1170 Prolonged Oropharyngeal Excretion Of Epstein-Barr Virus From Children After Infectious Mononucleosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1985-04

AUTHORS

Ciro V Sumaya, Yasmin Ench

ABSTRACT

The duration of oropharyngeal excretion of Epstein-Barr virus (EBV) in children following an episode of EBV-induced infectious mononucleosis (IM) has not been reported. In the present study children with clinical, hematologic, and viral-specific serologic findings of EBV-IM were evaluated prospectively for oropharyngeal excretion of EBV. Viral isolation was determined by transformation and induction of EBV-nuclear antigen in umbilical cord lymphocyte cultures inoculated with oropharyngeal secretions. Seventy-five (74.3%) of 101 study children examined during the initial 3 weeks after clinical onset were positive for oropharyngeal EBV. Followup examinations at 4-8 week, 9-28 week, and 29-34 weeks revealed the presence of oropharyngeal EBV in 21 (55.3%) of 38, 19 (50.0%) of 38, and 13 (61.9%) of 21 children tested, respectively. The only significant difference in excretion rates with time was between the intervals 0-3 weeks and 9-28 weeks (p <.01). There was no difference in prevalence of EBV excretion related to age or serologic findings. The role that this long-term viral excretion has in the transmission of EBV remains to be elucidated. More... »

PAGES

305a

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198504000-01200

DOI

http://dx.doi.org/10.1203/00006450-198504000-01200

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049524277


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