Protracted Diarrhoea And Autoimmune Enteropathy: A Generalised Autoimmune Gut Disorder With A Common Hla Haplotype View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1989-09

AUTHORS

S M Hill, R Mirakian, P J Milla

ABSTRACT

In children with protracted diarrhoea, circulating enterocyte auto-antibodies (Ec Ab's) and an enteropathy, diarrhoea may persist despite therapy. we have examined the colon endoscopically in 17 such patients. Multiple biopsies were studied histologically, and by immunocytochemistry for HLA class II expression and T cell populations, and compared with histologically normal colon from control subjects. In addition, in view of the probable autoimmune nature of the diarrhoea HLA typing was done. 14/17 patients had a colitis characterised endoscopically by oedema and patchy erythema throughout the colon, and histologically by an inflammatory infiltrate of lymphocytes and plasma cells without crypt dysplasia, goblet cell changes or epitheloid granulomas. Class II (DR complex) expression was absent in both surface and crypt colonocytes of histologically normal colon (controls and 3/17 patients), but aberrant expression of DR molecules was seen in the 14 patients with a colitis. DR + ve lamina propria lymphomononuclear cells were present in patients and controls. Intraepithelial T cells were increased in 1 of 2 patients examined, and were CD8 + ve. On peripheral blood HLA typing patients were predominantly HLA CW7 (67%), DR3 (58%) and commonly B8 (38%). Our data shows that the HLA type in children with autoiimune enteropathy is consistent with that seen in other auto-inmune diseases, and in over 80% intestinal inflammation extends to the colon where colonccytes may perpetuate the disease by acting as antigen presenting cells. More... »

PAGES

275

Journal

TITLE

Pediatric Research

ISSUE

3

VOLUME

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198909000-00068

DOI

http://dx.doi.org/10.1203/00006450-198909000-00068

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007380587


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Hill", 
        "givenName": "S M", 
        "id": "sg:person.01267201077.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267201077.32"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Mirakian", 
        "givenName": "R", 
        "id": "sg:person.01241577743.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241577743.18"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Milla", 
        "givenName": "P J", 
        "id": "sg:person.0662513433.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662513433.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1989-09", 
    "datePublishedReg": "1989-09-01", 
    "description": "In children with protracted diarrhoea, circulating enterocyte auto-antibodies (Ec Ab's) and an enteropathy, diarrhoea may persist despite therapy. we have examined the colon endoscopically in 17 such patients. Multiple biopsies were studied histologically, and by immunocytochemistry for HLA class II expression and T cell populations, and compared with histologically normal colon from control subjects. In addition, in view of the probable autoimmune nature of the diarrhoea HLA typing was done. 14/17 patients had a colitis characterised endoscopically by oedema and patchy erythema throughout the colon, and histologically by an inflammatory infiltrate of lymphocytes and plasma cells without crypt dysplasia, goblet cell changes or epitheloid granulomas. Class II (DR complex) expression was absent in both surface and crypt colonocytes of histologically normal colon (controls and 3/17 patients), but aberrant expression of DR molecules was seen in the 14 patients with a colitis. DR + ve lamina propria lymphomononuclear cells were present in patients and controls. Intraepithelial T cells were increased in 1 of 2 patients examined, and were CD8 + ve. On peripheral blood HLA typing patients were predominantly HLA CW7 (67%), DR3 (58%) and commonly B8 (38%). Our data shows that the HLA type in children with autoiimune enteropathy is consistent with that seen in other auto-inmune diseases, and in over 80% intestinal inflammation extends to the colon where colonccytes may perpetuate the disease by acting as antigen presenting cells.", 
    "genre": "non_research_article", 
    "id": "sg:pub.10.1203/00006450-198909000-00068", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "26"
      }
    ], 
    "name": "PROTRACTED DIARRHOEA AND AUTOIMMUNE ENTEROPATHY: A GENERALISED AUTOIMMUNE GUT DISORDER WITH A COMMON HLA HAPLOTYPE", 
    "pagination": "275", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2327fdeabdc1140fef1cb61fab0ed37df90890cafb904ac090eb0c0c83002c62"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-198909000-00068"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007380587"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-198909000-00068", 
      "https://app.dimensions.ai/details/publication/pub.1007380587"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/pr1989277"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-198909000-00068'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-198909000-00068'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-198909000-00068'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-198909000-00068'


 

This table displays all metadata directly associated to this object as RDF triples.

