Sexual Differentiation of Rat Hepatic Bile Salt Sulfotransferase Isoenzymes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1988-08

AUTHORS

Robert E Kane, Lee J Chen, John J Herbst, M Michael Thaler

ABSTRACT

ABSTRACT: The mature female rat has three times the hepatic bile salt sulfotransferase (BSS) activity compared with male rats. This study examined the changes in two hepatic BSS isoenzyme activities during sexual maturation, and the role of estrogen in development of sex differences in BSS activities in mature rats. DEAE-Sephadex A-50 chromatography of hepatic cytosol from prepubescent pups revealed that more than 90% of total BSS activity was due to BSS I activity relative to BSS II, similar to postpubertal females. Sex differences in total BSS activities and the isoenzyme patterns developed after the onset of puberty at 30–35 days of age. BSS I was still the predominant isoenzyme in the adolescent female, similar to the prepubescent pup and mature female. In contrast, BSS I activity declined in adolescent males, which appeared to explain the fall in total BSS activity to only one-third of that of the female by maturity. BSS II activity was similar in both sexes at any age. Estrogen treatment of postpubertal male rats rapidly increased hepatic BSS capacity by enhancing BSS I activity producing an isoenzyme pattern similar to the mature female. This rapid enhancement of BSS I by estrogen was blocked by actinomycin D and puromycin. We concluded that 1) sex differences in BSS activities that develop during adolescence were in part due estrogen-maintaining BSS I activity in females and 2) estrogen regulates the synthesis of BSS I at a translational (or pretranslational) level. More... »

PAGES

247-253

References to SciGraph publications

  • 1969. Cholestasis of Pregnancy and during Ethinyl Estradiol Administration in the Human and Rat in METABOLIC EFFECTS OF GONADAL HORMONES AND CONTRACEPTIVE STEROIDS
  • 1976. Toxic Effects of Lithocholate on the Liver and Biliary Tree in THE HEPATOBILIARY SYSTEM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1203/00006450-198808000-00022

    DOI

    http://dx.doi.org/10.1203/00006450-198808000-00022

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018428335

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/3186336


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