28 Effects Of Phenobarbital On Cerebral Hemodynamics In Preterm Neonates View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-12

AUTHORS

Elie Saliba, Elisabeth Autret, Louay Al Khadiry, Jean Laugier

ABSTRACT

We evaluated the effect of phenobarbital (pb) versus placebo (saline) on cerebral hemodynamics in eleven, clinically stable preterm neonates. The mean (+SD) post natal age at study entry was 12 (3) hours. The mean (+SD) birth weight and gestational age were 1286 (387 g) and 30.5 (3) weeks respectively. We measured cerebral blood flow velocity (CBFV), using a pulsed wave Doppler monitor. Every subject was his own control. Placebo was systematically injected prior to pb (20 mg.kg −1 over 20 min). Simultaneous recording of heart rate, arterial blood pressure, TcPCO2, TcPO2, SaO2 were made before, at the end of the injection, and a 15, 30, 60, 90, 120 min after the end of each administration of either placebo or pb. Results : pb was in anticonvulsant concentrations (16 to 24 μg/ml). No significant changes ocurred in systemic hemodynamics, or in blood gases. CBFV remains stable and no different during placebo or phenobarbital administration. We conclude that a pb loading dose of 20 mg −1, has no effect on systemic and cerebral hemodynamics during steady state. The cerebral protective action of phenobarbital may not result by decreasing baseline cerebral blood flow as previously suggested. More... »

PAGES

632-632

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-199112000-00058

DOI

http://dx.doi.org/10.1203/00006450-199112000-00058

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036734231


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