HLA-antigens in Familial Insulin Dependent Diabetes of childhood (IDD) in The Netherlands View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-12

AUTHORS

G J Bruining, B M de Jongh, R K B Schuurman, J Molenaar, S L S Drop, H K A Visser, J J van Rood

ABSTRACT

Twenty-two Dutch Caucasoid families were ascertained for two or more children with IDM. The HLA-A, B, C and DR antigens and C4, BF, C2 and GLO polymorphisms were determined and the sera were screened for various autoimmune antibodies. We also determined a locally defined split of DR4 (LB4 and LB10). Fourteen families had two children affected, one three and one four (Group A). Six families had two children and one parent affected (Group B). The probands (first affected child per family) showed, after correction for the number of antigens tested, a significant increase in DR3 and DR4. However the increase in DR4 was due to an increase in LB4 alone and not to LB10. The decrease in DR2 was not significant. More... »

PAGES

1566

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198112000-00187

DOI

http://dx.doi.org/10.1203/00006450-198112000-00187

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020242609


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