401 TRANSPLACENTALLY INDUCED LIVER INJURY DUE TO LITHOCHOLATE: CANALICULAR Na, K-ACTIVATED ATPase AND MEMBRANE MICROVISCOSITY IN NEWBORNS View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1978-04

AUTHORS

Yoram Bujanover, Barbara Sharp, Joanne O Whitney, M Michael Thaler

ABSTRACT

Administration of lithocholate (L) to pregnant rats has been shown to induce inflammatory lesions in liver of newborn offspring, progressing to intrahepatic biliary hypoplasia and chronic cholestasis (Gastroenterology 73:1214, 1977). The site of action and mechanism of L toxicity in utero was investigated in newborn rats delivered by dams maintained on standard chow (S) or S+2.5% L throughout pregnancy. Newborns were sacrificed at 1,2, and 5 days after birth, plasma collected, and liver removed for histological examination and isolation of canaliculi-enriched plasma membranes. Membrane Na, K-activated ATPase activity was assayed, and surface microviscosity (mV) determined by fluorescence polarization. Plasma L concentration was 2-3 μmol/L in treated, and was undetectable in untreated newborns. Hepatic changes in L-treated newborns were periportal inflammation, formation of pseudoducts and giant cells. ATPase activity in membranes from L-treated newborns was reduced by 40% compared with normals (2.58±0.30 vs 4.14±0.45 μmol P/hr/mg protein). Canalicular mV (in poises) was increased by 30% in L-treated newborns compared with normals (5.65±0.30 vs 3.99±0.18; p<0.01). Conclusion: Exposure to L in utero is associated with changes in canalicular membrane function and physical properties known to interfere with bile secretion, and may thus initiate a self-perpetuating cholestatic disorder after birth. More... »

PAGES

430-430

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197804001-00406

DOI

http://dx.doi.org/10.1203/00006450-197804001-00406

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051094548


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