819 Serologic And Virologic Studies Of Epstein-Barr Virus Infections In Children With An Infectious Mononucleosis (Im) -Like Disease View Full Text


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Article Info

DATE

1978-04

AUTHORS

Ciro V Sumaya, Yasmin Ench

ABSTRACT

Few data are available about the antibody response to Epstein-Barr virus(EBV) and the rate of isolation of this virus in children with an IM-like disease. Twenty-five children presenting with a clinical picture suggesting this diagnosis are the subject of this report. Fourteen children were 4 mo to 5 yrs of age, eleven were 6 to 16 yrs. High antibody(IgG) titers(>160) to viral capsid antigen of EBV were detected in the sera of 15(60%.) of the children. Antibodies to early antigen, predominately to the diffuse component, were found in 22(88%). Specific IgM to EBV was detected in 17(81%) of 21 children's sera examined. The initial sera of 14(56%) children contained antibodies to viral capsid antigen but lacked antibodies to nuclear antigen of EBV. The latter was further evidence of a primary EBV infection. EBV was isolated from the oropharynx in 12(63%) of 19 children tested. Children <3 yrs of age tended to lack IM-associated heterophile antibodies and have a higher rate of antibodies to restricted component of early antigen than the older group. Two children 4 mo and 2 yrs old, probably did not have an EBV-induced disease. The type and duration of the immune response and the rate and duration of EBV isolation were roughly similar to that noted in adults with EBV-induced IM. EBV specific serologic and virologic cesting is a valuable diagnostic aid particularly when the heterophile antibody test is negative, early or throughout the course of IM, or the clinical presentation is atypical. More... »

PAGES

500

Journal

TITLE

Pediatric Research

ISSUE

S4

VOLUME

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197804001-00824

DOI

http://dx.doi.org/10.1203/00006450-197804001-00824

DIMENSIONS

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