Ontology type: schema:ScholarlyArticle Open Access: True
1981-04
AUTHORSDonald H Mahoney, Daniel G Glaze, L Paul Gerson, Kenneth A Starling, James D Easley
ABSTRACTThe results of CT brain scans in 2 groups of children with ALL are reviewed. In Group I, 25 asymptomatic children 3-5 yrs from initial diagnosis were studied upon discontinuation of therapy. Mild ventricular dilation (5/25) and cerebral calcifications (1/25) were noted. Of the 6 patients with abnormal CT scans, radiotherapy + intrathecal methotrexate were used in 4/6 patients and intrathecal therapy alone in 2/6 patients. Subsequent neurological complications were uncommon (1/25). In Group II, 14 children who developed neurologic syndromes were studied while still receiving therapy. Leukoencephalopathic syndromes were diagnosed in 10/14 children; central nervous system (CNS) leukemia occurred in 6/10 children. CT scan abnormalities occurred in 9/10 patients. CT scans indicated ventricular dilation alone in 1 patient, and both ventricular and subarachnoid space dilation in 8 patients; in addition, 2 patients had areas of intracerebral calcification in areas of decreased attenuation coefficient. CNS infections were subsequently identified in 2/10 patients (toxoplasmosis and St. Louis encephalitis). Significant CT scan abnormalities are more likely to be seen in patients with antecedent clinical problems or in patients receiving more intensive CNS therapy. More... »
PAGES581
http://scigraph.springernature.com/pub.10.1203/00006450-198104001-00857
DOIhttp://dx.doi.org/10.1203/00006450-198104001-00857
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