82 Pharmacokinetics Of Netilmicin In Neonates View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1986-10

AUTHORS

E Autret, C Lionnet, J Laugier, M Breteau

ABSTRACT

Studies in animals and in adults have shown that netilmicin (NM) is as effective but less nephrotoxic or oxotoxic than other aminoglucosides. There are few data on the use of NM in neonates, which can help the neonatologist to predict situations during which NM monitoring will be necessary.54 pharmacokinetic (PK) NM studies were performed: in 31 fullterm and 14 preterm babies. 3 mg/kg/12 h of NM was administered by 30 mn infusion in 40 cases and by IM route in 14 cases. Serum concentrations were analyzed by fluorescence polarization. For IV and IM route the mean peak serum level was 5.57 mg/l and 6.34 mg/l, recpectively, the mean through level was 1.66 mg/l and 2.36 mg/l. Mean concentrations were significantly higher with the IM than with the IV route because of the slow IV administration. In the 9 children with two successive pharmacokinetic studies the mean plasma levels were significantly higher during the second study, suggesting an accumulation of NM. The serum half life was higher:1) in preterms (7.19 h) than in fullterms (5.84 h).2) in neonates with proven infections (8.5 h) than in those with suspected infections (5.4 h) suggesting poor hemodynaraic conditions in those babies with diminution of clearance of NM.Our study shows that 3 mg/kg by 30 mn IV infusion of NM is safe in neonates without dangerous peak levels: it will be useful to monitor NM levels in preterm babies, neonates with proven infections and during treatment longer than 7 days. More... »

PAGES

1047-1047

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198610000-00136

DOI

http://dx.doi.org/10.1203/00006450-198610000-00136

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023332147


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Gatien de Clocheville, 37000, Tours, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "H\u00f4pital Gatien de Clocheville, 37000, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Autret", 
        "givenName": "E", 
        "id": "sg:person.01233433262.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233433262.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Gatien de Clocheville, 37000, Tours, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "H\u00f4pital Gatien de Clocheville, 37000, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lionnet", 
        "givenName": "C", 
        "id": "sg:person.01246247176.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246247176.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Gatien de Clocheville, 37000, Tours, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "H\u00f4pital Gatien de Clocheville, 37000, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laugier", 
        "givenName": "J", 
        "id": "sg:person.01227406233.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227406233.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Gatien de Clocheville, 37000, Tours, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "H\u00f4pital Gatien de Clocheville, 37000, Tours, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Breteau", 
        "givenName": "M", 
        "id": "sg:person.01265345432.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265345432.75"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1986-10", 
    "datePublishedReg": "1986-10-01", 
    "description": "Studies in animals and in adults have shown that netilmicin (NM) is as effective but less nephrotoxic or oxotoxic than other aminoglucosides. There are few data on the use of NM in neonates, which can help the neonatologist to predict situations during which NM monitoring will be necessary.54 pharmacokinetic (PK) NM studies were performed: in 31 fullterm and 14 preterm babies. 3 mg/kg/12 h of NM was administered by 30 mn infusion in 40 cases and by IM route in 14 cases. Serum concentrations were analyzed by fluorescence polarization. For IV and IM route the mean peak serum level was 5.57 mg/l and 6.34 mg/l, recpectively, the mean through level was 1.66 mg/l and 2.36 mg/l. Mean concentrations were significantly higher with the IM than with the IV route because of the slow IV administration. In the 9 children with two successive pharmacokinetic studies the mean plasma levels were significantly higher during the second study, suggesting an accumulation of NM. The serum half life was higher:1) in preterms (7.19 h) than in fullterms (5.84 h).2) in neonates with proven infections (8.5 h) than in those with suspected infections (5.4 h) suggesting poor hemodynaraic conditions in those babies with diminution of clearance of NM.Our study shows that 3 mg/kg by 30 mn IV infusion of NM is safe in neonates without dangerous peak levels: it will be useful to monitor NM levels in preterm babies, neonates with proven infections and during treatment longer than 7 days.", 
    "genre": "article", 
    "id": "sg:pub.10.1203/00006450-198610000-00136", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1007352", 
        "issn": [
          "0031-3998", 
          "1530-0447"
        ], 
        "name": "Pediatric Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "keywords": [
      "preterm babies", 
      "IM route", 
      "mean peak serum level", 
      "use of netilmicin", 
      "accumulation of Netilmicin", 
      "peak serum levels", 
      "mean plasma levels", 
      "serum half life", 
      "serum levels", 
      "kg/12 h", 
      "serum concentrations", 
      "plasma levels", 
      "neonates", 
      "netilmicin", 
      "peak levels", 
      "babies", 
      "infection", 
      "fullterm", 
      "pharmacokinetic study", 
      "NM studies", 
      "infusion", 
      "half life", 
      "second study", 
      "mean concentration", 
      "preterm", 
      "levels", 
      "neonatologists", 
      "PHARMACOKINETICS", 
      "study", 
      "aminoglucosides", 
      "administration", 
      "nephrotoxic", 
      "clearance", 
      "adults", 
      "treatment", 
      "children", 
      "cases", 
      "animals", 
      "days", 
      "diminution", 
      "concentration", 
      "IM", 
      "life", 
      "nM level", 
      "route", 
      "accumulation", 
      "fluorescence polarization", 
      "monitoring", 
      "use", 
      "data", 
      "means", 
      "conditions", 
      "situation", 
      "polarization", 
      "NM monitoring", 
      "pharmacokinetic (PK) NM studies", 
      "successive pharmacokinetic studies", 
      "poor hemodynaraic conditions", 
      "hemodynaraic conditions", 
      "diminution of clearance", 
      "infusion of NM", 
      "dangerous peak levels", 
      "PHARMACOKINETICS OF NETILMICIN"
    ], 
    "name": "82 PHARMACOKINETICS OF NETILMICIN IN NEONATES", 
    "pagination": "1047-1047", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023332147"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1203/00006450-198610000-00136"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1203/00006450-198610000-00136", 
      "https://app.dimensions.ai/details/publication/pub.1023332147"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T17:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_200.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1203/00006450-198610000-00136"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1203/00006450-198610000-00136'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1203/00006450-198610000-00136'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1203/00006450-198610000-00136'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1203/00006450-198610000-00136'


