386 Psychiatric Disorders In Adult Patients With Phenylketonuria (Pku) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-07

AUTHORS

Joachim Pietz, Günther Esser, Meinrad Armbruster, Peter Burgard

ABSTRACT

Increased prevalence rates of psychopathology and manifest psychiatric disorders (i.e. agoraphobia) have been observed in patients with treated PKU. We investigated 24 adult patients with PKU type I (13 f, 11 m; age 20.8 years) with a highly structured 2-h psychiatric interview (MADELI, Esser 1989). Data were compared to a random sample of 181 18-year-old adults (CO). Overall we found a normal rate for psychiatric disturbances in PKU (PKU 21%, CO 16%). Though overall scale indexes were not significantly different, functional and emotional symptoms were slightly increased (scale index PKU 2.2, CO 1.45) and antisocial symptoms were reduced (PKU 0.38, CO 0.95)). Single symptoms were more frequent in PKU: Generalized anxiety (PKU 21%, CO 5%), phobia (PKU 38%, CO 16%), depressed mood (PKU 42%, CO 19%), problematic peer relations (PKU 71%, CO 42%) and siblings rivalry (PKU 29%; CO 7.5%) were significantly increased. 5 cases met the criteria of ICD-10 diagnoses. We found no correlation between psychiatric symptoms and phenylalanine levels as well as IQ (WAIS-R). Educational style of mothers was more frequently rated as ‘disturbed’ (‘overprotecting’ PKU 42%, CO 11%, ‘restrictive-controlling’ PKU 25%, CO 4%). Psychopathology in PKU has been attributed either to a disturbed regulation of neurotransmitters or psychological factors (related to the chronic disease and its dietary treatment). Our data favor a psychological explanation for abnormal behaviour in patients with PKU. (Grant DFG 196/3-1). More... »

PAGES

67a

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199407000-00386

DOI

http://dx.doi.org/10.1203/00006450-199407000-00386

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036866333


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