1639 Effect Of The Nephrotic Syndrome On The Concentration Of Serum Complement Components View Full Text


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Article Info

DATE

1985-04

AUTHORS

C Frederic Strife, Elizabeth C Jackson, Judith Forristal, Clark D West

ABSTRACT

The concentration of twelve component and four control proteins of the complement system were measured in serum from 43 children with a nephrotic syndrome which subsequently proved to be steroid responsive and from 13 children with focal glomerulosclerosis (FGS) and compared to values from 197 normal subjects. Of classical pathway complement components, 40% of patients had low Clq and 20%, low C2 levels. Mean serum levels of Cls, C4, C1INH and C4bp were elev,ated. Of alternative pathway components, factors B and I were low in one-third while levels of C3 and H were commonly elevated. Of the terminal components, only C8 and C9 were low. In five FGS patients with hypoalbuminemia without edema, all component levels were normal. With the exception of C1q, C1s and C8, high molecular weight components were in high concentration and low molecular weight components in low concentration. The three exceptions may be explained by the sub-unit structure of C1 and C8. From a practical standpoint, the study indicates that edematous patients with a nephrotic syndrome may have low serum levels of C1q and C2, simulating classical pathway complement activation such as commonly occurs in glomerulonephritis. However, low levels of C4 and possibly C1s can be used as indicators of classical pathway activation since their levels are not reduced by a nephrotic syndrome. More... »

PAGES

384a

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198504000-01663

DOI

http://dx.doi.org/10.1203/00006450-198504000-01663

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000081414


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