 

This table displays all metadata directly associated to this object as RDF triples.

142 TRIPLES      21 PREDICATES      89 URIs      81 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1203/00006450-198610000-00136 schema:about anzsrc-for:11
2 anzsrc-for:1114
3 schema:author N46cf95e428ec4f6b849d8a8c07954d29
4 schema:datePublished 1986-10
5 schema:datePublishedReg 1986-10-01
6 schema:description Studies in animals and in adults have shown that netilmicin (NM) is as effective but less nephrotoxic or oxotoxic than other aminoglucosides. There are few data on the use of NM in neonates, which can help the neonatologist to predict situations during which NM monitoring will be necessary.54 pharmacokinetic (PK) NM studies were performed: in 31 fullterm and 14 preterm babies. 3 mg/kg/12 h of NM was administered by 30 mn infusion in 40 cases and by IM route in 14 cases. Serum concentrations were analyzed by fluorescence polarization. For IV and IM route the mean peak serum level was 5.57 mg/l and 6.34 mg/l, recpectively, the mean through level was 1.66 mg/l and 2.36 mg/l. Mean concentrations were significantly higher with the IM than with the IV route because of the slow IV administration. In the 9 children with two successive pharmacokinetic studies the mean plasma levels were significantly higher during the second study, suggesting an accumulation of NM. The serum half life was higher:1) in preterms (7.19 h) than in fullterms (5.84 h).2) in neonates with proven infections (8.5 h) than in those with suspected infections (5.4 h) suggesting poor hemodynaraic conditions in those babies with diminution of clearance of NM.Our study shows that 3 mg/kg by 30 mn IV infusion of NM is safe in neonates without dangerous peak levels: it will be useful to monitor NM levels in preterm babies, neonates with proven infections and during treatment longer than 7 days.
7 schema:genre article
8 schema:inLanguage en
9 schema:isAccessibleForFree true
10 schema:isPartOf N02677af1a4214f7fb2e67471ad3b2458
11 Ne081c62cb7c1497496a36bb5fbab9158
12 sg:journal.1007352
13 schema:keywords IM
14 IM route
15 NM monitoring
16 NM studies
17 PHARMACOKINETICS
18 PHARMACOKINETICS OF NETILMICIN
19 accumulation
20 accumulation of Netilmicin
21 administration
22 adults
23 aminoglucosides
24 animals
25 babies
26 cases
27 children
28 clearance
29 concentration
30 conditions
31 dangerous peak levels
32 data
33 days
34 diminution
35 diminution of clearance
36 fluorescence polarization
37 fullterm
38 half life
39 hemodynaraic conditions
40 infection
41 infusion
42 infusion of NM
43 kg/12 h
44 levels
45 life
46 mean concentration
47 mean peak serum level
48 mean plasma levels
49 means
50 monitoring
51 nM level
52 neonates
53 neonatologists
54 nephrotoxic
55 netilmicin
56 peak levels
57 peak serum levels
58 pharmacokinetic (PK) NM studies
59 pharmacokinetic study
60 plasma levels
61 polarization
62 poor hemodynaraic conditions
63 preterm
64 preterm babies
65 route
66 second study
67 serum concentrations
68 serum half life
