832 Abnormal Ct Brain Scans In Children With Acute Lymphoblastic Leukemia (All) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-04

AUTHORS

Donald H Mahoney, Daniel G Glaze, L Paul Gerson, Kenneth A Starling, James D Easley

ABSTRACT

The results of CT brain scans in 2 groups of children with ALL are reviewed. In Group I, 25 asymptomatic children 3-5 yrs from initial diagnosis were studied upon discontinuation of therapy. Mild ventricular dilation (5/25) and cerebral calcifications (1/25) were noted. Of the 6 patients with abnormal CT scans, radiotherapy + intrathecal methotrexate were used in 4/6 patients and intrathecal therapy alone in 2/6 patients. Subsequent neurological complications were uncommon (1/25). In Group II, 14 children who developed neurologic syndromes were studied while still receiving therapy. Leukoencephalopathic syndromes were diagnosed in 10/14 children; central nervous system (CNS) leukemia occurred in 6/10 children. CT scan abnormalities occurred in 9/10 patients. CT scans indicated ventricular dilation alone in 1 patient, and both ventricular and subarachnoid space dilation in 8 patients; in addition, 2 patients had areas of intracerebral calcification in areas of decreased attenuation coefficient. CNS infections were subsequently identified in 2/10 patients (toxoplasmosis and St. Louis encephalitis). Significant CT scan abnormalities are more likely to be seen in patients with antecedent clinical problems or in patients receiving more intensive CNS therapy. More... »

PAGES

581

Journal

TITLE

Pediatric Research

ISSUE

S4

VOLUME

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198104001-00857

DOI

http://dx.doi.org/10.1203/00006450-198104001-00857

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020935656


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