The Proportion of Mitochondrial Isoenzyme of Aspartate Aminotransferase Is Not Elevated in Reye's Syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1983-11

AUTHORS

Donald M Mock, Marion Scott, Nell I Mock, M Michael Thaler

ABSTRACT

Summary: We reexamined a previously reported, highly specific increase in the relative proportion of the mitochondrial isoenzyme of asparate aminotransferase (AST) in the serum of patients with Reye's Syndrome. Using ion exchange chromatography, we measured mitochondrial, cytosolic, and total AST in serum samples from (1) 10 patients early in the course of Reye's Syndrome; (2) nine controls with normal serum AST; and (3) seven controls with other diseases causing an increase in serum AST. The mitochondrial percentage (2.8 ± 2.0%) in Reye's Syndrome was significantly lower (P < 0.05) than that of both the normal control group (6.1 ± 7.1%) and the group with increased AST (5.6 ± 4.0%). We thus failed to confirm the previous report of a specific increase in the % of mitochondrial isoenzyme in Reye's Syndrome, and conclude that the % of mitochondrial isoenzyme is not likely to be a useful marker of (or predictor for progression to) Reye's Syndrome. More... »

PAGES

884-888

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198311000-00009

DOI

http://dx.doi.org/10.1203/00006450-198311000-00009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023005227

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6646898


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