyName Burri
163 schema:givenName Roland
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141630156.27
165 rdf:type schema:Person
166 sg:person.01257656425.44 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
167 schema:familyName Fusch
168 schema:givenName Christoph
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257656425.44
170 rdf:type schema:Person
171 sg:person.012604610164.23 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
172 schema:familyName Boesch
173 schema:givenName Chris
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012604610164.23
175 rdf:type schema:Person
176 sg:person.01347670513.55 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
177 schema:familyName Hüppi
178 schema:givenName Petra S
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347670513.55
180 rdf:type schema:Person
181 sg:person.014671561205.50 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
182 schema:familyName Bossi
183 schema:givenName Emilio
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014671561205.50
185 rdf:type schema:Person
186 sg:person.0657345466.78 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
187 schema:familyName Amato
188 schema:givenName Maurizio
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657345466.78
190 rdf:type schema:Person
191 sg:person.0732503263.77 schema:affiliation https://www.grid.ac/institutes/grid.5734.5
192 schema:familyName Herschkowitz
193 schema:givenName Norbert
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732503263.77
195 rdf:type schema:Person
196 sg:pub.10.1007/bf00965747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030045162
197 https://doi.org/10.1007/bf00965747
198 rdf:type schema:CreativeWork
199 sg:pub.10.1203/00006450-199112000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014967845
200 https://doi.org/10.1203/00006450-199112000-00017
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/ana.410220408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020041875
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1002/mrm.1910300405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032377665
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1002/nbm.1940020505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037260297
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/nbm.1940040203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048643842
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0720-048x(92)90226-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1040394287
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/oxfordjournals.jbchem.a127068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083613477
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1097/00004728-199011000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002884434
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1471-4159.1987.tb05619.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052298103
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1471-4159.1988.tb04850.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882432
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.5734.5 schema:alternateName University of Bern
221 schema:name Department of Pediatrics and Division of Magnetic Resonance Spectroscopy, University of Berne, Berne, Switzerland
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...