Utilization of D-β-Hydroxybutyrate and Oleate as Alternate Energy Fuels in Brain Cell Cultures of Newborn Mice after Hypoxia at Different ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1989-11

AUTHORS

E Bossi, E Kohler, N Herschkowitz

ABSTRACT

In dissociated whole brain cell cultures from newborn mice, we have previously shown that during glucose deprivation under normoxia, D-beta-hydroxybutyrate and oleic acid are increasingly used for energy production. We now asked whether this glucose dependency of the utilization of D-beta-hydroxybutyrate and oleic acid as alternate energy fuels is also present after a hypoxic phase. 3-Hydroxy[3-14C]butyrate or [U-14C]oleic acid were added to 7- and 14-d-old cultures and 14CO2-production compared after hypoxia in normal and glucose-deprived conditions. After hypoxia, the ability of the cells 7 d in culture to increase D-beta-hydroxybutyrate consumption in response to glucose deprivation is diminished, 14-d-old cells lose this ability. In contrast, after hypoxia, both 7- and 14-d-old cultures maintain or even improve the ability to increase oleate consumption, when glucose is lacking. More... »

PAGES

478

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198911000-00023

DOI

http://dx.doi.org/10.1203/00006450-198911000-00023

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009610465

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2510120


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