Bromocriptine (Brc) Treatment In Excessively Tall Boys. A Pair-Matched Controlled Study View Full Text


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Article Info

DATE

1986-11

AUTHORS

H P Schwarz, E Joss, K Zuppinger

ABSTRACT

Recently, BRC has been proposed as a novel agent for the treatment of tall stature in adolescents based on its ability to reduce adult height prediction (HP). Eight boys with a chronological age of 10.3-15.4 yrs (mean 13.3 yrs) were treated for 1 yr with BRC 7.5 mg daily. At the onset of therapy, adult height prediction according to Bayley-Pinneau (HP-BP) was 200.7 to 209.7 cm and according to Tanner Mark II (HP-TWII) 199.0-211.5 cm. After 1 yr of therapy, HP with both methods had decreased in every boy, changing by -4.13±1.86(SD) cm (HP-BP) or -3.35±2.39(SD) cm (HP-TWII), respectively. To substantiate these findings, each patient was pair-matched with a control, an untreated boy with a height above +2SDS and a bone age differing less than 0.5 yr. HP-BP was significantly reduced in patients after 1 yr of BRC compared with their matched controls after 1 yr of follow-up (p less than 0.02). By contrast, differences in HP-TWII were not significant. Because of this discrepancy it is uncertain whether final height in tall boys will really be reduced by treatment with BRC. More... »

PAGES

1196

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198611000-00138

DOI

http://dx.doi.org/10.1203/00006450-198611000-00138

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009935922


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