Effect of Glucose Deprivation on Sulfatide Synthesis and Oligodendrocytes in Cultured Brain Cells of Newborn Mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1981-04

AUTHORS

K Zuppinger, U Wiesmann, H P Siegrist, T Schäfer, L Sandru, H P Schwarz, N Herschkowitz

ABSTRACT

Summary: The present work was designed to develop a model for studying the effect of substrates on brain cell metabolism. The synthesis of sulfatide, a myelin lipid, which takes place predominantly in oligodendrocytes was measured in vitro in dissociated cell cultures of newborn mouse brains at 13 days in culture. This corresponds to an active stage of in vivo myelination. The effect of increasing durations of severe glucose deprivation (below 1 mM in the medium) was assessed on morphology, cellular protein, DNA, sulfatide synthesis, cerebroside sulfotransferase activity, and mucopolysaccharide synthesis. More... »

PAGES

319

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-198104000-00006

DOI

http://dx.doi.org/10.1203/00006450-198104000-00006

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031494367

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6111779


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