1421 Corticosteroid Responsiveness In Chronic Lung Disease Of Prematurity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-04

AUTHORS

J B Schick, B W Goetzman, L E Smith, R P Wennberg

ABSTRACT

Corticosteroids (CS) have been anecdotally reported to improve chronic lung disease (CLD) in premature infants. Concern over equivocal results and long-term CNS effects prompted us to review our clinical experience. Between 01/78 and 11/80 we cared for 16 premature infants with clinical and X-ray diagnosis of CLD, O2 requirement >30 days and AaDO2 >100 who received CS for >48 hrs (mean dose 4.04 ± 1.66 mg/kg/day prednisone equivalent). A positive response to CS was defined as a >30% drop in AaDO2 by days 4-6 post introduction of CS which was sustained for >7 days. Eight positive responses in 8 infants and 10 failures to respond in another 8 infants were found. Responders had lower birth-weights (p <0.01), gestational ages (p <0.05) and gained more weight/day prior to CS (p <0.01) as compared to nonresponders and decreased PCO2 (p <0.05) pre- and post CS. There was no difference between the two groups in mean AaDO2, weight at time of treatment, or the dose given, X-ray appearance, postnatal age, mortality and duration of O2 therapy. Nine infants with CLD who did not receive CS were selected as a control group. Only one had a dramatic but transient decrease in O2 requirement similar to the defined positive response. In conclusion, 50% of infants receiving CS had a dramatic improvement in their lung function. However, it is unclear whether this treatment altered their long-term outcome. CS responsiveness may be a function of some unrecognized etiologic difference or complication of CLD. More... »

PAGES

680-680

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198104001-01450

DOI

http://dx.doi.org/10.1203/00006450-198104001-01450

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010179348


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