Histamine Receptors In The Newborn'S Pulmonary Circulation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-04

AUTHORS

B Goetzman, J Milstein, R Wennberg

ABSTRACT

Histamine causes pulmonary vasoconstriction, mediated by histamine H1-receptors, in adult animals, including sheep. In contrast, histamine is a pulmonary vasodilator in fetal sheep. However, there is little information on the transition from the fetal to adult response and the involvement of histamine H1, and H2-receptors. We have investigated pulmonary vascular histamine receptor antagonists, diphenhydramine and metiamide, respectively. Lambs were anesthetized with chloralose and instrumented for measurement of pulmonary blood flow and aortic, pulmonary arterial, and left atrial blood pressures. In 10 normoxemic animals, histamine (1μg/kg) transiently decreased mean pulmonary vascular resistance by 49 ± 28%. H2-receptor blockade with diphenhydramine did not alter this response. H2- receptor blockade with metiamide had a variable and incomplete attenuation of this response. In a 9 day old lamb, histamine (1μg/kg) increased pulmonary vascular resistance by 100% (adult type response) and after H1-blockade, decreased the resistance by 72% (newborn type response). We conclude that in the pulmonary circulation of newborn lambs, 1) histamine H3-receptor activity is absent, and 2) the action of histamine is probably due to stimulation of H2-or previously undescribed H3-receptors. The rapid transition to the adult response appears to be due to development of H1-receptor activity. More... »

PAGES

571-571

Identifiers

URI

http://scigraph.springernature.com/pub.10.1203/00006450-197704000-01209

DOI

http://dx.doi.org/10.1203/00006450-197704000-01209

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024298357


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