69 TRIPLES      20 PREDICATES      27 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-198909000-00068 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N695ad496fed14bc4aa1c5daa18f849d8
4 schema:datePublished 1989-09
5 schema:datePublishedReg 1989-09-01
6 schema:description In children with protracted diarrhoea, circulating enterocyte auto-antibodies (Ec Ab's) and an enteropathy, diarrhoea may persist despite therapy. we have examined the colon endoscopically in 17 such patients. Multiple biopsies were studied histologically, and by immunocytochemistry for HLA class II expression and T cell populations, and compared with histologically normal colon from control subjects. In addition, in view of the probable autoimmune nature of the diarrhoea HLA typing was done. 14/17 patients had a colitis characterised endoscopically by oedema and patchy erythema throughout the colon, and histologically by an inflammatory infiltrate of lymphocytes and plasma cells without crypt dysplasia, goblet cell changes or epitheloid granulomas. Class II (DR complex) expression was absent in both surface and crypt colonocytes of histologically normal colon (controls and 3/17 patients), but aberrant expression of DR molecules was seen in the 14 patients with a colitis. DR + ve lamina propria lymphomononuclear cells were present in patients and controls. Intraepithelial T cells were increased in 1 of 2 patients examined, and were CD8 + ve. On peripheral blood HLA typing patients were predominantly HLA CW7 (67%), DR3 (58%) and commonly B8 (38%). Our data shows that the HLA type in children with autoiimune enteropathy is consistent with that seen in other auto-inmune diseases, and in over 80% intestinal inflammation extends to the colon where colonccytes may perpetuate the disease by acting as antigen presenting cells.
7 schema:genre non_research_article
8 schema:inLanguage en
9 schema:isAccessibleForFree true
10 schema:isPartOf N2bdd7ec0f860454d8626201757ea620b
11 N444c71b9a2224e848c9de061fecd199a
12 sg:journal.1007352
13 schema:name PROTRACTED DIARRHOEA AND AUTOIMMUNE ENTEROPATHY: A GENERALISED AUTOIMMUNE GUT DISORDER WITH A COMMON HLA HAPLOTYPE
14 schema:pagination 275
15 schema:productId N58a02ff5cdf54c17af20c61aff97fea7
16 N58b750d682834ba49379c56d68bb75ed
17 Nc61756dccc204176bf36f2e6c7198582
18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007380587
19 https://doi.org/10.1203/00006450-198909000-00068
20 schema:sdDatePublished 2019-04-11T00:54
21 schema:sdLicense https://scigraph.springernature.com/explorer/license/
22 schema:sdPublisher Ne6b7ddf550c641d2a18378904f4822c7
23 schema:url https://www.nature.com/articles/pr1989277
24 sgo:license sg:explorer/license/
25 sgo:sdDataset articles
26 rdf:type schema:ScholarlyArticle
27 N19ab24305037476eba31617ea1b674fc rdf:first sg:person.01241577743.18
28 rdf:rest Nc684ed6a564549c585255c7419d318cf
29 N2bdd7ec0f860454d8626201757ea620b schema:issueNumber 3
30 rdf:type schema:PublicationIssue
31 N444c71b9a2224e848c9de061fecd199a schema:volumeNumber 26
32 rdf:type schema:PublicationVolume
33 N58a02ff5cdf54c17af20c61aff97fea7 schema:name readcube_id
34 schema:value 2327fdeabdc1140fef1cb61fab0ed37df90890cafb904ac090eb0c0c83002c62
35 rdf:type schema:PropertyValue
36 N58b750d682834ba49379c56d68bb75ed schema:name dimensions_id
37 schema:value pub.1007380587
38 rdf:type schema:PropertyValue
39 N695ad496fed14bc4aa1c5daa18f849d8 rdf:first sg:person.01267201077.32
40 rdf:rest N19ab24305037476eba31617ea1b674fc
41 Nc61756dccc204176bf36f2e6c7198582 schema:name doi
42 schema:value 10.1203/00006450-198909000-00068
43 rdf:type schema:PropertyValue
44 Nc684ed6a564549c585255c7419d318cf rdf:first sg:person.0662513433.51
45 rdf:rest rdf:nil
46 Ne6b7ddf550c641d2a18378904f4822c7 schema:name Springer Nature - SN SciGraph project
47 rdf:type schema:Organization
48 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
49 schema:name Medical and Health Sciences
50 rdf:type schema:DefinedTerm
51 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
52 schema:name Immunology
53 rdf:type schema:DefinedTerm
54 sg:journal.1007352 schema:issn 0031-3998
55 1530-0447
56 schema:name Pediatric Research
57 rdf:type schema:Periodical
58 sg:person.01241577743.18 schema:familyName Mirakian
59 schema:givenName R
60 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241577743.18
61 rdf:type schema:Person
62 sg:person.01267201077.32 schema:familyName Hill
63 schema:givenName S M
64 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267201077.32
65 rdf:type schema:Person
66 sg:person.0662513433.51 schema:familyName Milla
67 schema:givenName P J
68 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662513433.51
69 rdf:type schema:Person
 




Preview window. Press ESC to close (or click here)


...