69 serum levels
70 situation
71 study
72 successive pharmacokinetic studies
73 treatment
74 use
75 use of netilmicin
76 schema:name 82 PHARMACOKINETICS OF NETILMICIN IN NEONATES
77 schema:pagination 1047-1047
78 schema:productId N25141eeb7ab446e58153d788128d0811
79 N69b2b5ba515d49b397d4462666f3ed3d
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023332147
81 https://doi.org/10.1203/00006450-198610000-00136
82 schema:sdDatePublished 2021-11-01T17:57
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N7bda6c337bde471dac88b5c663c6776d
85 schema:url https://doi.org/10.1203/00006450-198610000-00136
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N02677af1a4214f7fb2e67471ad3b2458 schema:issueNumber 10
90 rdf:type schema:PublicationIssue
91 N25141eeb7ab446e58153d788128d0811 schema:name dimensions_id
92 schema:value pub.1023332147
93 rdf:type schema:PropertyValue
94 N46cf95e428ec4f6b849d8a8c07954d29 rdf:first sg:person.01233433262.98
95 rdf:rest Nffd8020fe6254dfa829c0685d70036d1
96 N69b2b5ba515d49b397d4462666f3ed3d schema:name doi
97 schema:value 10.1203/00006450-198610000-00136
98 rdf:type schema:PropertyValue
99 N7bda6c337bde471dac88b5c663c6776d schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N97d06957c2e748e48dab2551c05adfc6 rdf:first sg:person.01227406233.35
102 rdf:rest Nebe72e108af34228a013c6c385d98686
103 Ne081c62cb7c1497496a36bb5fbab9158 schema:volumeNumber 20
104 rdf:type schema:PublicationVolume
105 Nebe72e108af34228a013c6c385d98686 rdf:first sg:person.01265345432.75
106 rdf:rest rdf:nil
107 Nffd8020fe6254dfa829c0685d70036d1 rdf:first sg:person.01246247176.39
108 rdf:rest N97d06957c2e748e48dab2551c05adfc6
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
113 schema:name Paediatrics and Reproductive Medicine
114 rdf:type schema:DefinedTerm
115 sg:journal.1007352 schema:issn 0031-3998
116 1530-0447
117 schema:name Pediatric Research
118 schema:publisher Springer Nature
119 rdf:type schema:Periodical
120 sg:person.01227406233.35 schema:affiliation grid-institutes:None
121 schema:familyName Laugier
122 schema:givenName J
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227406233.35
124 rdf:type schema:Person
125 sg:person.01233433262.98 schema:affiliation grid-institutes:None
126 schema:familyName Autret
127 schema:givenName E
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233433262.98
129 rdf:type schema:Person
130 sg:person.01246247176.39 schema:affiliation grid-institutes:None
131 schema:familyName Lionnet
132 schema:givenName C
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246247176.39
134 rdf:type schema:Person
135 sg:person.01265345432.75 schema:affiliation grid-institutes:None
136 schema:familyName Breteau
137 schema:givenName M
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265345432.75
139 rdf:type schema:Person
140 grid-institutes:None schema:alternateName Hôpital Gatien de Clocheville, 37000, Tours, France
141 schema:name Hôpital Gatien de Clocheville, 37000, Tours, France
142 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...